Patient Stories | Zepbound® (tirzepatide)

What is Zepbound?

Zepbound is an injectable prescription medicine that may help adults with obesity, or some adults with overweight who also have weight-related medical problems, to lose excess body weight and keep the weight off. Zepbound should be used with a reduced-calorie diet and increased physical activity.

Zepbound contains tirzepatide and should not be used with other tirzepatide-containing products or any GLP-1 receptor agonist medicines.
It is not known if Zepbound is safe and effective for use in children.

Select Safety Information

Warning:

Tell your healthcare provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In studies with rats, Zepbound and medicines that work like Zepbound caused thyroid tumors, including thyroid cancer. It is not known if Zepbound will cause thyroid tumors, or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people. Do not take Zepbound if you or any of your family have ever had MTC or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).

Real Zepbound stories

Hear from real patients on their own weight loss journeys.

00:00-00:04
[Animated intro sequence appears.]
CAPTION: Please see the safety information before Tim Bo's story.

00:04-00:50
[Animated intro sequence with Zepbound Logo appears]
CAPTION: once weekly zepbound^® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5 mg | 15 mg

[Opening indications appears and remains on-screen until the narrator concludes]

NARRATOR: Indications and Safety Summary with Warnings. Zepbound is an injectable prescription medicine that may help adults with obesity, or some adults with overweight who also have weight-related medical problems, to lose excess body weight and keep the weight off. It may also help adults with moderate-to-severe obstructive sleep apnea (OSA) and obesity to improve their OSA. It should be used with a reduced-calorie diet and increased physical activity.

Zepbound contains tirzepatide and should not be used with other tirzepatide-containing products or any GLP-1 receptor agonist medicines. It is not known if Zepbound is safe and effective for use in children.

00:50-1:32
CAPTION: Select Safety Information. Warning.
Narrator: Select Safety Information. Tell your healthcare provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In studies with rats, Zepbound and medicines that work like Zepbound caused thyroid tumors, including thyroid cancer. It is not known if Zepbound will cause thyroid tumors, or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people. Do not take Zepbound if you or any of your family have ever had MTC or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
NARRATOR: See Indication and Safety Summary with Warnings at the end of this video.

CAPTION: See Indication and Safety Summary with Warnings at the end of this video.

1:32-1:42
[Tim Bo hits the alarm clock; video pans to Tim Bo sipping his morning coffee.]
CAPTION: Tim Bo is a Zepbound clinical trial participant and was compensated for his time. Individual results may vary. Talk to your doctor to see if Zepbound^® is right for you.
TIM BO: When I get up at 5:00 am, that is Tim Bo time... That's me time. It gives me an opportunity to pour into myself. It's my solitude time.

1:42-1:50
[Tim Bo in his salon speaking to camera; video pans to Tim Bo putting on his shoes.]
TIM BO: I love to start the day with a good cup of coffee. From there, I grab my workout partner, my dog, Princess.

1:50-1:56
[Tim Bo’s dog princess runs up to greet Tim Bo as he finishes tying his shoes. They leash up and walk toward the door.]
TIM BO: She actually holds me accountable. I can look over and the first thing that she’s gonna do is she’s like...”

1:56-2:05
[Tim Bo in his salon speaking to camera; video pans to Tim Bo jogging with Princess in the neighborhood.]
TIM BO: ‘We’re ready to go?’ We’re ready to go. And we’re out there hitting the neighborhood.

2:05-2:12
[Overhead shot of high school football field; video pans to eye-level view of track; Tim Bo jogging on the track.]
TIM BO: To be able to run and to be able to move has always been a superpower for me. In high school, I ran track...

2:12-2:15
[Tim Bo shrugging in front of the camera.]
TIM BO: ...and I was at the top of my game. And then...

2:15-2:18
[Tim Bo in his salon speaking to the camera.]
TIM BO: ...I turned 18...and then (laughs)

2:18-2:24
[Tim Bo walking on the track; video pans to Tim Bo standing on the track in front of bleachers.]
TIM BO: When I went off to college, I didn’t keep up with my running. They talk about the freshman 15...

2:24-2:26
[Tim Bo in his salon speaking to camera.]
TIM BO: I put on the freshman 30.

2:26-2:30
[Tim Bo looking out onto the track; Tim Bo runs over the camera as it transitions to next scene.]
TIM BO: And over the years, I definitely started to feel it.

2:30-2:40
[Tim Bo watching old photos on the projector.]
TIM BO: Life happened, and I got married. Had my beautiful baby girl. And all that time, I just kept putting on weight. I noticed that my blood pressure kept getting higher.

2:40-2:46
[Tim Bo continues watching old photos from his past on a projector.]
TIM BO: With my clothes, I was always having to go a size up. What really got me was...

2:46-2:53
[Video pans from Tim Bo’s shoes up to him working with a client in his salon; video pans to Tim Bo in his salon looking at an old picture in the mirror and reflecting]
TIM BO: I’m a stylist and I do fashion shows. And I saw a picture of me that caught me from the side. It showed me how much weight...

2:53-3:04
[Tim Bo walks out on to the football field/track; shots of Tim Bo on the track.]
TIM BO: ...I actually put on. I remember I couldn’t breathe I was so out of breath. I remember being a little bit on the dizzy side because I was so exhausted. That photo hurt.

3:04-3:13
[Tim Bo in his salon; video pans to him looking out on the track; close up of Tim Bo reflecting; pans to aerial of Tim Bo on the bleachers.]
TIM BO: It shook me. But it allowed me to see the truth. That was the point I knew I had to change something.

3:13-3:23
[Tim Bo doing light exercises in a gym; video pans to Tim Bo drinking water and other activities in the gym.]
TIM BO: In the past, I tried everything. I had a personal trainer. Went to gyms. I even built a gym in my garage.

3:23-3:31
[Tim Bo continues doing light exercises in the gym.]
TIM BO: I was always dedicated to doing something, but I couldn’t get the lasting results that I was looking for.

3:31-3:38
[Tim Bo cutting and styling a client’s hair.]
TIM BO: I make a living making people look and feel good. I needed to find a way to pour back into myself.

3:38-3:52
[Tim Bo styling his client’s hair; pans to Tim Bo in his salon speaking to camera; video pans to Tim Bo doing a photo shoot in his salon.]
TIM BO: When I went to my doctor, I had a full-on assessment. She also explained to me that obesity is a real disease and that I may need a little bit more help than diet and exercise alone. And that’s when I was introduced to Zepbound.

3:52-3:56
[Tim Bo doing a photo shoot in his salon; Tim Bo holding a plate of food, smiling at camera.]
CAPTION: Individual results may vary. Talk to your doctor to see if Zepbound ^® is right for you.
TIM BO: Since starting Zepbound, along with diet and exercise, I have lost...

3:56-4:02 [Tim Bo looking proud at the track; Tim Bo laughing and styling his client’s hair.]
CAPTION: Throughout a 17-month clinical trial, people who dieted, exercised,* and took Zepbound sustained weight loss—whether taking the 5-mg, 10-mg, or 15-mg dose. †
Zepbound is not for cosmetic weight loss.
^*Along with reduced-calorie diet and increased physical activity.
^†Individual results may vary. In studies, average weight loss in adults with or without diabetes was ~15% (34 lbs) on 5 mg, ~13-20% (28-44 lbs) on 10 mg, and ~15-21% (33-48 lbs) on 15 mg compared to ~3% (7 lbs) on placebo. Avg. baseline weights were ~220-233 lbs.
TIM BO: ...a significant amount of weight. And I’m keeping it off. I’m not as hungry.

4:02-4:09
[Tim Bo styling his client’s hair.]
CAPTION: Zepbound is not for cosmetic weight loss.
^*Along with reduced-calorie diet and increased physical activity.
^†Individual results may vary. In studies, average weight loss in adults with or without diabetes was ~15% (34 lbs) on 5 mg, ~13-20% (28-44 lbs) on 10 mg, and ~15-21% (33-48 lbs) on 15 mg compared to ~3% (7 lbs) on placebo. Avg. baseline weights were ~220-233 lbs.
TIM BO I’m eating smaller, more nutritious portions and it’s working. I’ve gone from a 2XL to a Large.:

4:09-4:15
[Tim Bo in his salon chair; pans to Tim Bo jogging at the track and then smiling at camera.]
TIM BO: I get up every morning, I jog and workout in my gym at home.

4:15-4:23
[Tim Bo walking along the beach; pans to drone shot of Tim Bo on the beach.]
TIM BO: I love to go to the beach and just listen to the waves. It is perfect for meditation and relaxation.

4:23-4:36
[Tim Bo walking his dog, Princess; pans to Tim Bo speaking straight to camera from salon chair; Tim Bo smiling and enjoying the moment at the beach.]
TIM BO: I went to my regular doctor and she told me the weight loss is helping. And I’m sitting back and I’m asking myself, why did it take so long to do this?

4:36-4:44
[Tim Bo posing all dressed up for a photo shoot; pans to Tim Bo sitting in salon chair, then back to posing; pans to Tim Bo laughing in the salon chair]
TIM BO: I’m noticing changes now...So I’m enjoying these little moments that are happening, like not having to bend over to see my shoes.

4:44-4:54
[Tim Bo at the photo shoot; pans to Tim Bo speaking to camera in his salon chair.]
TIM BO: I really, really love who I see. As a southern guy, we pour into family and friends. We never put ourselves up front.

4:54-4:57
[Tim Bo looking at camera on the track smiling.]
TIM BO: I’m bound for pouring back into myself.

