00:00-00:05
[Animated intro sequence appears]
CAPTION: Please see the safety information before Noelle’s story.
00:05-00:09
[Animated intro sequence with Zepbound Logo appears]
CAPTION: once weekly Zepbound® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg
| 10mg |
12.5 mg| 15mg
A Lilly Medicine
visit www.zepbound.lilly.com or call 1-800-LillyRX for pricing
information
00:09-00:52
[Opening indication appears and remains on-screen until the narrator concludes]
NARRATOR: Zepbound is an injectable prescription medicine that may help adults
with
obesity, or with excess weight (overweight) who also have weight-related medical problems, lose weight
and keep it
off. Zepbound should be used with a reduced-calorie diet and increased physical activity.
Zepbound contains tirzepatide and should not be used with other
tirzepatide-containing
products or any GLP-1 receptor agonist medicines. It is not known if Zepbound is safe and effective
when taken
with other prescription, over-the-counter, or herbal weight loss products. It is not known if Zepbound
can be used
in people who have had pancreatitis. It is not known if Zepbound is safe and effective for use in
children under
18 years of age.
00:53-01:34
NARRATOR: Select Safety Information. Warning. Tell your healthcare provider if you get a
lump
or swelling
in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid
cancer. In
studies with rats, Zepbound and medicines that work like Zepbound caused thyroid tumors, including
thyroid cancer.
It is not known if Zepbound will cause thyroid tumors, or a type of thyroid cancer called medullary
thyroid
carcinoma (MTC) in people. Do not take Zepbound if you or any of your family have ever had MTC or if
you have an
endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN
2).
CAPTION: See Indication and Safety Summary with Warnings at the end of this
video.
01:35-01:42
[Ambient music, ocean waves, and seagull sounds play in the background; Noelle
standing on beach,
looking out at the water]
CAPTION: Noelle was a Zepbound clinical trial
participant and was
compensated for her time. Individual results may vary. Talk to your doctor to see if Zepbound® is
right for you.
NOELLE: I was stuck for 15 to probably 18 years. I tried multiple trends to
lose weight
and nothing would work.
01:42—1:48
[Noelle is on screen speaking to the camera]
NOELLE: Up until I was 30, I was pretty athletic, slender, was always
out
01:49—1:51
[Noelle and her friends doing Tai Chi on the beach]
NOELLE: with my friends, doing fun things, so I stayed pretty
01:51—1:54
[Noelle doing Tai Chi alone on the beach.]
NOELLE: thin. Well, once I had a baby
01:54—1:58
[Noelle is on screen speaking to camera.]
NOELLE: I was putting on five, 10 pounds a year.
01:58—2:02
[Noelle doing Tai Chi alone on the beach, looking reflective.
NOELLE: It sneaks up on you, you know? And after
02:02—2:06
[Noelle is on screen speaking to camera.]
NOELLE: turning 40, it was impossible for me to lose weight
02:06—2:12
[Noelle and her friends doing Tai Chi on the beach.]
NOELLE: I would start a diet. I’d lose weight, then I’d hit a
certain point
and
02:12—2:16
[Noelle and her friends doing Tai Chi on the beach.]
NOELLE: it just would stop coming off. And then I finally went to my doctor
for
02:16—2:22
[Noelle is on screen talking to camera.]
NOELLE: help, they told me I was overweight and that I had high blood
pressure.
02:22—2:24
[Noelle is on screen talking to camera.]
NOELLE: For myself,
02:24—2:29
[Pictures of Noelle and her son appear on screen.]
NOELLE: for my son, and for my family – there needed to be a
change.
02:29—2:34
[Noelle is on screen talking to camera.]
CAPTION: Individual results may vary. Talk to your doctor to see if Zepbound® is
right for you.
>NOELLE: When taking Zepbound along with diet and exercise,
02:29—2:34
[Noelle is on screen talking to camera.]
CAPTION: Throughout a 17-month clinical trial, people who dieted,
exercised,* and took
Zepbound
sustained weight loss—whether taking the 5-mg, 10-mg, or 15-mg dose.†
SUPER: Zepbound is not for cosmetic weight loss.
Along with a reduced-calorie diet and increased physical activity. Individual results may vary. In
studies, average weight loss in adults with or without diabetes was ~15% (34 lbs) on 5
mg,
~13-20%
(28-
44 lbs) on 10 mg, and ~15-21% (33-48 lbs) on 15 mg compared to
~3% (7
lbs) on placebo. Avg. baseline weights were ~220-233 Ibs.
NOELLE: I was able to lose significant weight and maintain my weight loss
during the
trial.
02:40—2:51
[Pictures from Noelle’s weight loss journey appear on screen.]
CAPTION: Throughout a 17-month clinical trial, people who dieted,
exercised,* and
took Zepbound sustained weight loss—whether taking the 5-mg, 10-mg, or 15-mg
dose.†
SUPER: Zepbound is not for cosmetic weight loss.
