Getting Started With Zepbound

00:00-00:10

[Blue and green Zepbound logo appears on a white background; ambient instrumental music plays quietly]

CAPTION: Zepbound®

(tirzepatide) injection 0.5 mL or 0.6 mL

2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg

A Lilly Medicine

CAPTION: How to Use Zepbound® KwikPen® for single-patient use

00:10-00:47

[Indications and Limitations of Use for Zepbound appear on the screen placed below the logo and video title.]

CAPTION: Zepbound®

(tirzepatide) injection 0.5 mL or 0.6 mL

2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg

A Lilly Medicine

CAPTION: How to Use Zepbound® KwikPen® for single-patient use

CAPTION: Indications and Limitations of Use

Zepbound is an injectable prescription medicine that may help adults with:

• obesity, or some adults with overweight who also have weight-related medical problems to lose excess body weight and keep the weight off.

• moderate to severe obstructive sleep apnea (OSA) and obesity to improve their OSA.

It should be used with a reduced-calorie diet and increased physical activity.

Zepbound contains tirzepatide and should not be used with other tirzepatide-containing products or any GLP-1 receptor agonist medicines. It is not known if Zepbound is safe and effective for use in children.

00:47-01:29

[Indications and Limitations of Use for Zepbound is replaced with Select Safety Information.]

CAPTION: Zepbound®

(tirzepatide) injection 0.5 mL or 0.6 mL

2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg

A Lilly Medicine

CAPTION: How to Use Zepbound® KwikPen® for single-patient use

CAPTION: Select Safety information.

Warning: Tell your healthcare provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In studies with rats, Zepbound and medicines that work like Zepbound caused thyroid tumors, including thyroid cancer. It is not known if Zepbound will cause thyroid tumors, or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people. Do not take Zepbound if you or any of your family have ever had MTC or if you have an endocrine system condition called multiple endocrine neoplasia syndrome type 2 (MEN 2).

CAPTION: See Indications and Safety Summary with Warnings at the end of this video.

01:29-01:34

[Select safety information for Zepbound fades to only display the video title and the Zepbound logo lockup against a white background.]

NARRATOR: In this video, you'll learn how to use the Zepbound KwikPen for single-patient use.

CAPTION: Zepbound®

(tirzepatide) injection 0.5 mL or 0.6 mL

2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg

A Lilly Medicine

CAPTION: How to Use Zepbound® KwikPen® for single-patient use

01:34-02:07

[Green and blue text appears on screen as narrator talks; an illustration of a Zepbound KwikPen carton is on the right-hand side of the screen; the carton opens at the top and a KwikPen device shows next to the open carton.]

NARRATOR: Be sure to read the Instructions for Use before you start injecting Zepbound KwikPen and each time you get another new KwikPen. There may be new information. This information does not take the place of talking to your healthcare provider about your medical condition or your treatment. Do not share your Zepbound KwikPen with other people, even if the pen needle has been changed. You may give other people a serious infection or get a serious infection from them. People who are blind or have vision problems should not use the KwikPen without help from a person trained to use the KwikPen.

CAPTION: Getting started with your Zepbound® (tirzepatide) KwikPen® injection

Read the Instructions for Use before you start injecting Zepbound and each time you get a new KwikPen

Do not share your KwikPen with other people, even if the pen needle has been changed. You may give other people a serious infection or get a serious infection from them.

CAPTION:

once weekly

Zepbound®

(tirzepatide) injection

02:07-02:21

[An illustrated image of the KwikPen appears as a close-up on the left-hand side of the screen; to the right of the pen is a calendar with the Zepbound KwikPen dosing schedule]

NARRATOR: Each KwikPen is a disposable multi-dose pen that contains four once-weekly doses that are injected under the skin subcutaneously. Each KwikPen is for one patient only and should not be used by anyone other than you, even if the needle is changed.

CAPTION: Zepbound® KwikPen® dosing

KwikPen can be injected any day of the week; this is intended to be an example only.

CAPTION:

once weekly

Zepbound®

(tirzepatide) injection

02:21-02:45

[An illustration of the interior of a refrigerator animates on screen; on one of the shelves is a closed KwikPen carton]

NARRATOR: Before we get started, store unused KwikPens in the refrigerator between 36°F to 46°F, or 2°C to 8°C. Unused KwikPens may be used until the expiration date printed on the label if the KwikPen has been kept in the refrigerator. Do not freeze your KwikPen, and if it has been frozen, throw it away.

CAPTION: Storing your unused Zepbound® KwikPen®

Store unused KwikPen in the refrigerator between 36°F to 46°F (2°C to 8°C).

• Unused KwikPen may be used until the expiration date printed on the label if the KwikPen has been kept in the refrigerator.

• Do not freeze your KwikPen. Throw away the KwikPen if it has been frozen.

CAPTION:

once weekly

Zepbound®

(tirzepatide) injection

02:45-03:05

[A horizontal illustration of the KwikPen centers on screen then shrinks and moves to the right side of the screen, next to a sharps disposal container, gauze, an alcohol swab, and a pen needle]

NARRATOR: Ready to learn how to use the Zepbound KwikPen? Let’s begin by preparing for your once-weekly injection.

You'll need a Zepbound KwikPen, a KwikPen-compatible pen needle, an alcohol swab, gauze or a cotton ball, and an FDA-cleared sharps disposal container or household container.

CAPTION: Zepbound® KwikPen® dosing

CAPTION: Preparing for your Zepbound® KwikPen® injection

CAPTION: Gather supplies:

• 1 Zepbound KwikPen

• 1 KwikPen-compatible Pen needle (not included)

• 1 alcohol swab

• Gauze or a cotton ball

• 1 FDA-cleared sharps disposal container or household container

CAPTION:

once weekly

Zepbound®

(tirzepatide) injection

03:05-03:28

[More instructions for use appear on the screen in a bulleted list.]

NARRATOR: The KwikPen will prevent you from dialing a full 0.6 mL dose after you've given yourself four weekly doses. Attempting to inject any leftover medicine could result in an incomplete dose, even though the KwikPen still has medication left in it. Don't inject the leftover medication or transfer Zepbound from your KwikPen into a syringe.

CAPTION: Preparing for your Zepbound® KwikPen® injection

CAPTION:

• The KwikPen will prevent you from dialing a full 0.6 mL dose after you have given yourself 4 weekly doses

• Attempting to inject any leftover medicine could result in an incomplete dose even though the KwikPen still has medication left in it

• Do not inject the leftover medication

• Do not transfer Zepbound from your KwikPen into a syringe

CAPTION:

once weekly

Zepbound®

(tirzepatide) injection

03:28-03:43

[More instructions appear on the screen.]

CAPTION: Preparing for your Zepbound® KwikPen® injection

CAPTION: Always use a new pen needle for each injection to prevent infections and blocked needles. Do not share your Zepbound KwikPen with other people, even if the pen needle has been changed. You may give other people a serious infection or get a serious infection from them.

CAPTION:

once weekly

Zepbound®

(tirzepatide) injection

03:43-03:51

[The various parts of the KwikPen are illustrated and labeled on screen.]

NARRATOR: The KwikPen device consists of multiple parts. You may refer back to this image as needed to familiarize yourself with the KwikPen.

CAPTION: Zepbound® KwikPen®

CAPTION: Pen Needle Parts (Needles Not Included)

Pen Cap

Cap Clip

Red Inner Seal

Cartridge

Cartridge Holder

Pen Body

Dose Indicator

Plunger

Label

Dose Window

Dose Knob

Outer Needle Shield

Inner Needle Shield

Needle

Paper Tab

03:51-03:57

[A pair of illustrated hands move back and forth with bubbles animating the background]

NARRATOR: First, wash your hands with soap and water.

CAPTION: Preparing for your Zepbound® KwikPen® injection — Step 1

Wash your hands

CAPTION:

once weekly

Zepbound®

(tirzepatide) injection

03:57-04:18

[KwikPen animates on screen; the cap is pulled off, accompanied by an arrow noting the direction to pull the cap]

NARRATOR: Next, pull the cap straight off and inspect the KwikPen and label. Do not use the KwikPen if the medication name or dose strength doesn't match your prescription, if the KwikPen is expired or looks damaged, or if the medication has been frozen, has particles, is cloudy, or is discolored. Zepbound should be colorless to slightly yellow.

CAPTION: Preparing the Zepbound® KwikPen® — Step 2

• Pull cap straight off

• Inspect KwikPen and label

DO NOT USE IF:

• Medication name or dose strength is wrong

• KwikPen is expired or appears damaged

• Medication has been frozen, has particles, is cloudy or discolored

• Zepbound should be colorless to slightly yellow

CAPTION:

once weekly

Zepbound®

(tirzepatide) injection

04:18-04:24

[A person’s hands holding a KwikPen animate on screen; the hands wipe the red inner seal with an alcohol swab]

NARRATOR: Wipe the red inner seal with the alcohol swab.