4:57-5:05
[Tim Bo enjoying a moment on the beach; video pans to Tim Bo in his salon talking to camera. Tim Bo jogging.]
TIM BO: This is my year. The year of Tim Bo. I’m gonna let y’all in on a little secret, y’all. I’m just getting started.

5:05-5:10
[Tim Bo jogging.]
[Animated boundfor logo appears on screen.]

5:10-5:12
[Zepbound end card appears on screen]
CAPTION: once weekly zepbound^® (tirzepatide) injection 0.5 mL 2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg
Visit www.zepbound.lilly.com or call 1-800-LillyRX
A Lilly Medicine
PP-ZP-US-1549 01/2025 ©Lilly USA, LCC. 2025. All rights reserved. Zepbound^® is a registered trademark and boundfor^™ is a trademark owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.

5:12-5:14
[Animated Lilly Medicine logo appears on screen]
CAPTION: Lilly A MEDICINE COMPANY

5:14-6:06
[Animated data and safety claims appear on screen]
CAPTION: INDICATIONS AND SAFETY SUMMARY WITH WARNINGS
once weekly zepbound^® (tirzepatide) injection 0.5 mL 2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg
NARRATOR: Indications and safety summary with warnings. Zepbound^® is an injectable prescription medicine that may help adults with:

obesity, or some adults with overweight who also have weight-related medical problems to lose excess body weight and keep the weight off.

moderate-to-severe obstructive sleep apnea (OSA) and obesity to improve their OSA.

It should be used with a reduced-calorie diet and increased physical activity. Zepbound contains tirzepatide and should not be used with other tirzepatide-containing products or any GLP-1 receptor agonist medicines. It is not known if Zepbound is safe and effective for use in children.

6:06-7:24
CAPTION: INDICATIONS AND SAFETY SUMMARY WITH WARNINGS
once weekly zepbound^® (tirzepatide) injection 0.5 mL 2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg
NARRATOR: Warnings. Zepbound may cause tumors in the thyroid, including thyroid cancer. Watch for possible symptoms, such as a lump or swelling in the neck, hoarseness, trouble swallowing, or shortness of breath. If you have any of these symptoms, tell your healthcare provider. Do not use Zepbound if you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC). Do not use Zepbound if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Do not use Zepbound if you have had a serious allergic reaction to tirzepatide or any of the ingredients in Zepbound. Zepbound may cause serious side effects, including severe stomach problems. Stomach problems, sometimes severe, have been reported in people who use Zepbound. Tell your healthcare provider if you have stomach problems that are severe or will not go away. Kidney problems, kidney failure, diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration), which may cause kidney problems. It is important for you to drink fluids to help reduce your chance of dehydration.

7:24-9:00
CAPTION: INDICATIONS AND SAFETY SUMMARY WITH WARNINGS
once weekly zepbound^® (tirzepatide) injection 0.5 mL 2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg
NARRATOR: Gallbladder problems. Gallbladder problems have happened in some people who use Zepbound. Tell your healthcare provider right away if you get symptoms of gallbladder problems, which may include pain in your upper stomach, abdomen, fever, yellowing of skin or eyes, jaundice, or clay-colored stools. Inflammation of the pancreas (pancreatitis). Stop using Zepbound and call your healthcare provider right away. If you have severe pain in your stomach area, abdomen, that will not go away with or without vomiting, you may feel the pain from your abdomen to your back. Serious allergic reactions. Stop using Zepbound and get medical help right away if you have any symptoms of a serious allergic reaction, including swelling of your face, lips, tongue, or throat, problems breathing or swallowing, severe rash or itching, fainting or feeling dizzy, or very rapid heartbeat. Low blood sugar (hypoglycemia). Your risk for getting low blood sugar may be higher if you use Zepbound with medicines that can cause low blood sugar, such as a sulfonylurea or insulin. Signs and symptoms of low blood sugar may include dizziness or lightheadedness, sweating, confusion or drowsiness, headache, blurred vision, slurred speech, shakiness, fast heartbeat, anxiety, irritability, mood changes, hunger, weakness or feeling jittery.

9:00-9:55
CAPTION: INDICATIONS AND SAFETY SUMMARY WITH WARNINGS
once weekly zepbound^® (tirzepatide) injection 0.5 mL 2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg
NARRATOR: Changes in vision in patients with type two diabetes. Tell your healthcare provider if you have changes in vision during treatment with Zepbound. Depression or thoughts of suicide. You should pay attention to changes in your mood, behaviors, feelings, or thoughts. Call your healthcare provider right away if you have any mental changes that are new, worse, or worry you.

Food or liquid getting into the lungs during surgery or other procedures that use anesthesia or deep sleepiness (deep sedation). Zepbound may increase the chance of food getting into your lungs during surgery or other procedures. Tell all your healthcare providers that you are taking Zepbound before you are scheduled to have surgery or other procedures.

Common side effects. The most common side effects of Zepbound include nausea, diarrhea, vomiting, constipation, stomach (abdominal) pain, indigestion, injection site reactions, feeling tired, allergic reactions, belching, hair loss, and heartburn. These are not all the possible side effects of Zepbound. Talk to your healthcare providor about any side effect that bothers you or doesn't go away.

9:55-10:59
CAPTION: INDICATIONS AND SAFETY SUMMARY WITH WARNINGS
once weekly zepbound^® (tirzepatide) injection 0.5 mL 2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg
NARRATOR: Tell your doctor if you have any side effects. You can report side effects at 1-800-FDA-1088 or www.fda.gov/medwatch. Before using Zepbound. Your healthcare provider should show you how to use Zepbound before you use it for the first time. Tell your healthcare provider if you are taking medicines to treat diabetes, including an insulin or sulfonylurea which could increase your risk of low blood sugar. Talk to your healthcare provider about low blood sugar levels and how to manage them. If you take birth control pills by mouth, talk to your healthcare provider before you use Zepbound. Birth control pills may not work as well while using Zepbound. Your healthcare provider may recommend another type of birth control for four weeks after you start Zepbound and for 4 weeks after each increase in your dose of Zepbound.

10:59-11:50
CAPTION: INDICATIONS AND SAFETY SUMMARY WITH WARNINGS
once weekly zepbound^® (tirzepatide) injection 0.5 mL 2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg
NARRATOR: Review these questions with your healthcare provider. Do you have other medical conditions, including problems with your pancreas or kidneys, or severe problems with your stomach, such as slowed emptying of your stomach (gastroparesis) or problems digesting food? Do you take diabetes medicines such as insulin or sulfonylureas? Do you have a history of diabetic retinopathy? Are you scheduled to have surgery or other procedures that use anesthesia or deep sleepiness (deep sedation)? Do you take any other prescription medicines or over the counter drugs, vitamins, or herbal supplements? Are you pregnant, plan to become pregnant, breastfeeding, or plan to breastfeed? Zepbound may harm your unborn baby. Tell your healthcare provider if you become pregnant while using Zepbound. It is not known if Zepbound passes into your breast milk. You should talk with your healthcare provider about the best way to feed your baby while using Zepbound.

11:50-13:06
CAPTION: INDICATIONS AND SAFETY SUMMARY WITH WARNINGS
once weekly zepbound^® (tirzepatide) injection 0.5 mL 2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg
NARRATOR: Pregnancy Exposure Registry. There will be a pregnancy exposure registry for women who have taken Zepbound during pregnancy. The purpose of this registry is to collect information about the health of you and your baby. Talk to your healthcare provider about how you can take part in this registry. Or you may contact Lilly at 1-800-LillyRX (1-800-545-5979). How to take. Read the Instructions for Use that come with Zepbound. Use Zepbound exactly as your healthcare provider says. Use Zepbound with a reduced-calorie diet and increased physical activity. Zepbound is injected under the skin (subcutaneously) of your stomach, abdomen, thigh, or upper arm. Use Zepbound 1 time each week at any time of the day. Change (rotate) your injection site with each weekly injection. Do not use the same site for each injection. If you take too much Zepbound, call your healthcare provider, seek medical advice promptly, or contact a poison center expert right away at 1-800-222-1222.

Zepbound injection is approved as a 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, or 15 mg per 0.5 mL in single-dose pen or single-dose vial.

13:06-14:00
CAPTION: INDICATIONS AND SAFETY SUMMARY WITH WARNINGS
once weekly zepbound^® (tirzepatide) injection 0.5 mL 2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg
NARRATOR: Learn more. Zepbound is a prescription medicine. For more information, call 1-800-LillyRX (1-800-545-5979) or go to www.Zepbound.lilly.com. This summary provides basic information about Zepbound, but does not include all information known about this medicine. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your healthcare provider. Be sure to talk to your healthcare provider about Zepbound and how to take it. Your healthcare provider is the best person to help you decide if Zepbound is right for you.
CAPTION: INDICATIONS AND SAFETY SUMMARY WITH WARNINGS
once weekly zepbound^® (tirzepatide) injection 0.5 mL 2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg
CAPTION: ZP CON BS 20DEC2024. Zepbound^® and its delivery device base are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.

14:00-14:03
[Animated Zepbound logo appears on screen]
CAPTION: once weekly zepbound^® (tirzepatide) injection 0.5 mL 2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg
Visit www.zepbound.com or call 1-800-LillyRX
A Lilly Medicine
PP-ZP-US-1549 01/2025 ©Lilly USA, LCC. 2025. All rights reserved. Zepbound^® is a registered trademark and boundfor^™ is a trademark owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.

14:03-14:05
[Animated Lilly Medicine logo appears on screen]
CAPTION: Lilly A MEDICINE COMPANY

Meet TimBo

As a stylist, TimBo prides himself on pouring into others, helping his clients look and feel good every day. But this is the year of TimBo. Find out why.

00:00-00:05
[Animated intro sequence appears]
CAPTION: Please see the safety information before Noelle’s story.

