Learn the latest information on availability of this Lilly Medicine.
Learn how to identify compounded/counterfeit tirzepatide and its potential risks.
For adults with obesity or with excess weight and weight-related medical problems
Zepbound means change
Proven to help adults with obesity lose weight and keep it off, along with a reduced-calorie diet and increased physical activity.
For adults with obesity or with excess weight and weight-related medical problems
Zepbound means change
Proven to help adults with obesity lose weight and keep it off, along with a reduced-calorie diet and increased physical activity.
What is Zepbound?
Zepbound is an injectable prescription medicine that may help adults with obesity, or with excess weight (overweight) who also have weight-related medical problems, lose weight and keep it off. Zepbound should be used with a reduced-calorie diet and increased physical activity.
- Zepbound contains tirzepatide and should not be used with other tirzepatide-containing products or any GLP-1 receptor agonist medicines.
- It is not known if Zepbound is safe and effective when taken with other prescription, over-the-counter, or herbal weight loss products.
- It is not known if Zepbound can be used in people who have had pancreatitis.
- It is not known if Zepbound is safe and effective for use in children under 18 years of age.
People taking
Zepbound 15 mg lost
up
to
(~21% weight loss)*
Individual results may vary.
Throughout a 17-month clinical trial, people who took Zepbound sustained weight loss—whether taking the 5-mg, 10-mg, or 15-mg dose.*†
Zepbound is not for cosmetic weight loss.
*Along with diet and exercise.
†In a 72-week study of adults without diabetes, average weight loss was 15.0% (34 lbs) for 5 mg, 19.5% (44 lbs) for 10 mg, 20.9% (48 lbs) for 15 mg, and 3.1% (7 lbs) for placebo. Average starting weights were 226.8 lbs for 5 mg, 233.3 lbs for 10 mg, 232.8 lbs for 15 mg, and 231.0 lbs for placebo. In a 72-week study of adults with diabetes, average weight loss was 12.8% (28 lbs) for 10 mg, 14.7% (33 lbs) for 15 mg, and 3.2% (7 lbs) for placebo. Average starting weights were 222.4 lbs for 10 mg, 219.6 lbs for 15 mg, and 224.2 lbs for placebo.
Select Safety Information
Warning:
Tell your healthcare provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In studies with rats, Zepbound and medicines that work like Zepbound caused thyroid tumors, including thyroid cancer. It is not known if Zepbound will cause thyroid tumors, or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people. Do not take Zepbound if you or any of your family have ever had MTC or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
Additional health measures
In a 17-month clinical trial, people who dieted, exercised, and took Zepbound observed changes in:‡§
Cholesterol
Blood pressure
Waist size
Some people taking Zepbound also experienced an increase in resting heart rate.
‡Zepbound is not for the treatment of cholesterol or blood pressure.
§Diet and exercise included a reduced-calorie meal plan and increased physical activity.
Waist size=waist circumference.
Select Safety Information
Do not use Zepbound if you or any of your family have ever had a type of thyroid cancer called MTC or if you have an endocrine system condition called MEN 2, or if you have had a serious allergic reaction to tirzepatide or any of the ingredients in Zepbound.
Real Zepbound stories
Zepbound in her words
00:00-00:05
[Animated intro sequence appears]
CAPTION: Before Janeth’s story, please see the safety information.
00:05-00:09 [Animated intro sequence with Zepbound Logo appears]
CAPTION: once weekly Zepbound® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5mg |
15mg
A Lilly Medicine
visit www.zepbound.lilly.com or call 1-800-LillyRx for pricing information
00:09-00:52
[Opening indication appears and remains on-screen until the narrator concludes]
NARRATOR: Zepbound is an injectable prescription medicine that may help adults with obesity, or with
excess weight (overweight) who also have weight-related medical problems, lose weight and keep it off.
Zepbound should be used with a reduced-calorie diet and increased physical activity.
Zepbound contains tirzepatide and should not be used with other tirzepatide-containing products or any
GLP-1
receptor agonist medicines. It is not known if Zepbound is safe and effective when taken with other
prescription, over-the-counter, or herbal weight loss products. It is not known if Zepbound can be used in
people who have had pancreatitis. It is not known if Zepbound is safe and effective for use in children
under
18 years of age.
00:53-01:34
NARRATOR: Select Safety Information. Warning. Tell your healthcare provider if you get a lump or
swelling
in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid
cancer.
In studies with rats, Zepbound and medicines that work like Zepbound caused thyroid tumors, including
thyroid
cancer. It is not known if Zepbound will cause thyroid tumors, or a type of thyroid cancer called
medullary
thyroid carcinoma (MTC) in people. Do not take Zepbound if you or any of your family have ever had MTC or
if
you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
CAPTION: See Indication and Safety Summary with Warnings at the end of this video.