CAPTION: Preparing the Zepbound® KwikPen®  — Step 3

• Wipe red inner seal with alcohol swab

CAPTION:

once weekly

Zepbound®

(tirzepatide) injection

04:24-04:37

[A capped pen needle animates on screen, facing up; a pair of hands grasps the capped pen needle and flips it upside down, pulling the paper tab off the outer needle shield; an accompanying arrow indicates the direction to pull the paper tab]

NARRATOR: Select a new pen needle. Always use a new pen needle for each injection to help prevent infections and blocked needles. Pull off the paper tab from the outer needle shield.

CAPTION: Preparing the Zepbound® KwikPen® — Step 4

• Select a new pen needle

• Pull off the paper tab from the outer needle shield

Always use a new pen needle for each injection to help prevent infections and blocked needles.

CAPTION:

once weekly

Zepbound®

(tirzepatide) injection

04:37-04:44

[The capped pen needle is pushed onto the KwikPen and is twisted, with an accompanying arrow indicating which direction to turn the needle]

NARRATOR: Now, push the pen needle straight onto the KwikPen and twist the pen needle on until it is tight.

CAPTION: Preparing the Zepbound® KwikPen® — Step 5

• Push the capped pen needle straight onto the KwikPen

• Twist the pen needle until it is tight

CAPTION:

once weekly

Zepbound®

(tirzepatide) injection

04:44-04:55

[The top of the pen, showing the outer needle shield, animates on screen; the outer needle shield is pulled up and off, with a green arrow showing the direction it should be pulled in order to remove; the inner needle shield is also then removed in the same manner]

NARRATOR: Pull off the outer needle shield and keep it. This will be reused. Then, pull off the inner needle shield and put it in your household trash.

CAPTION: Preparing the Zepbound® KwikPen® — Step 6

• Pull off the outer needle shield and keep it to reuse later

• Pull off inner needle shield and place in household trash

Outer Needle Shield

Inner Needle Shield

CAPTION:

once weekly

Zepbound®

(tirzepatide) injection

04:55-05:13

[A zoomed-in view of the dose window and dose knob on the Zepbound KwikPen animates on screen, with a hand holding the dosing knob; the hand turns the dosing knob until the extended line appears in the dose window; an arrow accompanies the animation to indicate which direction to turn the knob]

NARRATOR: Slowly turn the dose knob until you hear two clicks and the extended line is shown in the dose window. This is the prime position. It can be corrected by turning the dose knob in either direction until the prime position lines up to the dose indicator.

CAPTION: Priming the Zepbound® KwikPen® — Step 7

• Slowly turn the dose knob until you hear two clicks and the extended line is shown in the dose window

This is the prime position.

Extended Line

• It can be corrected by turning the dose knob in either direction until the prime position lines up to the dose indicator

Dose Indicator

CAPTION:

once weekly

Zepbound®

(tirzepatide) injection

05:13-05:21

[A pair of hands hold a Zepbound KwikPen with the needle pointing up; one finger gently taps the cartridge holder to collect air bubbles at the top; an accompanying arrow notes where the air bubbles will collect.]

NARRATOR: Hold your KwikPen with the needle pointing up and tap the cartridge holder gently to collect air bubbles at the top.

CAPTION: Priming the Zepbound® KwikPen®— Step 8

• Hold your KwikPen with the needle pointing up

• Tap the cartridge holder gently to collect air bubbles at the top

CAPTION:

once weekly

Zepbound®

(tirzepatide) injection

05:21-06:11

[A single hand holds the Zepbound KwikPen with the needle pointing up; a zoomed-in view of the needle shows a small amount of medicine dripping out of the needle; a small stopwatch animates to illustrate how long to hold the dose knob for.]

NARRATOR: Release some medicine into the air by pushing the dose knob in until it stops.

Then slowly count to five while holding the dose knob. The number zero must be shown in the dose window. Do not inject into your body.

Priming ensures that air is removed from the cartridge and makes sure that your KwikPen is working correctly. Your KwikPen has been primed if a small drop of medicine comes out of the tip of the pen needle. If you do not see medicine, repeat steps 7 through 9 no more than two additional times.

If you still do not see medicine, change the pen needle and repeat steps 7 through 9 no more than one additional time. If you still don't see medicine, contact Lily at 1-800-LillyRx.

CAPTION: Priming the Zepbound® KwikPen®— Step 9

• Release some medicine into the air by pushing the dose knob in until it stops

• Slowly count to 5 while holding the dose knob

• The number 0 must be shown in the dose window. Do not inject into your body

• Priming removes air from the cartridge and makes sure that your KwikPen is working correctly.

• Your KwikPen has been primed if a small amount (a drop) of medicine comes out of the tip of the Pen needle.

• If you do not see medicine, repeat Steps 7-9 no more than 2 additional times.

• If you still do not see medicine, then change the pen needle and repeat Steps 7-9 no more than 1 additional time

• If you still do not see medicine, contact Lilly at 1-800-LillyRx (1-800-545-5979).

CAPTION:

once weekly

Zepbound®

(tirzepatide) injection

06:11-06:35

[A diagram of a person animates on screen, purple ovals highlighting the stomach area and thighs, then the back of the upper arms]

NARRATOR: Now, choose your injection site. You or another person can inject the medicine in your thigh or stomach – at least two inches from the belly button. Or another person can give you the injection in the back of your upper arm. Change or rotate your injection site each week. You may use the same area of your body, but be sure to choose a different injection site in that area.

CAPTION: Choosing an injection site — Step 10

• You or another person can inject the medicine in your thigh or stomach (abdomen), at least 2 inches from the belly button

• Another person should give you the injection in the back of your upper arm

• Change (rotate) your injection site each week

CAPTION:

once weekly

Zepbound®

(tirzepatide) injection

06:35-06:47

[A hand grips the dose knob on the Zepbound KwikPen. An accompanying arrow

indicates the direction to turn the knob, and the dose indicator is pulled out.]

NARRATOR: Turn the dose knob until it stops and the dose window displays the number one. This position is equivalent to a full dose. Do not count clicks as you select the dose.

CAPTION: Injecting the medicine — Step 11

Turn the dose knob until it stops AND the number 1 is in the dose window. This is equivalent to a full 0.6 mL dose.

Do not count clicks as you select the dose.

CAPTION:

once weekly

Zepbound®

(tirzepatide) injection

06:47-07:07

[A person’s hand holds the Zepbound KwikPen while the other hand lifts up their shirt to expose their belly, preparing for the injection. An accompanying arrow indicates where to move with the KwikPen. The thumb holding the KwikPen pushes the dose knob down, injecting Zepbound, while a small stopwatch animates on screen to illustrate how long to hold the dose knob down for.]

NARRATOR: Now, insert the needle into your skin. Inject the medicine by pushing the dose knob in until it stops. Then, slowly count to five while holding the dose knob. The number zero must be shown in the dose window before removing the needle.

CAPTION: Injecting the medicine — Step 12

• Insert the needle into your skin

• Inject the medicine by pushing the dose knob in until it stops

PUSH

• Slowly count to 5 while holding the dose knob

• The number 0 must be shown in the dose window before removing the needle

Hold for 5 sec

07:07-07:44

[A person’s hand holds the Zepbound KwikPen while the other hand lifts up the shirt to expose the belly; the KwikPen is pulled out and removed from the skin. An accompanying arrow indicates the direction the KwikPen is being pulled.]

NARRATOR: Finally, pull the needle out of your skin. A drop of medicine on the needle tip is normal and won't affect your dose.

Confirm the number zero is in the dose window. If you see the number zero in the dose window, you have received the full dose. If you don't see the number zero in the dose window, insert the needle back into your skin and finish your injection. Do not redial the dose. If you still don't think you received the full dose, do not start over or repeat the injection. Contact Lilly at 1-800-LillyRx.

CAPTION: Injecting the medicine — Step 13

• Pull the needle out of your skin

• A drop of medicine on the needle tip is normal. It will not affect your dose

• Confirm the number 0 is in the dose window

• If you see the number 0 in the dose window, you have received the full dose

• If you do not see the number 0 in the dose window, insert the needle back into your skin and finish your injection

• Do not redial the dose

If you still do not think you received the full dose, do not start over or repeat the injection. Contact Lilly at 1-800-LillyRx (1-800-545-5979).

07:44-07:48

[A person’s hand holds the KwikPen with the exposed needle; the outer needle shield is placed back onto the pen; a green arrow indicates the direction to twist.]

NARRATOR: Carefully replace the outer needle shield.

CAPTION: After Zepbound® KwikPen® injection — Step 14

Carefully replace the outer needle shield.

CAPTION:

once weekly

Zepbound®

(tirzepatide) injection

07:48-08:07

[A person’s hand holds the new needle shield capped on the Kwikpen and twists it off; a green arrow indicates the direction to rotate; a sharps container opens and a used needle is tossed into it; a person’s hand unscrews the capped needle; an accompanying arrow indicates the direction to twist.]