00:05-00:09
[Animated intro sequence with Zepbound Logo appears]
CAPTION: once weekly Zepbound^® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5 mg| 15mg
A Lilly Medicine
visit www.zepbound.lilly.com or call 1-800-LillyRX for pricing information

00:09-00:52 [Opening indications appears and remains on-screen until the narrator concludes]
NARRATOR:
Zepbound is an injectable prescription medicine that may help adults with obesity, or some adults with overweight who also have weight-related medical problems, to lose excess body weight and keep the weight off. It may also help adults with moderate-to-severe obstructive sleep apnea (OSA) and obesity to improve their OSA. It should be used with a reduced-calorie diet and increased physical activity.
Zepbound contains tirzepatide and should not be used with other tirzepatide-containing products or any GLP-1 receptor agonist medicines. It is not known if Zepbound is safe and effective for use in children.

00:53-01:34
NARRATOR: Select Safety Information. Tell your healthcare provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In studies with rats, Zepbound and medicines that work like Zepbound caused thyroid tumors, including thyroid cancer. It is not known if Zepbound will cause thyroid tumors, or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people. Do not take Zepbound if you or any of your family have ever had MTC or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).

01:35-01:42
[Ambient music, ocean waves, and seagull sounds play in the background; Noelle standing on beach, looking out at the water]
CAPTION: Noelle was a Zepbound clinical trial participant and was compensated for her time. Individual results may vary. Talk to your doctor to see if Zepbound^® is right for you.
NOELLE: I was stuck for 15 to probably 18 years. I tried multiple trends to lose weight and nothing would work.

01:42—1:48
[Noelle is on screen speaking to the camera]
NOELLE: Up until I was 30, I was pretty athletic, slender, was always out

01:49—1:51
[Noelle and her friends doing Tai Chi on the beach]
NOELLE: with my friends, doing fun things, so I stayed pretty

01:51—1:54
[Noelle doing Tai Chi alone on the beach.]
NOELLE: thin. Well, once I had a baby

01:54—1:58
[Noelle is on screen speaking to camera.]
NOELLE: I was putting on five, 10 pounds a year.

01:58—2:02
[Noelle doing Tai Chi alone on the beach, looking reflective.
NOELLE: It sneaks up on you, you know? And after

02:02—2:06
[Noelle is on screen speaking to camera.]
NOELLE: turning 40, it was impossible for me to lose weight

02:06—2:12
[Noelle and her friends doing Tai Chi on the beach.]
NOELLE: I would start a diet. I’d lose weight, then I’d hit a certain point and

02:12—2:16
[Noelle and her friends doing Tai Chi on the beach.]
NOELLE: it just would stop coming off. And then I finally went to my doctor for

02:16—2:22 [Noelle is on screen talking to camera.] NOELLE: help, they told me I was overweight and that I had high blood pressure.

02:22—2:24
[Noelle is on screen talking to camera.]
NOELLE: For myself,

02:24—2:29
[Pictures of Noelle and her son appear on screen.]
NOELLE: for my son, and for my family – there needed to be a change.

02:29—2:34 [Noelle is on screen talking to camera.]
CAPTION: Individual results may vary. Talk to your doctor to see if Zepbound^® is right for you.
>NOELLE: When taking Zepbound along with diet and exercise,

02:29—2:34
[Noelle is on screen talking to camera.]
CAPTION: Throughout a 17-month clinical trial, people who dieted, exercised,* and took Zepbound sustained weight loss—whether taking the 5-mg, 10-mg, or 15-mg dose.†
SUPER: Zepbound is not for cosmetic weight loss.
Along with a reduced-calorie diet and increased physical activity. Individual results may vary. In studies, average weight loss in adults with or without diabetes was ~15% (34 lbs) on 5 mg, ~13-20% (28- 44 lbs) on 10 mg, and ~15-21% (33-48 lbs) on 15 mg compared to ~3% (7 lbs) on placebo. Avg. baseline weights were ~220-233 Ibs.
NOELLE: I was able to lose significant weight and maintain my weight loss during the trial.

02:40—2:51
[Pictures from Noelle’s weight loss journey appear on screen.]
CAPTION: Throughout a 17-month clinical trial, people who dieted, exercised,* and took Zepbound sustained weight loss—whether taking the 5-mg, 10-mg, or 15-mg dose.
SUPER: Zepbound is not for cosmetic weight loss.
Along with a reduced-calorie diet and increased physical activity. Individual results may vary. In studies, average weight loss in adults with or without diabetes was ~15% (34 lbs) on 5 mg, ~13-20% (28- 44 lbs) on 10 mg, and ~15-21% (33-48 lbs) on 15 mg compared to ~3% (7 lbs) on placebo. Avg. baseline weights were ~220-233 Ibs.
NOELLE: I was a size 22. As I started taking the medication and went down to size 18 and then eventually 16 and 14.

02:51—2:54
[Noelle doing Zumba in a backyard.]
CAPTION: Zepbound is not for cosmetic weight loss.
Along with diet and exercise.
Individual results may vary. In studies, average weight loss in adults with or without diabetes was ~15% (34 lbs) on 5 mg, ~13-20% (28-44 lbs) on 10 mg, and ~15-21% (33-48 lbs) on 15 mg compared to ~3% (7 lbs) on placebo. Avg. baseline weights were ~220-233 Ibs.
NOELLE: When I eventually got down to 12, I was like

02:54—02:57
[Noelle doing Zumba in a backyard.]
CAPTION: Zepbound is not for cosmetic weight loss.
Along with diet and exercise.
Individual results may vary. In studies, average weight loss in adults with or without diabetes was ~15% (34 lbs) on 5 mg, ~13-20% (28-44 lbs) on 10 mg, and ~15-21% (33-48 lbs) on 15 mg compared to ~3% (7 lbs) on placebo. Avg. baseline weights were ~220-233 Ibs.
NOELLE: this is the most exciting thing ever.

02:57—03:00
[Noelle doing Zumba in a backyard.]
CAPTION: Zepbound is not for cosmetic weight loss.
Along with diet and exercise.
Individual results may vary. In studies, average weight loss in adults with or without diabetes was ~15% (34 lbs) on 5 mg, ~13-20% (28-44 lbs) on 10 mg, and ~15-21% (33-48 lbs) on 15 mg compared to ~3% (7 lbs) on placebo. Avg. baseline weights were ~220-233 Ibs.
NOELLE: I feel seen.

03:00—03:03
[Noelle doing Zumba in a backyard.]
CAPTION: Zepbound is not for cosmetic weight loss.
Along with diet and exercise.
Individual results may vary. In studies, average weight loss in adults with or without diabetes was ~15% (34 lbs) on 5 mg, ~13-20% (28-44 lbs) on 10 mg, and ~15-21% (33-48 lbs) on 15 mg compared to ~3% (7 lbs) on placebo. Avg. baseline weights were ~220-233 Ibs.
NOELLE: I love dancing, so you know, I am too old to go to the

03:03—03:08
[Noelle doing Zumba in a backyard.]
CAPTION: Zepbound is not for cosmetic weight loss.
Along with diet and exercise.
Individual results may vary. In studies, average weight loss in adults with or without diabetes was ~15% (34 lbs) on 5 mg, ~13-20% (28-44 lbs) on 10 mg, and ~15-21% (33-48 lbs) on 15 mg compared to ~3% (7 lbs) on placebo. Avg. baseline weights were ~220-233 Ibs.
NOELLE: nightclubs. (laughs) So, my nightclub is Zumba.

03:08—03:10
[Ambient sounds of the ocean, Noelle and her friends walking arm in arm along the beach.]
CAPTION: Zepbound is not for cosmetic weight loss.
Along with diet and exercise.
Individual results may vary. In studies, average weight loss in adults with or without diabetes was ~15% (34 lbs) on 5 mg, ~13-20% (28-44 lbs) on 10 mg, and ~15-21% (33-48 lbs) on 15 mg compared to ~3% (7 lbs) on placebo. Avg. baseline weights were ~220-233 Ibs.
NOELLE: I love enjoying

03:10—03:12
[Ambient sounds of Noelle and her friends talking, Noelle and her friends are enjoying a picnic on the beach.]
CAPTION: Zepbound is not for cosmetic weight loss.
Along with diet and exercise.
Individual results may vary. In studies, average weight loss in adults with or without diabetes was ~15% (34 lbs) on 5 mg, ~13-20% (28-44 lbs) on 10 mg, and ~15-21% (33-48 lbs) on 15 mg compared to ~3% (7 lbs) on placebo. Avg. baseline weights were ~220-233 Ibs.
NOELLE: the sun

03:12—03:20
[Ambient sounds of Noelle and her friends talking, Noelle and her friends are enjoying a picnic on the beach.]
NOELLE: and having great food with great friends. And the food is actually good for you.

03:20—03:28
[Noelle is on screen talking to camera.]
NOELLE: All these times when I was trying to lose weight and couldn’t, I just felt like well my body

03:28—03:31
[Noelle holds a coffee mug and slowly lifts it up.]
NOELLE: likes the weight, and there’s nothing I can do.

03:31—03:37
[Noelle drinks from a coffee mug in a backyard space.]
NOELLE: And what was surprising with Zepbound was that my body did wanna lose weight. I would eat half

03:37—03:38
[Noelle is on screen talking to camera.]
NOELLE: of what I used to eat

03:38—03:41
[Noelle is in backyard, holding a coffee mug looking out at the sky.]
NOELLE: and feel satisfied.