01:37-01:57
[Ambient music, ocean waves, and seagull sounds play in the background; Janeth walking along the beach]
CAPTION: Janeth was a clinical trial patient and was compensated for her time.
JANETH: I tried so many things to lose weight, and I couldn't. I felt stuck in my situation.
01:57-02:17
[Ambient music continues while photos of Janeth and her family are shown]
JANETH: All my thought was food. Morning, afternoon, at night. Maybe I ate lunch, and half an hour to one
hour
and a half, I was hungry again. When everybody sleeping,
02:17-02:22
[Janeth speaking to the camera]
JANETH: I got hungry at one or two o'clock in the morning. I had to get up, go to the fridge
02:22-02:26
[Janeth walking along the beach]
JANETH: and get something. And when I finish from work,
02:26-02:36
Janeth speaking to the camera]
JANETH: I pass by restaurants or fast food, and I get something for me before then I go home. When I go
home, I cook, and I eat again.
02:36-02:42
[Janeth walking along the beach]
JANETH: My struggle with the weight started after having my second kid. Before I have a kid,
02:42-02:48
[Photos of Janeth and her family are shown]
JANETH: I will say I was on average size, probably six or eight. Then one day I found out myself as size 18.
02:48-2:54
[Janeth is on-screen speaking, looking at a photo of her and her sister]
JANETH: When I see this picture is, it's me and my sister on my birthday.
02:54-2:58
[Close-up of the photo of her and her sister]
JANETH: It's sad to see that picture, really.
02:58-03:03
[Janeth is on-screen speaking, looking at a photo of her and her sister]
JANETH: I would, I would love to erase it, but only because my sister there. I don’t like, I don't want to erase it,
03:03-03:07
[Close-up of the photo of her and her sister]
JANETH: but it's me. It was me.
03:07-3:21
[Janeth is on screen speaking to the camera; emotional]
JANETH: It's so sad. Sorry. So sad to be 30 years in your life for your weight. You’re hiding. You
don't do anything. You miss so much time on your family.
03:21-3:27
[Ambient music fades out; Janeth walking into her bedroom]
JANETH: So, years passed by, and now that I'm my age,
03:27-3:29
[Janeth walks into the bedroom and opens the curtains]
JANETH: I feel like, I want to do something.
03:29-03:37
[Inspirational music plays in the background; Janeth walks into the kitchen with a grocery bag]
CAPTION: Individual results may vary. Talk to your doctor to see if Zepbound® is right for you.
JANETH: When I did the trial, it take away the desire of food.
03:37-03:44
[Janeth is putting the groceries away in her kitchen]
Throughout a 17-month clinical trial, people who dieted, exercised,* and took Zepbound sustained weight
loss—whether taking the 5-mg, 10-mg, or 15-mg dose.†
CAPTION: Zepbound is not for cosmetic weight loss.
Along with reduced-calorie diet and increased physical activity.
Individual results may vary. In studies, average weight loss in adults with or without diabetes was ~15%
(34
lbs) on 5 mg, ~13-20% (28-44 lbs) on 10 mg, and ~15-21% (33-48 lbs) on 15 mg compared to ~3% (7 lbs) on
placebo. Avg. baseline weights were ~220-233 Ibs.
JANETH: I was eating healthy and exercise. During 72 weeks, I was able to lose significant weight and
maintain
weight loss.
03:44-03:48
[Janeth on screen talking to the camera]
Throughout a 17-month clinical trial, people who dieted, exercised,* and took Zepbound sustained weight
loss—whether taking the 5-mg, 10-mg, or 15-mg dose.†
CAPTION: Zepbound is not for cosmetic weight loss.
Along with reduced-calorie diet and increased physical activity.
Individual results may vary. In studies, average weight loss in adults with or without diabetes was ~15%
(34
lbs) on 5 mg, ~13-20% (28-44 lbs) on 10 mg, and ~15-21% (33-48 lbs) on 15 mg compared to ~3% (7 lbs) on
placebo. Avg. baseline weights were ~220-233 Ibs.
JANETH: My size, it was, it was going low. Like size 16,
03:48-03:51
[Janeth sorts through clothes on a clothing rack]
Throughout a 17-month clinical trial, people who dieted, exercised,* and took Zepbound sustained weight
loss—whether taking the 5-mg, 10-mg, or 15-mg dose.†
CAPTION: Zepbound is not for cosmetic weight loss.
Along with reduced-calorie diet and increased physical activity.