NARRATOR: Then, unscrew the capped needle and put it in a sharps container. Put your used pen needle in an FDA-cleared sharps disposal container right away after use. Do not store the KwikPen with the needle attached to prevent leaking, blocking the needle, and air from entering the KwikPen.

CAPTION: After Zepbound® KwikPen® injection—Step 15

Unscrew the capped needle and put the needle in a sharps container

Disposing of your used pen needle

• Do not throw away loose pen needles in your household trash

Do not store the KwikPen with the needle attached to prevent:

• Leaking

• Blocking the needle

• Air from entering the KwikPen

CAPTION:

once weekly

Zepbound®

(tirzepatide) injection

08:07-08:15

[A person’s hand holds a cotton ball against the injection site on the belly while the other hand holds their shirt up.]

NARRATOR: If you see blood after you remove the needle, lightly press the injection site with gauze or a cotton ball. Do not rub the injection site.

CAPTION: After Zepbound® KwikPen® injection — Step 16

• If you see blood after you pull the needle out of your skin, lightly press the injection site with gauze or a cotton ball

• Do not rub the injection site

08:15-08:20

[An image of the Zepbound KwikPen with the KwikPen cap being replaced; an accompanying arrow indicates the direction the KwikPen cap is moving]

NARRATOR: Replace the KwikPen cap. Do not store the KwikPen without the KwikPen cap attached.

CAPTION: After Zepbound® KwikPen® injection — Step 17

• Replace the KwikPen cap

• Do not store the KwikPen without the KwikPen cap attached

CAPTION:

once weekly

Zepbound®

(tirzepatide) injection

08:20-08:55

[An open trash can is illustrated on screen.]

NARRATOR: Throw away the KwikPen after receiving four weekly doses. Discard the used KwikPen in your household trash or FDA-cleared sharps disposal container after you have removed the needle. Do not throw away loose pen needles in your household trash. The KwikPen will prevent you from dialing a full 0.6 mL dose after you've given yourself four weekly doses. Attempting to inject any leftover medicine could result in an incomplete dose even though the KwikPen still has medication left in it. Don't inject the leftover medication or transfer Zepbound from your KwikPen into a syringe.

CAPTION: Disposing of your used Zepbound® KwikPen®

• Throw away the KwikPen after receiving 4 weekly doses

• Discard the used KwikPen in your household trash or FDA-cleared sharps disposal container after you have removed the needle

• Do not throw away loose pen needles in your household trash

• The KwikPen will prevent you from dialing a full 0.6 mL dose after you have given yourself 4 weekly doses.

• Attempting to inject any leftover medicine could result in an incomplete dose even though the KwikPen still has medication left in it.

• Do not inject the leftover medication

• Do not transfer Zepbound from your KwikPen into a syringe

CAPTION:

once weekly

Zepbound®

(tirzepatide) injection

08:55-09:30

[An image of a sharps container]

NARRATOR: If you don't have an FDA-cleared sharps disposal container, you may use a household container that is made of a heavy-duty plastic, can be closed with a tight-fitting, puncture-resistant lid without sharps being able to come out, is upright and stable during use, is leak-resistant, and is properly labeled to warn of hazardous waste inside the container. Do not recycle your used sharps disposal container. When your sharps disposal container is almost full, you will need to follow your community guidelines for the right way to dispose of your sharps disposal container. There may be state or local laws about how you should throw away use needles.

CAPTION: Disposing of your used pen needle

• If you do not have a puncture-resistant, FDA-cleared sharps container, you may use a household container that is:

• Made of a heavy-duty plastic

• Can be closed with a tight-fitting, puncture-resistant lid without sharps being able to come out

• Upright and stable during use

• Leak-resistant

• Properly labeled to warn of hazardous waste inside the container

Do not dispose of your used sharps disposal container in your household trash unless your community guidelines permit this. Do not recycle your used sharps disposal container.

CAPTION:

once weekly

Zepbound®

(tirzepatide) injection

09:30-09:50

[An image of a sharps container]

NARRATOR: For more information about safe sharps disposal, and for specific information about sharps disposal in the state you live in, go to the FDA's website at www.fda.gov/safesharpsdisposal, ask your healthcare provider, or follow the community guidelines in your area on how to properly dispose of your sharps disposal container.

CAPTION: Disposing of your used pen needle

CAPTION: For more information about safe sharps disposal, and for specific information about sharps disposal in the state you live in, go to the FDA's website at: https://www.fda.gov/safesharpsdisposal.

09:50-10:05

[An image of a Zepbound KwikPen inside a nightstand drawer]

NARRATOR: You may store your used KwikPen at room temperature up to 86°F or 30°C after your injection. Keep your KwikPen away from heat and light, and keep your KwikPen and pen needles out of the sight and reach of children.

CAPTION: Storing your used Zepbound® KwikPen®

You may store your used KwikPen at room temperature up to 86°F (30°C) after your injection

• Keep away from heat and light

• Keep your KwikPen and pen needles out of the sight and reach of children

CAPTION:

once weekly

Zepbound®

(tirzepatide) injection

10:05-10:29

[A used Zepbound KwikPen being thrown in the trash can; resources to seek additional information on Zebound appears on the screen, followed by the trademark information.]

NARRATOR: Throw away your KwikPen 30 days after first use even though the KwikPen has medication left in it. The KwikPen should not be used past its 30-day in-use period. If you have any questions or concerns about administering Zepbound, please contact your healthcare provider or Lilly at 1-800-LillyRx.

CAPTION: Disposing of your used Zepbound® KwikPen®

Throw away the KwikPen 30 days after first use even though the KwikPen has medication left in it

If you have any questions about injecting Zepbound® (tirzepatide) or problems with your Zepbound KwikPen®, contact your healthcare provider or Lilly at 1-800-LillyRx (1-800-545-5979).

For more information about Zepbound, visit our website at Zepbound.Lilly.com

Zepbound®, its delivery device base, and KwikPen® are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.

Zepbound is available by prescription only.

CMAT-19458 03/2026

©Lilly USA, LLC 2026. All rights reserved.

CAPTION:

once weekly

Zepbound®

(tirzepatide) injection

10:29-18:34

[Indications and Safety Summary with Warnings for Zepbound appears on screen. After a short pause, it starts scrolling automatically.]

CAPTION: once weekly

Zepbound®

(tirzepatide) injection

CAPTION: INDICATIONS AND SAFETY SUMMARY WITH WARNINGS

Zepbound® (ZEHP-bownd) is an injectable prescription medicine used with a reduced-calorie diet and increased physical activity to help adults with:

• obesity, or some adults with overweight who also have weight-related medical problems, to lose excess body weight and keep the weight off.

• moderate-to-severe obstructive sleep apnea (OSA) and obesity to improve their OSA.

Zepbound contains tirzepatide and should not be used with other tirzepatide-containing products or any GLP-1 receptor agonist medicines. It is not known if Zepbound is safe and effective for use in children.

Warnings - Zepbound may cause tumors in the thyroid, including thyroid cancer. Watch for possible symptoms, such as a lump or swelling in the neck, hoarseness, trouble swallowing, or shortness of breath. If you have any of these symptoms, tell your healthcare provider.

• Do not use Zepbound if you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC).

• Do not use Zepbound if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).

• Do not use Zepbound if you have had a serious allergic reaction to tirzepatide or any of the ingredients in Zepbound.

KwikPen®: Do not share your KwikPen with other people, even if the pen needle has been changed.  You may give other people a serious infection or get a serious infection from them.

Zepbound may cause serious side effects, including:

Severe stomach problems. Stomach problems, sometimes severe, have been reported in people who use Zepbound. Tell your healthcare provider if you have stomach problems that are severe or will not go away.

Dehydration leading to kidney problems. Diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration), which may cause kidney problems. It is important for you to drink fluids to help reduce your chance of dehydration. Tell your healthcare provider right away if you have nausea, vomiting, or diarrhea that does not go away.

Gallbladder problems. Gallbladder problems have happened in some people who use Zepbound. Tell your healthcare provider right away if you get symptoms of gallbladder problems, which may include pain in your upper stomach (abdomen), fever, yellowing of skin or eyes (jaundice), or clay-colored stools.

Inflammation of the pancreas (pancreatitis). Stop using Zepbound and call your healthcare provider right away if you have severe pain in your stomach area (abdomen) that will not go away, with or without nausea or vomiting. You may feel the pain from your abdomen to your back.

Serious allergic reactions. Stop using Zepbound and get medical help right away if you have any symptoms of a serious allergic reaction, including swelling of your face, lips, tongue or throat, problems breathing or swallowing, severe rash or itching, fainting or feeling dizzy, or very rapid heartbeat.