03:41—03:43
[Noelle is doing Tai Chi alone on the beach.]
NOELLE: I feel the best

03:43—03:45
[Noelle is doing Zumba in the backyard.]
NOELLE: part of this

03:45—03:46
[Noelle looks out up and around on the beach.]
NOELLE: journey is that

03:46—03:47
[Noelle is hiking alone on a trail, smiling.]
NOELLE: I am

03:47—03:49
[Noelle is on screen talking to camera.]
NOELLE: a role model to my child.

03:49—03:52
Noelle and her son are hiking and talking.]
NOELLE: You’re always looking for a new goal to hit

03:52—03:54
[Noelle and her son are hiking and talking.]
NOELLE: knock that off my bucket list, you know?

03:54—03:59
[Noelle and her son look at each other during a pause on the hike.]
NOELLE: I think he’s very proud of me. I think he looks at me as inspiration and he knows I’m

03:59—04:02
[Noelle and her son pause to take a selfie on their hike.]
NOELLE: doing it for him too.

04:02—04:04
[We see the selfie Noelle took of her and her son.]
Noelle: I’m proud of myself right now and I

04:04—04:06
[Noelle and her son are talking and hiking.]
NOELLE: look back at my past self and say, “you go

04:06—04:13
[Noelle is standing on the beach and turns to look at the camera.]
NOELLE: girl.” I’m bound for new ways to celebrate the love I have for myself.

04:13-04:15
[Animated Zepbound logo appears on screen]
CAPTION: once weekly Zepbound^® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5 mg| 15mg
A Lilly Medicine visit www.zepbound.lilly.com or call 1-800-LillyRX for pricing information

04:15-04:17
[Animated Lilly Medicine logo appears on screen]
CAPTION: Lilly
A MEDICINE COMPANY

04:17-05:09
[Animated data and safety claims appear on screen]
CAPTION: INDICATIONS AND SAFETY SUMMARY WITH WARNINGS
once weekly Zepbound^® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5 mg| 15mg
NARRATOR: Indications and Safety Summary with Warnings. Zepbound^® is an injectable prescription medicine that may help adults with:

obesity, or some adults with overweight who also have weight-related medical problems to lose excess body weight and keep the weight off.

moderate-to-severe obstructive sleep apnea (OSA) and obesity to improve their OSA.

It should be used with a reduced-calorie diet and increased physical activity. Zepbound contains tirzepatide and should not be used with other tirzepatide-containing products or any GLP-1 receptor agonist medicines. It is not known if Zepbound is safe and effective for use in children.

05:09-06:26
CAPTION: INDICATIONS AND SAFETY SUMMARY WITH WARNINGS
once weekly Zepbound^® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5 mg| 15mg
NARRATOR: Warnings. Zepbound may cause tumors in the thyroid, including thyroid cancer. Watch for possible symptoms, such as a lump or swelling in the neck, hoarseness, trouble swallowing, or shortness of breath. If you have any of these symptoms, tell your healthcare provider. Do not use Zepbound if you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC). Do not use Zepbound if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Do not use Zepbound if you have had a serious allergic reaction to tirzepatide or any of the ingredients in Zepbound. Zepbound may cause serious side effects, including, severe stomach problems. Stomach problems, sometimes severe, have been reported in people who use Zepbound. Tell your healthcare provider if you have stomach problems that are severe or will not go away. Kidney problems (kidney failure). Diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration), which may cause kidney problems. It is important for you to drink fluids to help reduce your chance of dehydration.

06:26-08:03
CAPTION: INDICATIONS AND SAFETY SUMMARY WITH WARNINGS
once weekly Zepbound^® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5 mg| 15mg
NARRATOR: Gallbladder problems. Gallbladder problems have happened in some people who use Zepbound. Tell your healthcare provider right away if you get symptoms of gallbladder problems, which may include pain in your upper stomach (abdomen), fever, yellowing of skin or eyes (jaundice), or clay-colored stools. Inflammation of the pancreas (pancreatitis). Stop using Zepbound and call your healthcare provider right away if you have severe pain in your stomach area (abdomen) that will not go away, with or without vomiting. You may feel the pain from your abdomen to your back. Serious allergic reactions. Stop using Zepbound and get medical help right away if you have any symptoms of a serious allergic reaction, including swelling of your face, lips, tongue or throat, problems breathing or swallowing, severe rash or itching, fainting or feeling dizzy, or very rapid heartbeat. Low blood sugar (hypoglycemia). Your risk for getting low blood sugar may be higher if you use Zepbound with medicines that can cause low blood sugar, such as a sulfonylurea or insulin. Signs and symptoms of low blood sugar may include dizziness or light-headedness, sweating, confusion or drowsiness, headache, blurred vision, slurred speech, shakiness, fast heartbeat, anxiety, irritability, mood changes, hunger, weakness or feeling jittery.

08:03-08:57
CAPTION: INDICATIONS AND SAFETY SUMMARY WITH WARNINGS
once weekly Zepbound^® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5 mg| 15mg
NARRATOR: Changes in vision in patients with type 2 diabetes. Tell your healthcare provider if you have changes in vision during treatment with Zepbound. Depression or thoughts of suicide. You should pay attention to changes in your mood, behaviors, feelings or thoughts. Call your healthcare provider right away if you have any mental changes that are new, worse, or worry you. Food or liquid getting into the lungs during surgery or other procedures that use anesthesia or deep sleepiness (deep sedation). Zepbound may increase the chance of food getting into your lungs during surgery or other procedures. Tell all your healthcare providers that you are taking Zepbound before you are scheduled to have surgery or other procedures.

Common side effects. The most common side effects of Zepbound include nausea, diarrhea, vomiting, constipation, stomach (abdominal) pain, indigestion, injection site reactions, feeling tired, allergic reactions, belching, hair loss, and heartburn. These are not all the possible side effects of Zepbound. Talk to your healthcare provider about any side effect that bothers you or doesn’t go away.

08:57-10:01
CAPTION: INDICATIONS AND SAFETY SUMMARY WITH WARNINGS
once weekly Zepbound^® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5 mg| 15mg
NARRATOR: Tell your healthcare provider if you have any side effects. You can report side effects at 1-800-FDA-1088 or www.fda.gov/medwatch. Before using Zepbound. Your healthcare provider should show you how to use Zepbound before you use it for the first time. Tell your healthcare provider if you are taking medicines to treat diabetes including an insulin or sulfonylurea which could increase your risk of low blood sugar. Talk to your healthcare provider about low blood sugar levels and how to manage them. If you take birth control pills by mouth, talk to your healthcare provider before you use Zepbound. Birth control pills may not work as well while using Zepbound. Your healthcare provider may recommend another type of birth control for 4 weeks after you start Zepbound and for 4 weeks after each increase in your dose of Zepbound.

10:01-10:54
CAPTION: INDICATIONS AND SAFETY SUMMARY WITH WARNINGS
once weekly Zepbound^® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5 mg| 15mg
NARRATOR: Review these questions with your healthcare provider. Do you have other medical conditions, including problems with your pancreas or kidneys, or severe problems with your stomach, such as slowed emptying of your stomach (gastroparesis) or problems digesting food? Do you take diabetes medicines, such as insulin or sulfonylureas? Do you have a history of diabetic retinopathy? Do you take any other prescription medicines or over-the-counter drugs, vitamins, or herbal supplements? Are you pregnant, plan to become pregnant, breastfeeding, or plan to breastfeed? Zepbound may harm your unborn baby. Tell your healthcare provider if you become pregnant while using Zepbound. It is not known if Zepbound passes into your breast milk. You should talk with your healthcare provider about the best way to feed your baby while using Zepbound.

10:54-12:08
CAPTION: INDICATIONS AND SAFETY SUMMARY WITH WARNINGS
once weekly Zepbound^® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5 mg| 15mg
NARRATOR: Pregnancy Exposure Registry. There will be a pregnancy exposure registry for women who have taken Zepbound during pregnancy. The purpose of this registry is to collect information about the health of you and your baby. Talk to your healthcare provider about how you can take part in this registry, or you may contact Lilly at 1-800-LillyRx (1-800-545-5979). How to take. Read the Instructions for Use that come with Zepbound. Use Zepbound exactly as your healthcare provider says. Use Zepbound with a reduced-calorie diet and increased physical activity. Zepbound is injected under the skin (subcutaneously) of your stomach (abdomen), thigh, or upper arm. Use Zepbound 1 time each week, at any time of the day. Change (rotate) your injection site with each weekly injection. Do not use the same site for each injection. If you take too much Zepbound, call your healthcare provider, seek medical advice promptly, or contact a Poison Center expert right away at 1-800-222-1222.
Zepbound injection is approved as a 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, or 15 mg per 0.5 mL in single-dose pen or single-dose vial.

12:08-12:54
CAPTION: INDICATIONS AND SAFETY SUMMARY WITH WARNINGS
once weekly Zepbound^® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5 mg| 15mg
NARRATOR: Learn more. Zepbound is a prescription medicine. For more information, call 1-800-LillyRx (1-800-545-5979) [or go to www.zepbound.lilly.com]. This summary provides basic information about Zepbound but does not include all information known about this medicine. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your healthcare provider. Be sure to talk to your healthcare provider about Zepbound and how to take it. Your healthcare provider is the best person to help you decide if Zepbound is right for you.

12:54 –12:58
CAPTION: INDICATIONS AND SAFETY SUMMARY WITH WARNINGS
once weekly Zepbound^® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5 mg| 15mg
CAPTION: ZP CON BS20DEC2024. Zepbound^® and its delivery device base are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.