Individual results may vary. In studies, average weight loss in adults with or without diabetes was ~15%
(34
lbs) on 5 mg, ~13-20% (28-44 lbs) on 10 mg, and ~15-21% (33-48 lbs) on 15 mg compared to ~3% (7 lbs) on
placebo. Avg. baseline weights were ~220-233 Ibs.
JANETH: it went down to 14, and after that,
03:51-03:53
[Janeth picks out a coral top and holds it up against herself while looking in the mirror]
CAPTION: Zepbound is not for cosmetic weight loss.
Along with diet and exercise.
Individual results may vary. In studies, average weight loss in adults with or without diabetes was ~15%
(34
lbs) on 5 mg, ~13-20% (28-44 lbs) on 10 mg, and ~15-21% (33-48 lbs) on 15 mg compared to ~3% (7 lbs) on
placebo. Avg. baseline weights were ~220-233 Ibs.
JANETH: I went down to 12, and I now it's size eight.
03:53-04:02
[Janeth washes vegetables. Janeth on screen talking to the camera]
CAPTION: Zepbound is not for cosmetic weight loss.
Along with diet and exercise.
Individual results may vary. In studies, average weight loss in adults with or without diabetes was ~15%
(34
lbs) on 5 mg, ~13-20% (28-44 lbs) on 10 mg, and ~15-21% (33-48 lbs) on 15 mg compared to ~3% (7 lbs) on
placebo. Avg. baseline weights were ~220-233 Ibs.
JANETH: Before I, when I was overweight, my mind all the times think about food. Always.
04:02-04:03
[Janeth cutting vegetables]
CAPTION: Zepbound is not for cosmetic weight loss.
Along with diet and exercise.
Individual results may vary. In studies, average weight loss in adults with or without diabetes was ~15%
(34
lbs) on 5 mg, ~13-20% (28-44 lbs) on 10 mg, and ~15-21% (33-48 lbs) on 15 mg compared to ~3% (7 lbs) on
placebo. Avg. baseline weights were ~220-233 Ibs.
JANETH: I look for excuse to and tell my kids,
04:04-04:08
[Janeth on screen talking to the camera]
CAPTION: Zepbound is not for cosmetic weight loss.
Along with diet and exercise.
Individual results may vary. In studies, average weight loss in adults with or without diabetes was ~15%
(34
lbs) on 5 mg, ~13-20% (28-44 lbs) on 10 mg, and ~15-21% (33-48 lbs) on 15 mg compared to ~3% (7 lbs) on
placebo. Avg. baseline weights were ~220-233 Ibs.
JANETH: "You want something? You want something? Okay, I cook something for you." When I cook
something for them,
04:08-04:09
[Janeth cutting vegetables]
CAPTION: Zepbound is not for cosmetic weight loss.
Along with diet and exercise.
Individual results may vary. In studies, average weight loss in adults with or without diabetes was ~15%
(34
lbs) on 5 mg, ~13-20% (28-44 lbs) on 10 mg, and ~15-21% (33-48 lbs) on 15 mg compared to ~3% (7 lbs) on
placebo. Avg. baseline weights were ~220-233 Ibs.
JANETH: and for me.
04:09-04:16
[Janeth on screen talking to the camera]
JANETH: Now, really, I can cook and do everything, and it doesn't feel like I want to eat. I have the
control.
04:16-04:18
[Janeth puts chopped vegetables in a bowl]
04:18-04:21
[Janeth mixes something in a saucepan]
JANETH: Since
04:21-04:22
[Janeth seasons salmon]
JANETH: losing weight,
04:23-04:24
[Janeth smiles and pours olive oil in a bowl]
JANETH: I'm more active now.
04:24-04:27
[Janeth adds seasoning to the bowl]
JANETH: Like I go to the pool, go to the park, go to the movie.
04:27-04:30
[Janeth places food on the grill]
Somebody invite me for party, like my family, I go,
04:30-04:31
[Janeth brings a plate of food over to a table]
JANETH: I go to them.
04:31-04:43
[Janeth smiling at an outdoor table during a meal]
04:33-04:34
[Janeth’s husband smiling at a table during a meal]
04:34-04:36
[Janeth and her sister take a selfie at the table]
04:36-04:38
[Janeth smiling into the camera]
JANETH: I feel happy when I see myself in the mirror.
04:38-04:42
[Janeth replaces the photo of her and her sister with a new photo]
JANETH: I am excited about where I am today
04:42-04:46
[We see the new photo Janeth has placed is the selfie with her sister taken at dinner]
JANETH: and where I want to go. I would like to
04:46-04:56
[Janeth on screen speaking to the camera]
JANETH: go back to school, finish my degree. I would like to lose more weight. I would like to have more
time
with my kids, my grandkids.