Low blood sugar (hypoglycemia). Your risk for getting low blood sugar may be higher if you use Zepbound with medicines that can cause low blood sugar, such as a sulfonylurea or insulin. Signs and symptoms of low blood sugar may include dizziness or light-headedness, sweating, confusion or drowsiness, headache, blurred vision, slurred speech, shakiness, fast heartbeat, anxiety, irritability, mood changes, hunger, weakness or feeling jittery.

Changes in vision in patients with type 2 diabetes. Tell your healthcare provider if you have changes in vision during treatment with Zepbound.

Food or liquid getting into the lungs during surgery or other procedures that use anesthesia or deep sleepiness (deep sedation). Zepbound may increase the chance of food getting into your lungs during surgery or other procedures. Tell all your healthcare providers that you are taking Zepbound before you are scheduled to have surgery or other procedures.

Common side effects

The most common side effects of Zepbound include nausea, diarrhea, vomiting, constipation, stomach

(abdominal) pain, indigestion, injection site reactions, feeling tired, allergic reactions, belching, hair loss ,

and heartburn. These are not all the possible side effects of Zepbound. Talk to your healthcare provider about any side effect that bothers you or doesn’t go away.

Tell your doctor if you have any side effects. You can report side effects at 1-800-FDA-1088 or www.fda.gov/medwatch.

Before using Zepbound

• Your healthcare provider should show you how to use Zepbound before you use it for the first time.

• Talk to your healthcare provider about low blood sugar and how to manage it. Tell your healthcare provider if you are taking medicines to treat diabetes including an insulin or sulfonylurea.

• If you take birth control pills by mouth, talk to your healthcare provider before you use Zepbound. Birth control pills may not work as well while using Zepbound. Your healthcare provider may recommend another type of birth control for 4 weeks after you start Zepbound and for 4 weeks after each increase in your dose of Zepbound.

Review these questions with your healthcare provider:

❑ Do you have other medical conditions, including problems with your pancreas, or severe problems with your stomach, such as slowed emptying of your stomach (gastroparesis) or problems digesting food?

❑ Do you take diabetes medicines, such as insulin or sulfonylureas?

❑ Do you have a history of diabetic retinopathy?

❑ Are you scheduled to have surgery or other procedures that use anesthesia or deep sleepiness (deep sedation)?

❑ Do you take any other prescription medicines or over-the-counter drugs, vitamins, or herbal supplements?

❑ Are you pregnant, plan to become pregnant, breastfeeding, or plan to breastfeed? Zepbound may harm your unborn baby. Tell your healthcare provider if you become pregnant while using Zepbound. Zepbound may pass into your breast milk. You should talk with your healthcare provider about the best way to feed your baby while using Zepbound.

• Pregnancy Exposure Registry: There will be a pregnancy exposure registry for women who have taken Zepbound during pregnancy. The purpose of this registry is to collect information about the health of you and your baby. Talk to your healthcare provider about how you can take part in this registry, or you may contact Lilly at 1-800-LillyRx (1-800-545-5979).

How to take

• Read the Instructions for Use that come with Zepbound.

• Use Zepbound exactly as your healthcare provider says.

• Use Zepbound with a reduced-calorie diet and increased physical activity.

• Inject Zepbound under the skin (subcutaneously) of your stomach (abdomen), thigh, or
  have another person inject in the back of the upper arm. Do not inject ZEPBOUND into a muscle (intramuscularly) or vein (intravenously).
• Use Zepbound 1 time each week, at any time of the day.

• Change (rotate) your injection site with each weekly injection. Do not use the same site for each injection.

If you take too much Zepbound, call your healthcare provider, call the Poison Help line at 1-800-222-1222 or go to the nearest hospital emergency room right away.

Zepbound is approved as a 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, and 15 mg injection.

Learn more

Zepbound is a prescription medicine. For more information, call 1-800-LillyRx (1-800-545-5979) or go to www.zepbound.lilly.com.

This summary provides basic information about Zepbound but does not include all information known about this medicine. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your healthcare provider. Be sure to talk to your healthcare provider about Zepbound and how to take it. Your healthcare provider is the best person to help you decide if Zepbound is right for you.

ZP CON BS 25FEB2026

Lilly

18:34-18:46

[The scrolling text ends. Zepbound logo and trademark information appear on a white background.]

CAPTION: once weekly

Zepbound®

(tirzepatide) injection

A Lilly Medicine

Visit zepbound.lilly.com

© Lilly USA, LLC 2026. All rights reserved.

Zepbound®, its delivery device base, and KwikPen® are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.

Voice over generated by Al.

18:46-18:53

[Screen fades to a red background with the Lilly logo in the center.]

CAPTION: Lilly

A MEDICINE COMPANY

video-item, video-standard, titleplacement-top, descriptionplacement-center, ctacolor-light, ctastyle-primary, buttonctastyle-arrow, overlayeffect-light

00:00-00:47

[The Zepbound logo and title animate on screen, followed by the Indications and Limitations of Use.]

CAPTION:

HOW TO USE

Zepbound®

(tirzepatide) injection 0.5 mL or 0.6 mL

2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg
A Lilly Medicine

Indications and Limitations of Use

Zepbound is an injectable prescription medicine that may help adults with:

• obesity, or some adults with overweight who also have weight-related medical problems to lose excess body weight and keep the weight off.

• moderate-to-severe obstructive sleep apnea (OSA) and obesity to improve their OSA.

It should be used with a reduced-calorie diet and increased physical activity.

Zepbound contains tirzepatide and should not be used with other tirzepatide-containing products or any GLP-1 receptor agonist medicines.

It is not known if Zepbound is safe and effective for use in children.

00:47-01:24

[Select Safety Information animates on screen.]

CAPTION:

HOW TO USE

Zepbound®

(tirzepatide) injection 0.5 mL or 0.6 mL

2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg
A Lilly Medicine

Select Safety Information

Warnings:

Tell your healthcare provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In studies with rats, Zepbound and medicines that work like Zepbound caused thyroid tumors, including thyroid cancer. It is not known if Zepbound will cause thyroid tumors, or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people. Do not take Zepbound if you or any of your family have ever had MTC or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).

01:24-01:29

CAPTION: HOW TO USE

Zepbound®

(tirzepatide) injection 0.5 mL or 0.6 mL

2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg
A Lilly Medicine

See Indications and Safety Summary with Warnings at the end of this video.

01:29-01:39

[Title card fades to a woman named Andrea taking a selfie video with her phone as she walks into her living room. Upbeat music plays in the background. Andrea shows us the Zepbound box and sits comfortably on her couch.]

CAPTION: Actor portrayal throughout.

ANDREA: I just got back from the pharmacy, and I bet you’re wondering what’s inside. Let’s open it together.

01:39-02:07

[The selfie screen expands to a full, wide screen as Andrea opens the Zepbound box. The box glows green, lighting up Andrea’s delighted face as she takes the Zepbound pen out of the box.]

CAPTION: 2.5 mg is a starting dose and is not an approved maintenance dose. After 4 weeks, dose should be increased to 5 mg once weekly.

CAPTION: Zepbound should be used along with a reduced-calorie meal plan and increased physical activity. Individual results may vary.

ANDREA: This is the once-weekly, single-use Zepbound pen! You may already know that Zepbound is proven to help adults with obesity lose weight along with diet and exercise. So now let's take a look at how to use the pen. And if you're like me, you may be nervous to inject for the first time. But don't worry, I'm here to walk you through each step of using it.

02:07-02:14

[Andrea holds up the Zepbound pen and looks at a graphic that animates on screen.]

CAPTION: If Zepbound is stored at room temperature, it should not be returned to the

refrigerator.

Keep it in the refrigerator between 36ºF and 46ºF, not exposed to freezing temperatures

ANDREA: To start, let's talk about how to store Zepbound. It is best to keep it in the refrigerator.

02:14-02:22

[New text animates on the graphic.]

CAPTION: Keep it in its original carton and away from direct light and heat (safe up to 86ºF)

If Zepbound is stored at room temperature, it should not be returned to the

refrigerator. Discard if not used within 21 days after removing from the refrigerator.

ANDREA: But if you're traveling and don't have access to a fridge, the pens can stay at room temperature for up to 21 days. Now, come take a closer look.

02:22-02:31

[In a close-up of the Zepbound pen in Andrea’s hand, a green graphic line traces and highlights the pen’s cap, then the 2.5 mg label.]

ANDREA: This gray cap stays on until you are ready to inject. Double-check that the pen is not damaged and that you’re taking the correct medicine and dose.

02:31-02:39

[The close-up of the Zepbound pen in Andrea's hand remains on screen as a graphic animates on.]

CAPTION:
X Frozen

X Cloudy

X Discolored

X Particles

X Expired

ANDREA: Don’t use it if the medicine is frozen, cloudy, discolored, or has any particles. And be sure to check the expiration date.

02:39-03:00

[Back to a medium shot of Andrea holding the Zepbound pen on her couch as a new graphic highlighting parts of the body animates on screen.]