12:59-13:00
[Animated Zepbound logo appears on screen]
CAPTION: once weekly Zepbound^® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5 mg| 15mg
A Lilly Medicine
visit www.zepbound.lilly.com or call 1-800-LillyRX for pricing information

13:00-13:02
[Animated Lilly Medicine logo appears on screen]
CAPTION: Lilly
A MEDICINE COMPANY

Meet Noelle

Noelle loves being active and focuses on finding ways to move her body every day. Hear more on why Noelle wanted to share her story with others.

00:00-00:03
[Animated intro sequence appears]
CAPTION Please see the safety information before Heather's story.

00:03-00:48
[Animated intro sequence with Zepbound Logo appears]
CAPTION once weekly zepbound^® (tirzepatide) injection 0.5 mL 2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg
[Opening indications appears and remains on-screen until the narrator concludes]
Zepbound is an injectable prescription medicine that may help adults with obesity, or some adults with overweight who also have weight-related medical problems, to lose excess body weight and keep the weight off. It may also help adults with moderate-to-severe obstructive sleep apnea (OSA) and obesity to improve their OSA. It should be used with a reduced-calorie diet and increased physical activity.

Zepbound contains tirzepatide and should not be used with other tirzepatide-containing products or any GLP-1 receptor agonist medicines. It is not known if Zepbound is safe and effective for use in children.

00:48-1:28
NARRATOR: Select Safety Information. Tell your healthcare provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In studies with rats, Zepbound and medicines that work like Zepbound caused thyroid tumors, including thyroid cancer. It is not known if Zepbound will cause thyroid tumors, or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people. Do not take Zepbound if you or any of your family have ever had MTC or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).

NARRATOR: See Indication and Safety Summary with Warnings at the end of this video.

CAPTION See Indications and Safety Summary with Warnings at the end of this video.

1:28-1:34
[Opening scene pans to overhead drone shot of amusement park Ferris Wheel; Heather walking in the amusement park with her kids; Heather speaks to camera at the park]
CAPTION Heather is a Zepbound clinical trial participant and was compensated for her time. Individual results may vary. Talk to your doctor to see if Zepbound is right for you.
HEATHER: Being in the park here today means the world.

1:34-1:39
[Heather laughing on the Ferris Wheel with son; pan to interview with Heather and back to the park with her kids on a ride]
HEATHER: I've been wanting to take my kids to an amusement park for as long as I can remember.

1:39-1:49
[Black and white glimpses of Heather reflecting and walking at the amusement park]
HEATHER: I had a lot of things holding me back. I was concerned I couldn't handle the heat. I didn't want to draw attention to myself when I'd have to continue to stop.

1:49-1:55
[Black and white shots of amusement park rides continue]
HEATHER: I worried I wouldn't fit in the seats. I wouldn't be able to secure the belts and the safety devices.

1:55-2:02
[Heather sitting outside with her son]
HEATHER: Michael, my oldest, went to an amusement park for the first time without me.

2:02-2:06
[Heather sitting at home speaking to camera]
HEATHER: He went on that roller coaster. That was sad for me.

2:06-2:16
[Close up of Heather watching old photos on a projector; old photos from projector start appearing on screen]
HEATHER: I've been trying to lose weight on and off all my life, but really in the last 10 years it’s been very challenging. My daughter's never known me, not overweight.

2:16-2:21
[Heather watching old photos; before photos of Heather when she was a kid appears on screen]
HEATHER: When I was a kid, I was always the chunkier one. I'd get made fun of.

2:21-2:30
[Heather at the pool]
HEATHER: Pools were not my friend either. We'd like swim under water and everybody would have their legs spread and you'd swim through 'em like a tunnel. Well, when it came to my turn...

2:30-2:33
[Heather from behind looking out at the pool]
HEATHER:...they'd usually swim away.

2:33-2:35
[Heather sitting at home speaking to camera]
HEATHER: My weight loss journey has been a roller coaster.

2:35-2:39
[Close up of Heather’s face watching old photos]
HEATHER: I had tried different diets and exercises and nothing was working.

2:39-2:44
[Heather in the kitchen; Quick shots appear on screen of Heather closing refrigerator door, opening snack, and pulling plates out of cabinet]
HEATHER: My relationship with food was very loud.

2:44-2:47
[Heather sits on couch and stands up]
HEATHER: Even when I wasn't hungry.

2:47-2:54
[Overhead shot of neighborhood pans to Heather outside gardening]
HEATHER: I advocated for myself and I was able to assemble a team that heard me...

2:54-2:58
[Close up of Heather gardening. Pans to interview of her at home]
HEATHER: and was willing to advocate for changes that I was needing to make.

2:58-3:02
[Heather at home speaking to camera then pans to her gardening]
HEATHER: My doctors put in a recommendation for Zepbound for me.

3:02-3:06
[Heather outside with her daughter; Her daughter rides her bike as Heather watches]
CAPTION Individual results may vary. Talk to your doctor to see if Zepbound^® is right for you.
HEATHER: I am so happy that they recommended Zepbound.

3:06-3:12
[Heather playing outside and sitting at home]
CAPTION Throughout a 17-month clinical trial, people who dieted, exercised,^* and took Zepbound sustained weight loss—whether taking the 5-mg, 10-mg, or 15-mg dose.^†
Zepbound is not for cosmetic weight loss.
^*Along with reduced-calorie diet and increased physical activity.

^†Individual results may vary. In studies, average weight loss in adults with or without diabetes was ~15% (34 lbs) on 5 mg, ~13-20% (28-44 lbs) on 10 mg, and ~15-21% (33-48 lbs) on 15 mg compared to ~3% (7 lbs) on placebo. Avg. baseline weights were ~220-233 lbs.
HEATHER: With Zepbound along with diet and exercise, I'm losing weight and keeping it off.

3:12-3:19
[Heather outside grilling]
CAPTION Zepbound is not for cosmetic weight loss.
^*Along with reduced-calorie diet and increased physical activity.
^†Individual results may vary. In studies, average weight loss in adults with or without diabetes was ~15% (34 lbs) on 5 mg, ~13-20% (28-44 lbs) on 10 mg, and ~15-21% (33-48 lbs) on 15 mg compared to ~3% (7 lbs) on placebo. Avg. baseline weights were ~220-233 lbs.
HEATHER: Grilling is one of my favorite ways to cook supper. Desire for food all the time pretty much stopped...

3:19-3:27
[Heather continues grilling; pans to Heather sitting at home]
HEATHER: ...after Zepbound. I've gone down several sizes and I've been able to clean out my closet and donate the clothes that don't fit me anymore.

3:27-3:33
[Heather playing with her kids outside]
HEATHER: I'm gonna dust off the bike and ride with my daughter. I'm gonna play catch with my son.

3:33-3:38
[Heather playing at the pool with her daughter; her daughter splashes in pool; video pans to a close up of Heather smiling outside]
HEATHER: We're gonna do the activities that they want to do while they still want to do them with me.

3:38-3:42
[Overhead shot of amusement park]

3:42-3:45
[Heather talking to camera outside at the amusement park]
HEATHER: I've always had a dream to take my kids to the amusement park

3:45-3:50
[Heather and kids walking toward a ride]
HEATHER: But we are here today and it's amazing.

3:50-4:00
[Heather watching rides and interacting with kids at the park]
This is an important summer for me. My oldest is gonna be a senior and moving on soon, so having these memories with him now, it means the world.

4:00-4:06
[Heather and her daughter strap in for a roller coaster ride]
HEATHER: Like a glove.
DAUGHTER: Yeah, <laughs>.

4:06-4:12
[Heather and her kids ride a roller coaster; pans to full shot of the ride]
HEATHER: In the past, my weight loss journey has been a roller coaster. It's been frustrating. It's been bumpy.

4:12-4:16
[Heather on rides with kids]
CAPTION ^*Along with diet and exercise. Individual results may vary.
HEATHER: With Zepbound, I got off that roller coaster.

4:16-4:23
[Heather and kids walk toward camera; kids run off into distance; Heather is left behind, smiling at camera]
[Animated boundfor logo appears on screen]
HEATHER: This is just the beginning of my journey. I'm bound for making memories with my family.

4:23-4:27
[Animated Zepbound logo appears on screen]
CAPTION once weekly zepbound^® (tirzepatide) injection 0.5 mL 2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg
Visit www.zepbound.lilly.com or call 1-800-LillyRX
A Lilly Medicine
PP-ZP-US-0743 10/2024 © Lilly USA, LLC. 2024. All rights reserved. Zepbound^® is a registered trademark and boundfor™ is a trademark owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.

4:27-4:29
[Animated Lilly Medicine logo appears on screen]
CAPTION Lilly A MEDICINE COMPANY

4:29-5:22
[Animated data and safety claims appear on screen]
CAPTION INDICATIONS AND SAFETY SUMMARY WITH WARNINGS
once weekly zepbound^® (tirzepatide) injection 0.5 mL 2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg
NARRATOR: Indications and safety summary with warnings. Zepbound^® is an injectable prescription medicine that may help adults with:

obesity, or some adults with overweight who also have weight-related medical problems to lose excess body weight and keep the weight off.

moderate-to-severe obstructive sleep apnea (OSA) and obesity to improve their OSA.

It should be used with a reduced-calorie diet and increased physical activity. Zepbound contains tirzepatide and should not be used with other tirzepatide-containing products or any GLP-1 receptor agonist medicines. It is not known if Zepbound is safe and effective for use in children.