04:56-04:59
[Janeth puts on headphones on the beach]
JANETH: I will tell you it's a hope to lose weight.
04:59-05:07
Janeth is power walking on the beach]
JANETH: If I did it, you can do it. I am still on my journey, and I'm not finished.
05:07-05:14
[Janeth is walking toward the camera on the beach]
JANETH: I am hopeful about where I am going.
05:14-05:19
[Janeth smiling at the camera while on the beach]
JANETH: I am unstoppable.
05:20-05:25
[Animated Zepbound logo appears on screen]
CAPTION: once weekly Zepbound® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5mg |
15mg
A Lilly Medicine visit www.zepbound.lilly.com or call 1-800-LillyRx for pricing information
05:20-05:31
[Animated Lilly Medicine logo appears on screen]
CAPTION: Lilly
A MEDICINE COMPANY
05:31-06:23
[Animated data and safety claims appear on screen]
CAPTION: INDICATION AND SAFETY SUMMARY WITH WARNINGS
once weekly Zepbound® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5mg | 15mg
NARRATOR: Indication and Safety Summary with Warnings. Zepbound® is an injectable prescription medicine
that
may help adults with obesity, or with excess weight (overweight) who also have weight-related medical
problems, lose weight and keep it off. It should be used with a reduced-calorie diet and increased
physical
activity. Zepbound contains tirzepatide and should not be used with other tirzepatide-containing products
or
any GLP-1 receptor agonist medicines. It is not known if Zepbound is safe and effective when taken with
other
prescription, over-the-counter, or herbal weight loss products. It is not known if Zepbound can be used in
people who have had pancreatitis. It is not known if Zepbound is safe and effective for use in children
under
18 years of age.
06:23-7:40
CAPTION: INDICATION AND SAFETY SUMMARY WITH WARNINGS
once weekly Zepbound® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5mg | 15mg
NARRATOR: Warnings. Zepbound may cause tumors in the thyroid, including thyroid cancer. Watch for possible
symptoms, such as a lump or swelling in the neck, hoarseness, trouble swallowing, or shortness of breath.
If
you have any of these symptoms, tell your healthcare provider. Do not use Zepbound if you or any of your
family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC). Do not use
Zepbound if
you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Do not use Zepbound if you have had a
serious
allergic reaction to tirzepatide or any of the ingredients in Zepbound. Zepbound may cause serious side
effects, including, severe stomach problems. Stomach problems, sometimes severe, have been reported in
people
who use Zepbound. Tell your healthcare provider if you have stomach problems that are severe or will not
go
away. Kidney problems (kidney failure). Diarrhea, nausea, and vomiting may cause a loss of fluids
(dehydration), which may cause kidney problems. It is important for you to drink fluids to help reduce
your
chance of dehydration.
07:40-9:17
CAPTION: INDICATION AND SAFETY SUMMARY WITH WARNINGS
once weekly Zepbound® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5mg | 15mg
NARRATOR: Gallbladder problems. Gallbladder problems have happened in some people who use Zepbound. Tell
your
healthcare provider right away if you get symptoms of gallbladder problems, which may include pain in your
upper stomach (abdomen), fever, yellowing of skin or eyes (jaundice), or clay-colored stools. Inflammation
of
the pancreas (pancreatitis). Stop using Zepbound and call your healthcare provider right away if you have
severe pain in your stomach area (abdomen) that will not go away, with or without vomiting. You may feel
the
pain from your abdomen to your back. Serious allergic reactions. Stop using Zepbound and get medical help
right away if you have any symptoms of a serious allergic reaction, including swelling of your face, lips,
tongue or throat, problems breathing or swallowing, severe rash or itching, fainting or feeling dizzy, or
very
rapid heartbeat. Low blood sugar (hypoglycemia). Your risk for getting low blood sugar may be higher if
you
use Zepbound with medicines that can cause low blood sugar, such as a sulfonylurea or insulin. Signs and
symptoms of low blood sugar may include dizziness or light-headedness, sweating, confusion or drowsiness,
headache, blurred vision, slurred speech, shakiness, fast heartbeat, anxiety, irritability, mood changes,
hunger, weakness or feeling jittery.