CAPTION: 1. CHOOSE YOUR INJECTION SITE

ANDREA: The first step is to decide where to inject. You can do it in your stomach or thighs by yourself, or in the back of your upper arms with someone’s help. You can use the same area every week, just don’t inject into the same exact spot. Your doctor can help you with these choices. I'm going for the stomach.

03:00-03:07

[A hand-washing icon graphic animates on screen.]

ANDREA: Oh, and make sure to wash your hands before every injection. Just three more steps left.

03:07-03:18

[Andrea stands up from the couch and walks to another part of her living room. She watches as a new graphic showing a hand pulling the cap from the Zepbound pen animates on. The screen then changes to another close-up of Andrea holding the Zepbound pen.]

CAPTION: 2. PULL OFF THE CAP

ANDREA: With the pen locked, remove the gray cap and throw it away. And do not touch the base.

03:18-03:26

[Andrea places the pen on her stomach and unlocks it as another graphic showing a person placing the Zepbound pen on their stomach animates on.]

CAPTION: 3. PLACE AND UNLOCK

ANDREA: Place the clear base of the pen flat against your skin and unlock it by turning the lock ring.

03:26-03:40

[The camera moves down and zooms in on Andrea’s stomach as she gives herself the injection. Another graphic showing a person pushing the button of the Zepbound pen animates on. The pen clicks. After 10 seconds, it clicks again. Andrea finishes the injection and holds the pen to the camera while a green graphic line traces and highlights the gray plunger.]

CAPTION: 4. PRESS AND HOLD UP TO 10 SECONDS

ANDREA: Press and hold the purple button for up to 10 seconds. The first click means the injection has started. Keep holding. The second click means it’s done. The injection is complete when the gray plunger is visible.

03:40-03:56

[Andrea holds the pen up. She then disposes of the pen in an FDA-cleared sharps container before she picks up her phone.]

ANDREA: And that's all! The process is the same regardless of the dose you've been prescribed. Now you just need to safely dispose of your used pen in an FDA-cleared sharps container.

03:56-04:24

[Still filming selfie style, Andrea sets her phone down on a cabinet in her laundry room. She steps back and picks up a laundry detergent bottle, gesturing toward different areas of the bottle as she speaks.]

ANDREA: If you don't have an FDA-cleared sharps container, you can use a heavy-duty plastic household container, such as a laundry detergent bottle. And no, this isn't a paid partnership with a detergent brand. Just make sure it’s made of heavy-duty plastic, has a tight-fitting, puncture-resistant lid, is leak-resistant, and is properly labeled.

04:24-04:49

[Suddenly, Andrea’s excited and clumsy dog joins her in the laundry room, bumping into the cabinet and causing the phone to fall to the floor. Andrea picks the phone up from the floor, smiles, and pets her dog as she speaks to the phone.]

ANDREA: Just make sure you leave it in a safe place away from kids and pets! I hope I’ve helped you feel comfortable with your Zepbound injection. But if you have more questions, talk to your doctor or visit Zepbound.com.

04:49-04:55

[The green Zepbound arrows fly in, wiping on a white title card as the Zepbound logo fades on.]

CAPTION: Zepbound®

(tirzepatide) injection 0.5 mL or 0.6 mL

2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg
A Lilly Medicine

04:55-13:17

[The Zepbound logo fades out before Important Safety Information fades in and begins to scroll. Background music plays quietly.]

CAPTION:

Zepbound®

(tirzepatide) injection 0.5 mL or 0.6 mL

2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg
A Lilly Medicine

CAPTION: INDICATIONS AND SAFETY SUMMARY WITH WARNINGS

Zepbound® (ZEHP-bownd) is an injectable prescription medicine used with a reduced-calorie diet and increased physical activity to help adults with:

• obesity, or some adults with overweight who also have weight-related medical problems, to lose excess body weight and keep the weight off.

• moderate-to-severe obstructive sleep apnea (OSA) and obesity to improve their OSA.

Zepbound contains tirzepatide and should not be used with other tirzepatide-containing products or any GLP-1 receptor agonist medicines. It is not known if Zepbound is safe and effective for use in children.

Warnings - Zepbound may cause tumors in the thyroid, including thyroid cancer. Watch for possible symptoms, such as a lump or swelling in the neck, hoarseness, trouble swallowing, or shortness of breath. If you have any of these symptoms, tell your healthcare provider.

• Do not use Zepbound if you or any of your family have ever had a type of thyroid cancer called

medullary thyroid carcinoma (MTC).

• Do not use Zepbound if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).

• Do not use Zepbound if you have had a serious allergic reaction to tirzepatide or any of the

ingredients in Zepbound.

KwikPen®: Do not share your KwikPen with other people, even if the pen needle has been changed.  You may give other people a serious infection or get a serious infection from them.

Zepbound may cause serious side effects, including:

Severe stomach problems. Stomach problems, sometimes severe, have been reported in people who use Zepbound. Tell your healthcare provider if you have stomach problems that are severe or will not go away.

Dehydration leading to kidney problems. Diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration), which may cause kidney problems. It is important for you to drink fluids to help reduce your chance of dehydration. Tell your healthcare provider right away if you have nausea, vomiting, or diarrhea that does not go away.

Gallbladder problems. Gallbladder problems have happened in some people who use Zepbound. Tell your healthcare provider right away if you get symptoms of gallbladder problems, which may include pain in your upper stomach (abdomen), fever, yellowing of skin or eyes (jaundice), or clay-colored stools.

Inflammation of the pancreas (pancreatitis). Stop using Zepbound and call your healthcare provider right away if you have severe pain in your stomach area (abdomen) that will not go away, with or without nausea or vomiting. You may feel the pain from your abdomen to your back.

Serious allergic reactions. Stop using Zepbound and get medical help right away if you have any symptoms of a serious allergic reaction, including swelling of your face, lips, tongue or throat, problems breathing or swallowing, severe rash or itching, fainting or feeling dizzy, or very rapid heartbeat.

Low blood sugar (hypoglycemia). Your risk for getting low blood sugar may be higher if you use Zepbound with medicines that can cause low blood sugar, such as a sulfonylurea or insulin. Signs and symptoms of low blood sugar may include dizziness or light-headedness, sweating, confusion or drowsiness, headache, blurred vision, slurred speech, shakiness, fast heartbeat, anxiety, irritability, mood changes, hunger, weakness or feeling jittery.

Changes in vision in patients with type 2 diabetes. Tell your healthcare provider if you have changes in vision during treatment with Zepbound.

Food or liquid getting into the lungs during surgery or other procedures that use anesthesia or deep

sleepiness (deep sedation). Zepbound may increase the chance of food getting into your lungs during surgery or other procedures. Tell all your healthcare providers that you are taking Zepbound before you are scheduled to have surgery or other procedures.

Common side effects

The most common side effects of Zepbound include nausea, diarrhea, vomiting, constipation, stomach

(abdominal) pain, indigestion, injection site reactions, feeling tired, allergic reactions, belching, hair loss ,

and heartburn. These are not all the possible side effects of Zepbound. Talk to your healthcare provider about any side effect that bothers you or doesn’t go away.

Tell your doctor if you have any side effects. You can report side effects at 1-800-FDA-1088 or www.fda.gov/medwatch.

Before using Zepbound

• Your healthcare provider should show you how to use Zepbound before you use it for the first time.

• Talk to your healthcare provider about low blood sugar and how to manage it. Tell your

healthcare provider if you are taking medicines to treat diabetes including an insulin or

sulfonylurea.

• If you take birth control pills by mouth, talk to your healthcare provider before you use

Zepbound. Birth control pills may not work as well while using Zepbound. Your healthcare

provider may recommend another type of birth control for 4 weeks after you start Zepbound

and for 4 weeks after each increase in your dose of Zepbound.

Review these questions with your healthcare provider:

❑ Do you have other medical conditions, including problems with your pancreas, or

severe problems with your stomach, such as slowed emptying of your stomach (gastroparesis) or

problems digesting food?

❑ Do you take diabetes medicines, such as insulin or sulfonylureas?

❑ Do you have a history of diabetic retinopathy?

❑ Are you scheduled to have surgery or other procedures that use anesthesia or deep sleepiness (deep

sedation)?

❑ Do you take any other prescription medicines or over-the-counter drugs, vitamins, or herbal

supplements?

❑ Are you pregnant, plan to become pregnant, breastfeeding, or plan to breastfeed? Zepbound

may harm your unborn baby. Tell your healthcare provider if you become pregnant while using

Zepbound. Zepbound may pass into your breast milk. You should talk with your

healthcare provider about the best way to feed your baby while using Zepbound.

• Pregnancy Exposure Registry: There will be a pregnancy exposure registry for women who have taken Zepbound during pregnancy. The purpose of this registry is to collect information about the health of you and your baby. Talk to your healthcare provider about how you can take part in this registry, or you may contact Lilly at 1-800-LillyRx (1-800-545-5979).