5:22-6:36
CAPTION INDICATIONS AND SAFETY SUMMARY WITH WARNINGS
once weekly zepbound^® (tirzepatide) injection 0.5 mL 2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg
NARRATOR: Warnings. Zepbound may cause tumors in the thyroid, including thyroid cancer. Watch for possible symptoms, such as a lump or swelling in the neck, hoarseness, trouble swallowing, or shortness of breath. If you have any of these symptoms, tell your healthcare provider. Do not use Zepbound if you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC). Do not use Zepbound if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Do not use Zepbound if you have had a serious allergic reaction to tirzepatide or any of the ingredients in Zepbound. Zepbound may cause serious side effects, including severe stomach problems. Stomach problems, sometimes severe, have been reported in people who use Zepbound. Tell your healthcare provider if you have stomach problems that are severe or will not go away. Kidney problems, kidney failure, diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration), which may cause kidney problems. It is important for you to drink fluids to help reduce your chance of dehydration.

6:36-8:16
CAPTION INDICATIONS AND SAFETY SUMMARY WITH WARNINGS
once weekly zepbound^® (tirzepatide) injection 0.5 mL 2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg
NARRATOR: Gallbladder problems. Gallbladder problems have happened in some people who use Zepbound. Tell your healthcare provider right away if you get symptoms of gallbladder problems, which may include pain in your upper stomach, abdomen, fever, yellowing of skin or eyes, jaundice, or clay-colored stools. Inflammation of the pancreas (pancreatitis). Stop using Zepbound and call your healthcare provider right away. If you have severe pain in your stomach area, abdomen, that will not go away with or without vomiting, you may feel the pain from your abdomen to your back. Serious allergic reactions. Stop using Zepbound and get medical help right away if you have any symptoms of a serious allergic reaction, including swelling of your face, lips, tongue, or throat, problems breathing or swallowing, severe rash or itching, fainting or feeling dizzy, or very rapid heartbeat. Low blood sugar (hypoglycemia). Your risk for getting low blood sugar may be higher if you use Zepbound with medicines that can cause low blood sugar, such as a sulfonylurea or insulin. Signs and symptoms of low blood sugar may include dizziness or lightheadedness, sweating, confusion or drowsiness, headache, blurred vision, slurred speech, shakiness, fast heartbeat, anxiety, irritability, mood changes, hunger, weakness or feeling jittery.

8:16-9:10
CAPTION INDICATIONS AND SAFETY SUMMARY WITH WARNINGS
once weekly zepbound^® (tirzepatide) injection 0.5 mL 2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg
NARRATOR: Changes in vision in patients with type two diabetes. Tell your healthcare provider if you have changes in vision during treatment with Zepbound. Depression or thoughts of suicide. You should pay attention to changes in your mood, behaviors, feelings, or thoughts. Call your healthcare provider right away if you have any mental changes that are new, worse, or worry you.

Food or liquid getting into the lungs during surgery or other procedures that use anesthesia or deep sleepiness (deep sedation). Zepbound may increase the chance of food getting into your lungs during surgery or other procedures. Tell all your healthcare providers that you are taking Zepbound before you are scheduled to have surgery or other procedures.

Common side effects. The most common side effects of Zepbound include nausea, diarrhea, vomiting, constipation, stomach (abdominal) pain, indigestion, injection site reactions, feeling tired, allergic reactions, belching, hair loss, and heartburn. These are not all the possible side effects of Zepbound. Talk to your healthcare provider about any side effect that bothers you or doesn't go away.

9:10-10:15
CAPTION INDICATIONS AND SAFETY SUMMARY WITH WARNINGS
once weekly zepbound^® (tirzepatide) injection 0.5 mL 2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg
NARRATOR: Tell your healthcare provider if you have any side effects. You can report side effects at 1-800-FDA-1088 or www.fda.gov/medwatch. Before using Zepbound. Your healthcare provider should show you how to use Zepbound before you use it for the first time. Tell your healthcare provider if you are taking medicines to treat diabetes, including an insulin or sulfonylurea which could increase your risk of low blood sugar. Talk to your healthcare provider about low blood sugar levels and how to manage them. If you take birth control pills by mouth, talk to your healthcare provider before you use Zepbound. Birth control pills may not work as well while using Zepbound. Your healthcare provider may recommend another type of birth control for four weeks after you start Zepbound and for 4 weeks after each increase in your dose of Zepbound.

10:15-11:07 CAPTION INDICATIONS AND SAFETY SUMMARY WITH WARNINGS
once weekly zepbound^®(tirzepatide) injection 0.5 mL 2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg
NARRATOR: Review these questions with your healthcare provider. Do you have other medical conditions, including problems with your pancreas or kidneys, or severe problems with your stomach, such as slowed emptying of your stomach (gastroparesis) or problems digesting food? Do you take diabetes medicines such as insulin or sulfonylureas? Do you have a history of diabetic retinopathy? Do you take any other prescription medicines or over the counter drugs, vitamins, or herbal supplements? Are you pregnant, plan to become pregnant, breastfeeding, or plan to breastfeed? Zepbound may harm your unborn baby. Tell your healthcare provider if you become pregnant while using Zepbound. It is not known if Zepbound passes into your breast milk. You should talk with your healthcare provider about the best way to feed your baby while using Zepbound.

11:07-12:21
CAPTION INDICATIONS AND SAFETY SUMMARY WITH WARNINGS
once weekly zepbound^® (tirzepatide) injection 0.5 mL 2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg
NARRATOR: Pregnancy Exposure Registry. There will be a pregnancy exposure registry for women who have taken Zepbound during pregnancy. The purpose of this registry is to collect information about the health of you and your baby. Talk to your healthcare provider about how you can take part in this registry. Or you may contact Lily at 1-800-LillyRX (1-800-545-5979). How to take. Read the Instructions for Use that come with Zepbound. Use Zepbound exactly as your healthcare provider says. Use Zepbound with a reduced-calorie diet and increased physical activity. Zepbound is injected under the skin (subcutaneously) of your stomach, abdomen, thigh, or upper arm. Use Zepbound 1 time each week at any time of the day. Change (rotate) your injection site with each weekly injection. Do not use the same site for each injection. If you take too much Zepbound, call your healthcare provider, seek medical advice promptly, or contact a poison center expert right away at 1-800-222-1222.

Zepbound injection is approved as a 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, or 15 mg per 0.5 mL in single-dose pen or single-dose vial.

12:21-13:16
CAPTION INDICATIONS AND SAFETY SUMMARY WITH WARNINGS
once weekly zepbound^® (tirzepatide) injection 0.5 mL 2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg
NARRATOR: Learn more. Zepbound is a prescription medicine. For more information, call 1-800-LillyRX (1-800-545-5979) [or go to www.Zepbound.lilly.com]. This summary provides basic information about Zepbound, but does not include all information known about this medicine. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your healthcare provider. Be sure to talk to your healthcare provider about Zepbound and how to take it. Your healthcare provider is the best person to help you decide if Zepbound is right for you.
CAPTION INDICATIONS AND SAFETY SUMMARY WITH WARNINGS
once weekly zepbound^® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5 mg | 15mg
CAPTION ZP CON BS20DEC2024. Zepbound^® and its delivery device base are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.

13:16-13:18
[Animated Zepbound logo appears on screen]
CAPTION once weekly zepbound^® (tirzepatide) injection 0.5 mL 2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg
Visit www.zepbound.com or call 1-800-LillyRX
PP-ZP-US-1548 01/2025 ©Lilly USA, LLC. 2025. All rights reserved. Zepbound^® is a registered trademark and boundfor™ is a trademark owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.

13:18-13:20
[Animated Lilly Medicine logo appears on screen]
CAPTION Lilly A MEDICINE COMPANY

Meet Heather

Heather loves spending time with her kids – and spending time with them this year is top of mind for her. Hear more about her personal story.

Already taking Zepbound?

We might be back in touch to talk about sharing your experiences in our materials to help motivate others.

Beyond the Measure: Real experts weigh in

Hear directly from experts on common questions around chronic weight management and Zepbound.

00:00-00:02
[White fade into Tim Bo on screen talking to camera]
**TIM BO: Let’s get some facts.**

00:02-00:04
[Tim Bo jogging on track]
**CAPTION:** YOUR QUESTIONS

00:04-00:05
[Heather walking outside]
**CAPTION:** REAL ANSWERS

00:05-00:06
[Tim Bo in a gym]
**CAPTION:** EXPERTS WEIGH IN

00:06-00:09
[Heather in her garden]
**CAPTION:** REAL ANSWERS

00:09-00:00:13
[Animated intro sequence appears]
**CAPTION:** BEYOND THE MEASURE
REAL EXPERTS WEIGH IN

00:13-00:18
[Animated intro sequence with Zepbound Logo appears]
**CAPTION:** MYTHS AND MISCONCEPTIONS
POWERED BY once weekly Zepbound^® (tirzepatide) injection 0.5 mL 2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg

00:18-00:23
[White screen fades in]
**CAPTION:** Before viewing this episode, please see the safety information.

00:23-00:26
[Animated intro sequence with Zepbound Logo appears]
**CAPTION:** once weekly Zepbound^® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5 mg| 15mg

00:26-01:11
[Opening indications appears and remains on-screen until the narrator concludes]
NARRATOR: Zepbound is an injectable prescription medicine that may help adults with obesity, or some adults with overweight who also have weight-related medical problems, to lose excess body weight and keep the weight off. It may also help adults with moderate-to-severe obstructive sleep apnea (OSA) and obesity to improve their OSA. It should be used with a reduced-calorie diet and increased physical activity.

Zepbound contains tirzepatide and should not be used with other tirzepatide-containing products or any GLP-1 receptor agonist medicines. It is not known if Zepbound is safe and effective for use in children.