09:17-10:11
CAPTION: INDICATION AND SAFETY SUMMARY WITH WARNINGS
once weekly Zepbound® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5mg | 15mg
NARRATOR: Changes in vision in patients with type 2 diabetes. Tell your healthcare provider if you have
changes in vision during treatment with Zepbound. Depression or thoughts of suicide. You should pay
attention to changes in your mood, behaviors, feelings or thoughts. Call your healthcare provider right
away
if you have any mental changes that are new, worse, or worry you. Common side effects. The most common
side
effects of Zepbound include nausea, diarrhea, vomiting, constipation, stomach (abdominal) pain,
indigestion,
injection site reactions, feeling tired, allergic reactions, belching, hair loss, and heartburn. These are
not
all the possible side effects of Zepbound. Talk to your healthcare provider about any side effect that
bothers
you or doesn’t go away.
10:11-11:15
CAPTION: INDICATION AND SAFETY SUMMARY WITH WARNINGS
once weekly Zepbound® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5mg | 15mg
NARRATOR: Tell your healthcare provider if you have any side effects. You can report side effects at
1-800-FDA-1088 or www.fda.gov/medwatch. Before using Zepbound. Your healthcare provider should show you
how to
use Zepbound before you use it for the first time. Tell your healthcare provider if you are taking
medicines
to treat diabetes including insulin or sulfonylureas which could increase your risk of low blood sugar.
Talk
to your healthcare provider about low blood sugar levels and how to manage them. If you take birth control
pills by mouth, talk to your healthcare provider before you use Zepbound. Birth control pills may not work
as
well while using Zepbound. Your healthcare provider may recommend another type of birth control for 4
weeks
after you start Zepbound and for 4 weeks after each increase in your dose of Zepbound.
11:15-12:08
CAPTION: INDICATION AND SAFETY SUMMARY WITH WARNINGS
once weekly Zepbound® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5mg | 15mg
NARRATOR: Review these questions with your healthcare provider. Do you have other medical conditions,
including problems with your pancreas or kidneys, or severe problems with your stomach, such as slowed
emptying of your stomach (gastroparesis) or problems digesting food? Do you take diabetes medicines, such
as
insulin or sulfonylureas? Do you have a history of diabetic retinopathy? Do you take any other
prescription
medicines or over-the-counter drugs, vitamins, or herbal supplements? Are you pregnant, plan to become
pregnant, breastfeeding, or plan to breastfeed? Zepbound may harm your unborn baby. Tell your healthcare
provider if you become pregnant while using Zepbound. It is not known if Zepbound passes into your breast
milk. You should talk with your healthcare provider about the best way to feed your baby while using
Zepbound.
12:09-13:23
CAPTION: INDICATION AND SAFETY SUMMARY WITH WARNINGS
once weekly Zepbound® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5mg | 15mg
NARRATOR: Pregnancy Exposure Registry. There will be a pregnancy exposure registry for women who
have
taken Zepbound during pregnancy. The purpose of this registry is to collect information about the health
of
you and your baby. Talk to your healthcare provider about how you can take part in this registry, or you
may
contact Lilly at 1-800-LillyRx (1-800-545-5979). How to take. Read the Instructions for Use that come with
Zepbound. Use Zepbound exactly as your healthcare provider says. Zepbound is injected under the skin
(subcutaneously) of your stomach (abdomen), thigh, or upper arm. Use Zepbound 1 time each week, at any
time of
the day. Change (rotate) your injection site with each weekly injection. Do not use the same site for each
injection. If you take too much Zepbound, call your healthcare provider, seek medical advice promptly, or
contact a Poison Center expert right away at 1-800-222-1222.
13:24-14:09
CAPTION: INDICATION AND SAFETY SUMMARY WITH WARNINGS
once weekly Zepbound® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5mg | 15mg
NARRATOR: Learn more. Zepbound is a prescription medicine. For more information, call 1-800-LillyRx
(1-800-545-5979) [or go to www.zepbound.lilly.com]. This summary provides basic information about Zepbound
but
does not include all information known about this medicine. Read the information that comes with your
prescription each time your prescription is filled. This information does not take the place of talking
with
your healthcare provider. Be sure to talk to your healthcare provider about Zepbound and how to take it.
Your
healthcare provider is the best person to help you decide if Zepbound is right for you.
14:09 -14:17
CAPTION: INDICATION AND SAFETY SUMMARY WITH WARNINGS
once weekly Zepbound® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5mg | 15mg
CAPTION: ZP CON CBS 08NOV2023. Zepbound® and its delivery device base are registered trademarks
owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.
14:18-14:20
[Animated Zepbound logo appears on screen]
CAPTION: once weekly Zepbound® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5mg | 15mg
A Lilly Medicine
visit www.zepbound.lilly.com or call 1-800-LillyRx for pricing information
14:20-14:22
[Animated Lilly Medicine logo appears on screen]
CAPTION: Lilly
A MEDICINE COMPANY
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