How to take

• Read the Instructions for Use that come with Zepbound.

• Use Zepbound exactly as your healthcare provider says.

• Use Zepbound with a reduced-calorie diet and increased physical activity.

• Inject Zepbound under the skin (subcutaneously) of your stomach (abdomen), thigh, or
  have another person inject in the back of the upper arm. Do not inject ZEPBOUND into a muscle (intramuscularly) or vein (intravenously).
• Use Zepbound 1 time each week, at any time of the day.

• Change (rotate) your injection site with each weekly injection. Do not use the same site for each injection.

If you take too much Zepbound, call your healthcare provider, call the Poison Help line at 1-800-222-1222 or go to the nearest hospital emergency room right away.

Zepbound is approved as a 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, and 15 mg injection.

Learn more

Zepbound is a prescription medicine. For more information, call 1-800-LillyRx (1-800-545-5979) or go

to www.zepbound.lilly.com.

This summary provides basic information about Zepbound but does not include all information known about this medicine. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your healthcare provider. Be sure to talk to your healthcare provider about Zepbound and how to take it. Your healthcare provider is the best person to help you decide if Zepbound is right for you.

ZP CON BS 25FEB2026

Zepbound® , its delivery device base, and KwikPen®  are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.

Voice over generated by AI.

CMAT-19268 04/2026 © Lilly USA, LLC 2026.

All rights reserved.

Lilly

A Medicine Company

13:17-13:20

[Zepbound end card appears on screen, including the Zepbound logo, dosing information, and trademark information.]

CAPTION:

Zepbound®

(tirzepatide) injection 0.5 mL or 0.6 mL

2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg

A Lilly Medicine

Visit Zepbound.com

or call 1-800-LillyRx (1-800-545-5979) for pricing information

13:20-13:22

[Animated Lilly A Medicine Company logo appears in white text on a red background.]

CAPTION: Lilly

A MEDICINE COMPANY

©Lilly USA, LLC 2026. All rights reserved.

Zepbound^®, its delivery device base and KwikPen^® are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.

video-item, video-standard, title-fs-60px, ctacolor-dark, ctastyle-primary, buttonctastyle-play, transcript-fs-16px, overlayeffect-light

00:00-00:46

[The Zepbound logo animates on screen, followed by the Indications and Limitations of Use. Upbeat music plays.]

CAPTION: HOW TO USE VIAL

Zepbound®

(tirzepatide) injection 0.5 mL or 0.6 mL

2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, 15 mg
A Lilly Medicine

Indications and Limitations of Use

Zepbound is an injectable prescription medicine that may help adults with:

• obesity, or some adults with overweight who also have weight-related medical problems to lose excess body weight and keep the weight off.

• moderate to severe obstructive sleep apnea (OSA) and obesity to improve their OSA.

It should be used with a reduced-calorie diet and increased physical activity.

Zepbound contains tirzepatide and should not be used with other tirzepatide-containing products or any GLP-1 receptor agonist medicines. It is not known if Zepbound is safe and effective for use in children.

00:46-01:23

[Select Safety Information animates on screen.]

CAPTION: HOW TO USE VIAL

Zepbound®

(tirzepatide) injection 0.5 mL or 0.6 mL

2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, 15 mg
A Lilly Medicine

NARRATOR: Select Safety Information.

Warning: Tell your healthcare provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In studies with rats, Zepbound and medicines that work like Zepbound caused thyroid tumors, including thyroid cancer. It is not known if Zepbound will cause thyroid tumors, or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people. Do not take Zepbound if you or any of your family have ever had MTC or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).

01:23-01:28

CAPTION: HOW TO USE VIAL

Zepbound®

(tirzepatide) injection 0.5 mL or 0.6 mL

2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, 15 mg
A Lilly Medicine

NARRATOR: See Indications and Safety Summary with Warnings at the end of this video.

01:28-01:34

CAPTION: HOW TO USE VIAL

Zepbound®

(tirzepatide) injection 0.5 mL or 0.6 mL

2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, 15 mg
A Lilly Medicine

NARRATOR: In this video you will learn how to inject Zepbound using the single-dose vial and a needle and a syringe.

01:34-01:50

[An illustration of a refrigerator animates on screen. The Zepbound logo appears and remains on screen in the lower right-hand corner.]

CAPTION: Once weekly

Zepbound®

(tirzepatide) injection

A Lilly Medicine

Getting started with your Zepbound® (tirzepatide) injection

Read the Instructions for Use before you start taking Zepbound and each time you get a new vial.

Do not share your needles or syringes with other people. You may give other people a serious infection or get a serious infection from them.

NARRATOR: Be sure to read the Instructions for Use before you start taking Zepbound and each time you get a new vial. There may be new information. This information does not take the place of talking to your healthcare provider about your medical condition or your treatment.

01:50-01:59

[A carton of Zepbound animates on screen.]

CAPTION: Once weekly

Zepbound®

(tirzepatide) injection

A Lilly Medicine

Getting started with your Zepbound® (tirzepatide) injection

Read the Instructions for Use before you start taking Zepbound and each time you get a new vial.

Do not share your needles or syringes with other people. You may give other people a serious infection or get a serious infection from them.

NARRATOR: Do not share your needles or syringes with other people. You may give other people a serious infection or get a serious infection from them.

01:59-02:15

[A carton of Zepbound and vial animate on screen.]

CAPTION: Once weekly

Zepbound®

(tirzepatide) injection

A Lilly Medicine

Getting started with your Zepbound® (tirzepatide) injection

Read the Instructions for Use before you start taking Zepbound and each time you get a new vial.

Do not share your needles or syringes with other people. You may give other people a serious infection or get a serious infection from them.

NARRATOR: The Zepbound single-dose vial is a subcutaneous injection, which means it is injected under the skin. Ready to learn how to use the Zepbound single-dose vial? Let’s begin with preparing for your once-weekly injection.

02:15-02:21

[An illustration of the inside of an open refrigerator door animates on screen, highlighting a carton of Zepbound on one of the shelves. The refrigerator illustration fades away as the animation zooms in on a Zepbound vial.]

CAPTION: Once weekly

Zepbound®

(tirzepatide) injection

A Lilly Medicine

Preparing for your Zepbound® injection

• Remove the vial from the refrigerator

NARRATOR: Remove the vial from the refrigerator. Remove the single-dose vial from the carton.

02:21-02:29

[Instructions appear in a bulleted list on screen to the left of the vial]

CAPTION: Once weekly

Zepbound®

(tirzepatide) injection

A Lilly Medicine

The Zepbound® vial

• Check the medicine and dose

• Check that it has not expired

NARRATOR: Check the single-dose vial label to make sure you have the right medicine and dose and that it has not expired.

02:29-02:39

[A blue line highlights the medicine at the bottom of the Zepbound vial.]

CAPTION: Once weekly

Zepbound®

(tirzepatide) injection

A Lilly Medicine

The Zepbound® vial

• The medicine is colorless to slightly yellow

• Make sure the medicine is not frozen, not cloudy, and does not have particles in it

NARRATOR: Make sure the medicine is colorless to slightly yellow. Make sure the medicine is not frozen, not cloudy, and does not have particles in it.

02:39-02:57

[In addition to the Zepbound vial, a syringe and needle, an alcohol swab, gauze, and a sharps container animate on screen.]

CAPTION: Once weekly

Zepbound®

(tirzepatide) injection

A Lilly Medicine

Preparing for your Zepbound® injection

Gather supplies:

• 1 single-dose Zepbound vial

• 1 syringe and 1 needle, supplied separately

• 1 alcohol swab

• Gauze

• 1 sharps container for throwing away used needles and syringes

The needle and syringe are not included. The needle and syringe recommended by your healthcare

provider may look different than the needle and syringe in this Instructions for Use video.

NARRATOR: Gather supplies needed to give your injection. You will need: one single-dose Zepbound vial, one syringe and one needle (supplied separately), one alcohol swab, gauze, and one sharps container for throwing away used needles and syringes.

02:57-03:14

[Text animates on screen.]

CAPTION: Once weekly

Zepbound®

(tirzepatide) injection

A Lilly Medicine

Preparing for your Zepbound® injection

Always use a new syringe and needle for each injection to prevent infections and blocked needles. Do not reuse or share your syringes or needles with other people. You may give other people a serious infection or get a serious infection from them.

NARRATOR: Always use a new syringe and needle for each injection to prevent infections and blocked needles. Do not reuse or share your syringes or needles with other people. You may give other people a serious infection or get a serious infection from them.

We will now review the steps to inject your dose of Zepbound.

03:14-03:19

[A pair of hands move back and forth with bubbles animating in the background.]

CAPTION: Once weekly

Zepbound®

(tirzepatide) injection

A Lilly Medicine

Preparing for your Zepbound® injection

• Wash your hands

NARRATOR: Get ready for your injection by washing your hands with soap and water.