01:11-1:56
NARRATOR: Select Safety Information Warning. Tell your healthcare provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In studies with rats, Zepbound and medicines that work like Zepbound caused thyroid tumors, including thyroid cancer. It is not known if Zepbound will cause thyroid tumors, or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people. Do not take Zepbound if you or any of your family have ever had MTC or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
**NARRATOR: See Indications and Safety Summary with Warnings at the end of this video.**

**CAPTION: See Indications and Safety Summary with Warnings at the end of this video.**

01:56-02:07
[White fade into Tim Bo on screen talking to camera]
**CAPTION:** Tim Bo
Real Zepbound Patient
**TIM BO: Welcome to Beyond the Measure, a show where we dive into some of the most commonly asked questions and misconceptions about obesity and Zepbound.**

02:07-02:14
[Animated green logo transitions to Tim Bo on screen talking to camera]
**CAPTION:** Tim Bo
Real Zepbound Patient
**TIM BO: This show is dedicated to separating facts from fiction and helping you with your weight loss journey.**

02:07-02:14
[Animated green logo transitions to Tim Bo on screen talking to camera]
**CAPTION:** Tim Bo
Real Zepbound Patient
**TIM BO: This show is dedicated to separating facts from fiction and helping you with your weight loss journey.**

02:14-02:26
[Animated green logo transitions to Tim Bo on screen talking to camera]
**CAPTION:** Tim Bo
Real Zepbound Patient
Hi, I’m Tim Bo, I’m taking Zepbound along with diet and exercise and I’ve lost significant weight and I have kept it off.
**CAPTION:** Throughout a 17-month clinical trial, people who took Zepbound sustained weight loss—whether taking the 5-mg, 10-mg, or 15-mg dose.^*†
**Zepbound is not for cosmetic weight loss.**
^*Along with a reduced-calorie diet and increased physical activity.
^†Individual results may vary. In studies, average weight loss in adults with or without diabetes was ~15% (34 lbs) on 5 mg, ~13-20% (28-44 lbs) on 10 mg, and ~15-21% (33-48 lbs) on 15 mg compared to ~3% (7 lbs) on placebo. Avg. baseline weights were ~220-233 Ibs.

02:27-02:32
[B-roll of Tim Bo doing different activities and then Tim Bo speaking to camera]
**CAPTION:** Tim Bo
Real Zepbound Patient
**TIM BO: I wanted to help get more people like me the answers they want. That’s why I’m going to ask a professional, Dr. Alexander…**

02:32-02:42
[Tim Bo speaking to camera]
**CAPTION:** Tim Bo
Real Zepbound Patient
**TIM BO: some of the most frequently asked questions and misconceptions about obesity and how Zepbound together with diet and exercise may help with the challenges of weight loss.**

02:43-03:02
[Animated green logo transitions to Dr. Alexander on screen talking to camera]
**CAPTION:** Lydia Alexander MD, FOMA, Obesity Medicine Association
DR. ALEXANDER: Hello everyone, I'm Doctor Lydia Alexander. I am a board-certified internal medicine and obesity specialist and currently serve as the chief medical officer at Enara Health in San Mateo, CA. I'm passionate about advancing the field of chronic weight management and improving the lives of patients affected by the disease of obesity.

03:02-03:05
[Animated green logo transitions to Dr. Alexander on screen talking to camera]
**CAPTION:** Lydia Alexander MD, FOMA, Obesity Medicine Association
**DR. ALEXANDER: Why don’t we get started.**

03:05-03:12
[Animated green logo transitions to Tim Bo on screen talking to camera. “What are some myths about obesity? Appears in sidebar and remains until the end of the question.]
**TIM BO: So, is the only thing an adult with obesity needs to do to lose weight, and keep it off, is put their mind to it?**

03:12-03:26
[Animated green logo transitions to Dr. Alexander on screen talking to camera]
DR. ALEXANDER: Despite the reality that obesity is a complex disease, many believe that obesity is the result of poor choices and a lack of willpower. But the science says otherwise. Obesity is a disease with many causes, including

03:26-03:34
[White fade to animated icons]
**DR. ALEXANDER: our genes, mental health and wellbeing, environment, society and culture, behavior, and our body’s**

03:34-03:49
[White fade to Dr. Alexander on screen talking to camera]
DR. ALEXANDER: processes. Though some people start losing weight with diet and exercise alone, many can’t keep off the weight they lose. It can be extremely challenging—and can leave you feeling stuck. The problem?

03:49-03:57
[White fade to animated icons]
**DR. ALEXANDER: When you start to lose weight, your body may respond by resisting and making you hungrier. It’s why keeping the weight off can be so difficult.**

03:57-04:19
[White fade to Dr. Alexander on screen talking to camera]
DR. ALEXANDER: So to answer your question—no—not everyone can lose weight when they want to, even if they’re eating a healthy diet and working out. That’s why having chronic weight management medications along with a reduced-calorie diet and increased physical activity may be a good option for those adults to discuss with their healthcare providers.

04:19-04:41
[Animated green logo transitions to Dr. Alexander on screen talking to camera]
DR. ALEXANDER: It's important to also remember that everyone is unique. Everybody has individual challenges with obesity. Zepbound—along with diet and exercise—may be a tool that helps patients to lose weight and keep it off. But always remember to consult with your doctor to decide if Zepbound is right for you.
**CAPTION:** Zepbound is an injectable prescription medicine that may help adults with obesity, or with excess weight (overweight) who also have weight-related medical problems, lose weight and keep it off. Zepbound should be used with a reduced-calorie diet and increased physical activity.

04:41-04:45
[Transition to Tim Bo on screen talking to camera “How does Zepbound work?” Appears in sidebar and remains until the end of the question.]
**TIM BO: Can you explain how Zepbound works?**

04:45-05:12
[Transition to Dr. Alexander on screen talking to camera]
DR. ALEXANDER: Zepbound is the first and only obesity treatment of its kind and it works differently from other chronic weight management medications by working with your body to activate the receptors of two naturally-occurring hormones known as GIP and GLP-1. Why does this matter? I usually tell my patients—Zepbound reduces appetite and food intake. In short, it reduces your desire for food and how much you eat.
**CAPTION:** GIP is glucose-dependent insulinotropic polypeptide. GLP-1 is glucagon-like peptide-1.

05:12-05:15
[Transition to Tim Bo on screen talking to camera “Does injection location matter?” Appears in sidebar and remains until the end of the question.]
**TIM BO: Does it matter where I inject Zepbound?**

05:15-05:36
[Transition to Dr. Alexander on screen talking to camera]
DR. ALEXANDER: Zepbound must be injected subcutaneously—or under the skin—but only in the stomach, thigh, or upper arm. You or another person can inject the medicine in your stomach or thigh. Another person should give you the injection in the back of your upper arm. And remember to note on a weekly basis the site you use.
**CAPTION:** Read the Instructions for Use that comes with Zepbound.

05:36-05:39
[Transition to Tim Bo on screen talking to camera “Why recall injection site?” Appears in sidebar and remains until the end of the question.]
**TIM BO: Why do I need to remember where Zepbound was injected?**

05:41-05:58
[Transition to Dr. Alexander on screen talking to camera]
DR. ALEXANDER: Good question. Because, although you may use the same “area” of your body, it’s important to rotate your injection site each week. So, be sure to choose a different injection site in that area. Your doctor can also help you with making these choices to ensure they are right for you.
**CAPTION:** Read the Instructions for Use that comes with Zepbound.

05:59-06:03
[Transition to Tim Bo on screen talking to camera “Who is a candidate for Zepbound?” Appears in sidebar and remains until the end of the question.]
**TIM BO: Another common question is, am I someone who should take Zepbound?**

06:04-06:51
[Transition to Dr. Alexander on screen talking to camera]
**DR. ALEXANDER: Good question. The first thing I’d recommend…it’s important to discuss this with a doctor who knows your personal health history.**
You should also learn everything you can about Zepbound, an injectable prescription medication to help adults with a body mass index [BMI] of 30 or greater. Or, a BMI of 27 or greater with a weight-related medical condition, such as high blood pressure, lipid disorders, and type 2 diabetes.
How do you determine your BMI? You can easily find online calculators that will help you. All you need to know is your height and weight. Once you know your BMI, talk to your doctor; together, you can decide if Zepbound is right for you.
**CAPTION:** Zepbound is an injectable prescription medicine that may help adults with obesity, or with excess weight (overweight) who also have weight-related medical problems, lose weight and keep it off. Zepbound should be used with a reduced-calorie diet and increased physical activity.

06:52-07:01
[Transition to Tim Bo on screen talking to camera.]
**TIM BO: Thank you for answering all of these questions. All of these topics are so important and I’m glad others looking into this will have these answers as a resource.**

07:02-07:12
[Transition to Dr. Alexander on screen talking to camera]
DR. ALEXANDER: I’m so glad I had the opportunity to answer these questions today. Obesity is a real disease, so it’s important that we make information like this accessible to those who need it.

07:13-07:18
[Zepbound end card appears on screen]
**CAPTION:** once weekly zepbound^® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5 mg | 15mg A Lilly Medicine visit www.zepbound.lilly.com or call 1-800-LillyRX for pricing information

7:19-7:21
[Animated Lilly Medicine logo appears on screen]
**CAPTION:** Lilly A MEDICINE COMPANY

7:23-8:13
[Animated data and safety claims appear on screen]
**CAPTION:** INDICATIONS AND SAFETY SUMMARY WITH WARNINGS

once weekly zepbound^® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5 mg | 15mg
**NARRATOR: Indications and safety summary with warnings. Zepbound^® is an injectable prescription medicine that may help adults with:**

**obesity, or** **some adults with overweight who also have weight-related medical problems to lose excess body weight and keep the weight off.**

**moderate-to-severe obstructive sleep apnea (OSA) and obesity to improve their OSA.**

It should be used with a reduced-calorie diet and increased physical activity. Zepbound contains tirzepatide and should not be used with other tirzepatide-containing products or any GLP-1 receptor agonist medicines. It is not known if Zepbound is safe and effective for use in children.

