Getting Patients Started
For adults with obesity (BMI of ≥30 kg/m2), or with overweight (BMI of ≥27 kg/m2) with at least 1 weight-related comorbidity.1
Here's what to do:
Access Additional Start Resources
What's needed to begin prescribing Zepbound?
- Initiate with the 2.5-mg dose1
- After 4 weeks, increase to the 5-mg dose1
Multiple doses to help individualize treatment with Zepbound1
Recommended maintenance dosages are 5 mg, 10 mg, or 15 mg1:
You can continue to increase the dose by 2.5-mg increments after at least 4 weeks on the current dose. The maximum dose is 15 mg.1
- Consider treatment response and tolerability when selecting maintenance dosage. If not tolerated, consider a lower maintenance dosage
For adults with obesity (BMI of ≥30 kg/m2) or with overweight (BMI of ≥27 kg/m2) with at least 1 weight-related comorbidity.1
The 2.5-mg dosage is for treatment initiation and is not intended for chronic weight management.1
Relevant product information for pharmacists
Download GuidePatients can experience Zepbound for as low as $25 for a 1-month, 2- month, or 3-month* prescription if they are eligible and commercially insured with coverage for Zepbound.
Governmental beneficiaries excluded, terms and conditions apply.
Eligible patients with commercial insurance without coverage may pay as low as $550† for a 1-month prescription.
†Estimated payment based on savings of up to $563 per month.
Governmental beneficiaries excluded, terms and conditions apply.
*One month is defined as 28 days and 4 pens. Two months is defined as 56 days and up to 8 pens. Three months is defined as 84 days and up to 12 pens.
Access the Zepbound Savings Card for your eligible and commercially insured patients.
Curious about your patient's coverage?
Send them to www.zepbound.lilly.com
Terms and Conditions
REMIND Patients that Zepbound is administered using a single-dose pen. There is no need to see or handle the needle2*
ADVISE Patients to read the Instructions for Use3
ALLOW Patients to practice the injection using the demonstration device
CONSIDER having patients administer the first dose in the office
DISCUSS SAFETY profile and that Zepbound may cause some side effects†
For example, patients may experience nausea, diarrhea, or vomiting.1
In order to mitigate these gastrointestinal side effects, they may find it helpful to4-6:
- Eat smaller meals—suggest that they split 3 daily meals into 4 or more smaller meals
- Stop eating when they feel full
- Avoid fatty foods
- Try eating bland foods
Encourage patients to continue to drink plenty of water and eat healthy meals to ensure they meet their needs for protein, micronutrients, fiber, and fluids
RECOMMEND that patients who are using oral hormonal contraceptives switch to a non-oral contraceptive method, or add a barrier method of contraception, for 4 weeks after initiation with Zepbound and for 4 weeks after each dose escalation. Zepbound delays gastric emptying, so it may make oral contraceptives less effective.1
For adults patients with obesity (BMI ≥30 kg/m2) or overweight (BMI ≥27 kg/m2) with at least 1 weight-related comorbidity.1
Watch how to use the Zepbound pen
Share this patient injection video with your patient to help them get familiar with self-injecting Zepbound.
Patients can text ZB to 85099 to enroll for a digital starter kit to help them get started on Zepbound.
The Digital Starter Kit provides tips for starting Zepbound, what to expect, reminder options, and additional resources.