03:19-03:28

[A diagram of a person animates on screen, purple ovals highlighting the stomach area and thighs.]

CAPTION: Once weekly

Zepbound®

(tirzepatide) injection

A Lilly Medicine

Choose your injection site

• You or someone else can inject Zepbound under the skin of your stomach area (abdomen) or thighs

NARRATOR: Choose your injection site. You or someone else can inject Zepbound under the skin of your stomach area or abdomen or thighs.

03:28-03:45

[Purple ovals highlight the upper arms on the diagram of the person.]

CAPTION: Once weekly

Zepbound®

(tirzepatide) injection

A Lilly Medicine

Choose your injection site

• Someone else can give you the injection in the back of your upper arm

• Change (rotate) your injection site with each weekly injection. You may use the same area of your body but be sure to choose a different injection site in that area. Do not use the same site for each injection

NARRATOR: You can have another person give you the injection in the back of your upper arm. Change or rotate your injection site with each weekly injection. You may use the same area of your body, but be sure to choose a different injection site in that area. Do not use the same site for each injection.

03:45-03:54

[A person’s hands holding a Zepbound vial animate on screen. The hands remove the cap and wipe the rubber stopper with an alcohol swab.]

CAPTION: Once weekly

Zepbound®

(tirzepatide) injection

A Lilly Medicine

Prepare the vial

• Pull off the plastic protective cap
• Do not remove the rubber stopper
• Wipe the rubber stopper with the alcohol swab

NARRATOR: Begin by pulling off the plastic protective cap, but do not remove the rubber stopper. Wipe the rubber stopper with an alcohol swab.

03:54-03:59

[The hands remove the outer wrapping from a syringe and needle.]

CAPTION: Once weekly

Zepbound®

(tirzepatide) injection

A Lilly Medicine

Attach the syringe and needle

• Remove the outer wrapping from the syringe and needle

NARRATOR: Next, you will need to remove the outer wrapping from the syringe and needle.

03:59-04:09

[The needle twists onto the syringe until tight and firmly attached. A green arrow illustrates which direction to twist the needle.]

CAPTION: Once weekly

Zepbound®

(tirzepatide) injection

A Lilly Medicine

CAPTION: Attach the syringe and needle

• Remove the outer wrapping from the syringe and needle

• Attach the needle to the top of the syringe

NARRATOR: Place the needle on top of the syringe and turn until it is tight and firmly attached. You can omit this step if the needle and syringe are already attached.

04:09-04:13

[The hands pull the needle shield off the syringe. An arrow illustrates which direction to pull the needle shield in.]

CAPTION: Once weekly

Zepbound®

(tirzepatide) injection

A Lilly Medicine

Prepare the syringe and needle

• Remove the needle shield by pulling straight off

NARRATOR: Now, remove the needle shield by pulling it straight off.

04:13-04:27

[One hand holds the syringe pointing up while the other hand pulls down on the plunger. A graphic animates on screen, showing a close-up of the syringe and highlighting the plunger tip reaching the 0.5-mL line. A green arrow illustrates which direction to pull the plunger towards.]

CAPTION: Once weekly

Zepbound®

(tirzepatide) injection

A Lilly Medicine

Prepare the syringe and needle

• Hold the syringe pointed up

• Pull down until the plunger tip reaches 0.5 mL of air

NARRATOR: Hold the syringe in one hand with the needle pointing up. With the other hand, pull down on the plunger until the plunger tip reaches the line on the syringe indicating that 0.5 milliliters of air has been drawn into the syringe.

04:27-04:31

[One hand holds the vial while the other hand pushes the needle through the vial’s rubber stopper.]

CAPTION: Once weekly

Zepbound®

(tirzepatide) injection

A Lilly Medicine

Push the needle in

• Push the needle through the rubber stopper of the vial

NARRATOR: Then, push the needle through the rubber stopper of the vial.

04:31-04:37

[One hand holds the vial while the other hand pushes the plunger all the way into the vial.]

CAPTION: Once weekly

Zepbound®

(tirzepatide) injection

A Lilly Medicine

Push the plunger in

• Push the needle through the rubber stopper of the vial

• Push the plunger all the way in

• This puts air into the vial

NARRATOR: Push the plunger all the way in. This puts air into the vial and makes it easier to pull the solution from the vial.

04:37-04:50

[One hand holds the vial and syringe upside down. The other hand pulls the plunger down. A graphic animates on screen, showing a close-up of the syringe and highlighting the plunger tip extending beyond the 0.5-mL line.]

CAPTION: Once weekly

Zepbound®

(tirzepatide) injection

A Lilly Medicine

Fill the syringe

• Turn the vial and syringe upside down

• Pull the plunger down until the plunger tip is past 0.5 mL

Ensure the tip of the needle is in the liquid in the vial.

NARRATOR: Next, you will need to turn the vial and syringe upside down. Make sure that the tip of the needle is in the liquid and slowly pull the plunger down until the plunger tip is past the 0.5-milliliter line.

04:50-04:56

[One hand holds the vial and syringe upside down. The other hand flicks the syringe to remove air bubbles.]

CAPTION: Once weekly

Zepbound®

(tirzepatide) injection

A Lilly Medicine

Fill the syringe

• Tap the syringe if there are any air bubbles

NARRATOR: If there are air bubbles, tap the syringe gently a few times to let any air bubbles rise to the top.

04:56-05:03

[One hand holds the vial and syringe upside down. The other hand pushes the plunger up with its thumb. A graphic animates on screen, showing a close-up of the syringe and highlighting the plunger tip extending to the 0.5-mL line. A green arrow illustrates which direction to push the plunger in.]

CAPTION: Once weekly

Zepbound®

(tirzepatide) injection

A Lilly Medicine

Finish syringe preparation

• Push the plunger up until the plunger tip reaches 0.5 mL

NARRATOR: Then, slowly push the plunger up until the plunger tip reaches the 0.5-milliliter line.

05:03-05:07

[One hand holds the vial. The other hand pulls the syringe out of the vial.]

CAPTION: Once weekly

Zepbound®

(tirzepatide) injection

A Lilly Medicine

Finish syringe preparation

• Push the plunger up until the plunger tip reaches 0.5 mL
• Pull the syringe out

NARRATOR: Pull the syringe out of the rubber stopper of the vial.

05:07-05:19

[The Zepbound logo disappears from the lower right-hand corner. Holding their shirt up to reveal their stomach area, a person inserts the needle into their skin and pushes down on the plunger of the syringe—holding it in place for five seconds.]

CAPTION: Injecting the medicine

• Insert the needle into your skin

• Push down on the plunger

• The needle should stay in for at least 5 seconds

NARRATOR: Now, insert the needle into your skin and push down on the plunger to inject your dose. The needle should stay in your skin for at least five seconds to make sure you have injected all of your dose.

05:19-05:31

[The person pulls the needle out of their skin. A sharps container animates on screen. The needle and syringe drop safely into the container. The Zepbound logo re-appears on screen in the lower right-hand corner.]

CAPTION: Once weekly

Zepbound®

(tirzepatide) injection

A Lilly Medicine

Injecting the medicine

• Insert the needle into your skin

• Push down on the plunger

• The needle should stay in for at least 5 seconds

• Pull out the needle

• Do not recap the needle. Recapping the needle can lead to a needle stick injury

• Place the used needle and syringe directly into your FDA-cleared sharps container

NARRATOR: Pull the needle out of your skin. Do not recap the needle. Recapping the needle can lead to a needle stick injury. Place the needle and syringe directly into your sharps container.

05:31-05:41

[Holding their shirt up to reveal their stomach area, the person presses their injection site with an alcohol swab. The Zepbound logo disappears from the lower right-hand corner.]

CAPTION: Injecting the medicine

• If you see blood, press the injection site with a piece of gauze or alcohol swab

• Do not rub the area

NARRATOR: If you see blood after you take the needle out of your skin, press the injection site with a piece of gauze or an alcohol swab. Do not rub the area.

05:41-05:45

[A sharps container animates on screen. The Zepbound logo re-appears on screen in the lower right-hand corner.]

CAPTION: Once weekly

Zepbound®

(tirzepatide) injection

A Lilly Medicine

Disposing of used needles and syringes

• Do not throw away needles and syringes in your household trash

NARRATOR: Do not throw away needles and syringes in your household trash.

05:45-06:19

[The sharps container remains on screen. A green hazardous waste label animates on and off screen.]

CAPTION: Once weekly

Zepbound®

(tirzepatide) injection

A Lilly Medicine

Disposing of used needles and syringes

• If you do not have a sharps disposal container, you may use a household container that is:

• Made of a heavy-duty plastic

• Fit with a puncture-resistant lid that can be closed tightly without sharps being able to come out

• Upright and stable during use

• Leak-resistant

• Properly labeled to warn of hazardous waste inside the container

• Do not recycle your used sharps disposal container

• Keep Zepbound vials, syringes, needles, and all medicines out of the reach of children

NARRATOR: If you do not have an FDA-cleared sharps disposal container, you may use a household container that is made of a heavy-duty plastic, fit with a puncture-resistant lid that can be closed tightly without sharps being able to come out, upright and stable during use, leak-resistant, and properly labeled to warn of hazardous waste inside the container.