8:14-9:30
**CAPTION:** INDICATIONS AND SAFETY SUMMARY WITH WARNINGS once weekly zepbound^® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5 mg | 15mg
NARRATOR: Warnings. Zepbound may cause tumors in the thyroid, including thyroid cancer. Watch for possible symptoms, such as a lump or swelling in the neck, hoarseness, trouble swallowing, or shortness of breath. If you have any of these symptoms, tell your healthcare provider. Do not use Zepbound if you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC). Do not use Zepbound if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Do not use Zepbound if you have had a serious allergic reaction to tirzepatide or any of the ingredients in Zepbound. Zepbound may cause serious side effects, including severe stomach problems. Stomach problems, sometimes severe, have been reported in people who use Zepbound. Tell your healthcare provider if you have stomach problems that are severe or will not go away. Kidney problems, kidney failure, diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration), which may cause kidney problems. It is important for you to drink fluids to help reduce your chance of dehydration.

9:31-11:07
**CAPTION:** INDICATIONS AND SAFETY SUMMARY WITH WARNINGS once weekly zepbound^® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5 mg | 15mg

NARRATOR: Gallbladder problems. Gallbladder problems have happened in some people who use Zepbound. Tell your healthcare provider right away if you get symptoms of gallbladder problems, which may include pain in your upper stomach, abdomen, fever, yellowing of skin or eyes, jaundice, or clay-colored stools. Inflammation of the pancreas (pancreatitis). Stop using Zepbound and call your healthcare provider right away. If you have severe pain in your stomach area, abdomen, that will not go away with or without vomiting, you may feel the pain from your abdomen to your back. Serious allergic reactions. Stop using Zepbound and get medical help right away if you have any symptoms of a serious allergic reaction, including swelling of your face, lips, tongue, or throat, problems breathing or swallowing, severe rash or itching, fainting or feeling dizzy, or very rapid heartbeat. Low blood sugar (hypoglycemia). Your risk for getting low blood sugar may be higher if you use Zepbound with medicines that can cause low blood sugar, such as a sulfonylurea or insulin. Signs and symptoms of low blood sugar may include dizziness or lightheadedness, sweating, confusion or drowsiness, headache, blurred vision, slurred speech, shakiness, fast heartbeat, anxiety, irritability, mood changes, hunger, weakness or feeling jittery.

11:08-12:02
**CAPTION:** INDICATIONS AND SAFETY SUMMARY WITH WARNINGS once weekly zepbound^® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5 mg | 15mg NARRATOR: Changes in vision in patients with type two diabetes. Tell your healthcare provider if you have changes in vision during treatment with Zepbound. Depression or thoughts of suicide. You should pay attention to changes in your mood, behaviors, feelings, or thoughts. Call your healthcare provider right away if you have any mental changes that are new, worse, or worry you.

Food or liquid getting into the lungs during surgery or other procedures that use anesthesia or deep sleepiness (deep sedation). Zepbound may increase the chance of food getting into your lungs during surgery or other procedures. Tell all your healthcare providers that you are taking Zepbound before you are scheduled to have surgery or other procedures.

Common side effects. The most common side effects of Zepbound include nausea, diarrhea, vomiting, constipation, stomach (abdominal) pain, indigestion, injection site reactions, feeling tired, allergic reactions, belching, hair loss, and heartburn. These are not all the possible side effects of Zepbound. Talk to your healthcare provider about any side effect that bothers you or doesn't go away.

12:03-13:06
**CAPTION:** INDICATIONS AND SAFETY SUMMARY WITH WARNINGS once weekly zepbound^® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5 mg | 15mg
NARRATOR: Tell your healthcare provider if you have any side effects. You can report side effects at 1-800-FDA-1088 or www.fda.gov/medwatch. Before using Zepbound. Your healthcare provider should show you how to use Zepbound before you use it for the first time. Tell your healthcare provider if you are taking medicines to treat diabetes, including an insulin or sulfonylurea which could increase your risk of low blood sugar. Talk to your healthcare provider about low blood sugar levels and how to manage them. If you take birth control pills by mouth, talk to your healthcare provider before you use Zepbound. Birth control pills may not work as well while using Zepbound. Your healthcare provider may recommend another type of birth control for four weeks after you start Zepbound and for 4 weeks after each increase in your dose of Zepbound.

13:07-13:58
**CAPTION:** INDICATIONS AND SAFETY SUMMARY WITH WARNINGS once weekly zepbound^® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5 mg | 15mg

NARRATOR: Review these questions with your healthcare provider. Do you have other medical conditions, including problems with your pancreas or kidneys, or severe problems with your stomach, such as slowed emptying of your stomach (gastroparesis) or problems digesting food? Do you take diabetes medicines such as insulin or sulfonylureas? Do you have a history of diabetic retinopathy? Do you take any other prescription medicines or over the counter drugs, vitamins, or herbal supplements? Are you pregnant, plan to become pregnant, breastfeeding, or plan to breastfeed? Zepbound may harm your unborn baby. Tell your healthcare provider if you become pregnant while using Zepbound. It is not known if Zepbound passes into your breast milk. You should talk with your healthcare provider about the best way to feed your baby while using Zepbound.

13:59-15:13
**CAPTION:** INDICATIONS AND SAFETY SUMMARY WITH WARNINGS once weekly zepbound^® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5 mg | 15mg

NARRATOR: Pregnancy Exposure Registry. There will be a pregnancy exposure registry for women who have taken Zepbound during pregnancy. The purpose of this registry is to collect information about the health of you and your baby. Talk to your healthcare provider about how you can take part in this registry. Or you may contact Lily at 1-800-LillyRX (1-800-545-5979). How to take. Read the Instructions for Use that come with Zepbound. Use Zepbound exactly as your healthcare provider says. Use Zepbound with a reduced-calorie diet and increased physical activity. Zepbound is injected under the skin (subcutaneously) of your stomach, abdomen, thigh, or upper arm. Use Zepbound 1 time each week at any time of the day. Change (rotate) your injection site with each weekly injection. Do not use the same site for each injection. If you take too much Zepbound, call your healthcare provider, seek medical advice promptly, or contact a poison center expert right away at 1-800-222-1222.

**Zepbound injection is approved as a 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, or 15 mg per 0.5 mL in single-dose pen or single-dose vial.**

15:14-16:02
**CAPTION:** INDICATIONS AND SAFETY SUMMARY WITH WARNINGS once weekly zepbound^® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5 mg | 15mg
NARRATOR: Learn more. Zepbound is a prescription medicine. For more information, call 1-800-LillyRX (1-800-545-5979) [or go to www.Zepbound.lilly.com]. This summary provides basic information about Zepbound, but does not include all information known about this medicine. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your healthcare provider. Be sure to talk to your healthcare provider about Zepbound and how to take it. Your healthcare provider is the best person to help you decide if Zepbound is right for you.

**CAPTION:** INDICATIONS AND SAFETY SUMMARY WITH WARNINGS once weekly zepbound^® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5 mg | 15mg

**CAPTION:** ZP CON BS20DEC2024. Zepbound^® and its delivery device base are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.

16:03 – 16:06
[Animated Zepbound logo appears on screen]
**CAPTION:** once weekly zepbound^® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5 mg | 15mg visit www.zepbound.com or call 1-800-LillyRX
A Lilly Medicine
PP-ZP-US-1547 01/2025 ©Lilly USA, LLC. 2025. All rights reserved. Zepbound^® is a registered trademark owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.

16:07-16:09
[Animated Lilly Medicine logo appears on screen]
**CAPTION:** Lilly A MEDICINE COMPANY

Myths and Misconceptions

In this episode, Dr. Lydia Alexander answers common questions about obesity and Zepbound.

Learn about cost and potential savings for Zepbound

Explore savings

Check in with Tim Bo and Heather to learn more about their weight loss journeys.

This page is for people like Noelle

The determined individual who keeps trying to lose weight.

Who is frustrated, but wants to find a treatment option that may work for them along with diet and exercise.

Who knows this is a continued journey but is excited to explore the possibility of weight loss change.

What are you bound for?

Already taking Zepbound?

We might be back in touch to talk about sharing your experiences in our materials to help motivate others.

Real stories.
Real patients.

Real stories.
Real patients.

What is Zepbound?

Select Safety Information

Warning:

Real Zepbound stories

Already taking Zepbound?

Beyond the Measure: Real experts weigh in

Learn about cost and potential savings for Zepbound

Check Ins with TimBo and Heather

Want to be bound for more information?

Check in with Tim Bo and Heather to learn more about their weight loss journeys.

What are you boundfor^TM

Learn how you could save on Zepbound no matter your insurance status

This page is for people like Noelle

Already taking Zepbound?

Want to be bound for more information?

SAFETY SUMMARY WITH WARNINGS

Warning:

INDICATIONS

Real stories.Real patients.

Real stories.Real patients.

What is Zepbound?

Select Safety Information

Warning:

Real Zepbound stories

Already taking Zepbound?

Beyond the Measure: Real experts weigh in

Learn about cost and potential savings for Zepbound

Check Ins with TimBo and Heather

Want to be bound for more information?

Check in with Tim Bo and Heather to learn more about their weight loss journeys.

What are you boundforTM

Learn how you could save on Zepbound no matter your insurance status

This page is for people like Noelle

Already taking Zepbound?

Want to be bound for more information?

SAFETY SUMMARY WITH WARNINGS

Warning:

INDICATIONS

Real stories.
Real patients.

Real stories.
Real patients.

What are you boundfor^TM