Do not recycle your used sharps disposal container. Follow your community guidelines for the right way to dispose of your sharps disposal container.

Keep Zepbound vials, syringes, needles, and all medicines out of the reach of children.

06:19-06:33

[Text animates on screen.]

CAPTION: If you have any questions about injecting Zepbound® (tirzepatide) or problems with your

Zepbound vial, contact your healthcare provider or Lilly at 1-800-LillyRx (1-800-545-5979).

For more information about Zepbound, visit our website at zepbound.lilly.com

Zepbound® and its delivery device base are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.

Zepbound is available by prescription only.

CMAT-19360 03/2026

©Lilly USA, LLC 2026. All rights reserved.

Once weekly

Zepbound®

(tirzepatide) injection

A Lilly Medicine

NARRATOR: If you have any questions or concerns about administering Zepbound, please contact your healthcare provider or Lilly at 1-800-LillyRx (1-800-545-5979).

06:33-14:51

[Text animates on screen and begins scrolling. The Zepbound logo animates on the upper right-hand corner of the screen.]

NARRATOR: Voice over generated by AI

CAPTION: Zepbound®

(tirzepatide) injection 0.5 mL or 0.6 mL

2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg

A Lilly Medicine

CAPTION: INDICATIONS AND SAFETY SUMMARY WITH WARNINGS

Zepbound® (ZEHP-bownd) is an injectable prescription medicine used with a reduced-calorie diet and increased physical activity to help adults with:

• obesity, or some adults with overweight who also have weight-related medical problems, to lose excess body weight and keep the weight off.

• moderate-to-severe obstructive sleep apnea (OSA) and obesity to improve their OSA.

Zepbound contains tirzepatide and should not be used with other tirzepatide-containing products or any GLP-1 receptor agonist medicines. It is not known if Zepbound is safe and effective for use in children.

Warnings - Zepbound may cause tumors in the thyroid, including thyroid cancer. Watch for possible symptoms, such as a lump or swelling in the neck, hoarseness, trouble swallowing, or shortness of breath. If you have any of these symptoms, tell your healthcare provider.

• Do not use Zepbound if you or any of your family have ever had a type of thyroid cancer called

medullary thyroid carcinoma (MTC).

• Do not use Zepbound if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).

• Do not use Zepbound if you have had a serious allergic reaction to tirzepatide or any of the

ingredients in Zepbound.

KwikPen®: Do not share your KwikPen with other people, even if the pen needle has been changed.  You may give other people a serious infection or get a serious infection from them.

Zepbound may cause serious side effects, including:

Severe stomach problems. Stomach problems, sometimes severe, have been reported in people who use Zepbound. Tell your healthcare provider if you have stomach problems that are severe or will not go away.

Dehydration leading to kidney problems. Diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration), which may cause kidney problems. It is important for you to drink fluids to help reduce your chance of dehydration. Tell your healthcare provider right away if you have nausea, vomiting, or diarrhea that does not go away.

Gallbladder problems. Gallbladder problems have happened in some people who use Zepbound. Tell your healthcare provider right away if you get symptoms of gallbladder problems, which may include pain in your upper stomach (abdomen), fever, yellowing of skin or eyes (jaundice), or clay-colored stools.

Inflammation of the pancreas (pancreatitis). Stop using Zepbound and call your healthcare provider right away if you have severe pain in your stomach area (abdomen) that will not go away, with or without nausea or vomiting. You may feel the pain from your abdomen to your back.

Serious allergic reactions. Stop using Zepbound and get medical help right away if you have any symptoms of a serious allergic reaction, including swelling of your face, lips, tongue or throat, problems breathing or swallowing, severe rash or itching, fainting or feeling dizzy, or very rapid heartbeat.

Low blood sugar (hypoglycemia). Your risk for getting low blood sugar may be higher if you use Zepbound with medicines that can cause low blood sugar, such as a sulfonylurea or insulin. Signs and symptoms of low blood sugar may include dizziness or light-headedness, sweating, confusion or drowsiness, headache, blurred vision, slurred speech, shakiness, fast heartbeat, anxiety, irritability, mood changes, hunger, weakness or feeling jittery.

Changes in vision in patients with type 2 diabetes. Tell your healthcare provider if you have changes in vision during treatment with Zepbound.

Food or liquid getting into the lungs during surgery or other procedures that use anesthesia or deep

sleepiness (deep sedation). Zepbound may increase the chance of food getting into your lungs during surgery or other procedures. Tell all your healthcare providers that you are taking Zepbound before you are scheduled to have surgery or other procedures.

Common side effects

The most common side effects of Zepbound include nausea, diarrhea, vomiting, constipation, stomach

(abdominal) pain, indigestion, injection site reactions, feeling tired, allergic reactions, belching, hair loss ,

and heartburn. These are not all the possible side effects of Zepbound. Talk to your healthcare provider about any side effect that bothers you or doesn’t go away.

Tell your doctor if you have any side effects. You can report side effects at 1-800-FDA-1088 or www.fda.gov/medwatch.

Before using Zepbound

• Your healthcare provider should show you how to use Zepbound before you use it for the first time.

• Talk to your healthcare provider about low blood sugar and how to manage it. Tell your

healthcare provider if you are taking medicines to treat diabetes including an insulin or

sulfonylurea.

• If you take birth control pills by mouth, talk to your healthcare provider before you use

Zepbound. Birth control pills may not work as well while using Zepbound. Your healthcare

provider may recommend another type of birth control for 4 weeks after you start Zepbound

and for 4 weeks after each increase in your dose of Zepbound.

Review these questions with your healthcare provider:

❑ Do you have other medical conditions, including problems with your pancreas, or

severe problems with your stomach, such as slowed emptying of your stomach (gastroparesis) or

problems digesting food?

❑ Do you take diabetes medicines, such as insulin or sulfonylureas?

❑ Do you have a history of diabetic retinopathy?

❑ Are you scheduled to have surgery or other procedures that use anesthesia or deep sleepiness (deep

sedation)?

❑ Do you take any other prescription medicines or over-the-counter drugs, vitamins, or herbal

supplements?

❑ Are you pregnant, plan to become pregnant, breastfeeding, or plan to breastfeed? Zepbound

may harm your unborn baby. Tell your healthcare provider if you become pregnant while using

Zepbound. Zepbound may pass into your breast milk. You should talk with your

healthcare provider about the best way to feed your baby while using Zepbound.

• Pregnancy Exposure Registry: There will be a pregnancy exposure registry for women who

have taken Zepbound during pregnancy. The purpose of this registry is to collect information

about the health of you and your baby. Talk to your healthcare provider about how you can

take part in this registry, or you may contact Lilly at 1-800-LillyRx (1-800-545-5979).

How to take

• Read the Instructions for Use that come with Zepbound.

• Use Zepbound exactly as your healthcare provider says.

• Use Zepbound with a reduced-calorie diet and increased physical activity.

• Inject Zepbound under the skin (subcutaneously) of your stomach (abdomen), thigh, or
  have another person inject in the back of the upper arm. Do not inject ZEPBOUND into a

muscle (intramuscularly) or vein (intravenously).

• Use Zepbound 1 time each week, at any time of the day.

• Change (rotate) your injection site with each weekly injection. Do not use the same site for each injection.

• If you take too much Zepbound, call your healthcare provider, call the Poison Help line at 1-800-222-1222 or go to the nearest hospital emergency room right away.

Zepbound is approved as a 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, and 15 mg injection.

Learn more

Zepbound is a prescription medicine. For more information, call 1-800-LillyRx (1-800-545-5979) or go

to www.zepbound.lilly.com.

This summary provides basic information about Zepbound but does not include all information known about this medicine. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your healthcare provider. Be sure to talk to your healthcare provider about Zepbound and how to take it. Your healthcare provider is the best person to help you decide if Zepbound is right for you.

ZP CON BS 25FEB2026

Lilly

A MEDICINE COMPANY

Zepbound^®, its delivery device base, and KwikPen^® are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.

14:51-14:54

[The Zepbound logo animates on screen.]

CAPTION: Zepbound^®

(tirzepatide) injection 0.5 mL or 0.6 mL

2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg

A Lilly Medicine

Visit Zepbound.com

or call 1-800-LillyRx (1-800-545-5979) for pricing information

14:54-14:59

[The Lilly logo animates on screen.]

CAPTION: Lilly

A MEDICINE COMPANY

CMAT-19360 03/2026 © Lilly USA, LLC 2026. All rights reserved.

Zepbound^® and its delivery device base are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.

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