Along with a reduced-calorie diet and increased physical activity. Individual results may vary. In
studies,
average weight loss in adults with or without diabetes was ~15% (34 lbs) on 5 mg,
~13-20%
(28-
44 lbs) on 10 mg, and ~15-21% (33-48 lbs) on 15 mg compared to
~3% (7
lbs) on placebo. Avg. baseline weights were ~220-233 Ibs.
NOELLE: I was a size 22. As I started taking the medication and went down to
size 18 and
then eventually 16 and 14.
02:51—2:54
[Noelle doing Zumba in a backyard.]
CAPTION: Zepbound is not for cosmetic weight loss.
Along with diet and exercise.
Individual results may vary. In studies, average weight loss in adults with or without diabetes was
~15%
(34 lbs) on 5 mg, ~13-20% (28-44 lbs) on 10 mg, and ~15-21% (33-48
lbs)
on 15 mg compared to ~3% (7 lbs) on placebo. Avg. baseline weights were
~220-233
Ibs.
NOELLE: When I eventually got down to 12, I was like
02:54—02:57
[Noelle doing Zumba in a backyard.]
CAPTION: Zepbound is not for cosmetic weight loss.
Along with diet and exercise.
Individual results may vary. In studies, average weight loss in adults with or without diabetes was
~15%
(34 lbs) on 5 mg, ~13-20% (28-44 lbs) on 10 mg, and ~15-21% (33-48
lbs)
on 15 mg compared to ~3% (7 lbs) on placebo. Avg. baseline weights were
~220-233
Ibs.
NOELLE: this is the most exciting thing ever.
02:57—03:00
[Noelle doing Zumba in a backyard.]
CAPTION: Zepbound is not for cosmetic weight loss.
Along with diet and exercise.
Individual results may vary. In studies, average weight loss in adults with or without diabetes was
~15%
(34 lbs) on 5 mg, ~13-20% (28-44 lbs) on 10 mg, and ~15-21% (33-48
lbs)
on 15 mg compared to ~3% (7 lbs) on placebo. Avg. baseline weights were
~220-233
Ibs.
NOELLE: I feel seen.
03:00—03:03
[Noelle doing Zumba in a backyard.]
CAPTION: Zepbound is not for cosmetic weight loss.
Along with diet and exercise.
Individual results may vary. In studies, average weight loss in adults with or without diabetes was
~15%
(34 lbs) on 5 mg, ~13-20% (28-44 lbs) on 10 mg, and ~15-21% (33-48
lbs)
on 15 mg compared to ~3% (7 lbs) on placebo. Avg. baseline weights were
~220-233
Ibs.
NOELLE: I love dancing, so you know, I am too old to go to the
03:03—03:08
[Noelle doing Zumba in a backyard.]
CAPTION: Zepbound is not for cosmetic weight loss.
Along with diet and exercise.
Individual results may vary. In studies, average weight loss in adults with or without diabetes was
~15%
(34 lbs) on 5 mg, ~13-20% (28-44 lbs) on 10 mg, and ~15-21% (33-48
lbs)
on 15 mg compared to ~3% (7 lbs) on placebo. Avg. baseline weights were
~220-233
Ibs.
NOELLE: nightclubs. (laughs) So, my nightclub is Zumba.
03:08—03:10
[Ambient sounds of the ocean, Noelle and her friends walking arm in arm along the beach.]
CAPTION: Zepbound is not for cosmetic weight loss.
Along with diet and exercise.
Individual results may vary. In studies, average weight loss in adults with or without diabetes was
~15%
(34 lbs) on 5 mg, ~13-20% (28-44 lbs) on 10 mg, and ~15-21% (33-48
lbs)
on 15 mg compared to ~3% (7 lbs) on placebo. Avg. baseline weights were
~220-233
Ibs.
NOELLE: I love enjoying
03:10—03:12
[Ambient sounds of Noelle and her friends talking, Noelle and her friends are
enjoying a
picnic on the
beach.]
CAPTION: Zepbound is not for cosmetic weight loss.
Along
with diet
and exercise.
Individual results may vary. In studies, average weight loss in adults with or without diabetes was
~15%
(34 lbs) on 5 mg, ~13-20% (28-44 lbs) on 10 mg, and ~15-21% (33-48
lbs)
on 15 mg compared to ~3% (7 lbs) on placebo. Avg. baseline weights were
~220-233
Ibs.
NOELLE: the sun
03:12—03:20
[Ambient sounds of Noelle and her friends talking, Noelle and her friends are
enjoying a
picnic on the
beach.]
NOELLE: and having great food with great friends. And the food is actually good for
you.
03:20—03:28
[Noelle is on screen talking to camera.]
NOELLE: All these times when I
was trying
to lose weight and couldn’t, I just felt like
well my
body
03:28—03:31
[Noelle holds a coffee mug and slowly lifts it up.]
NOELLE: likes the
weight, and
there’s nothing I can do.
03:31—03:37
[Noelle drinks from a coffee mug in a backyard space.]
NOELLE: And what was surprising with
Zepbound was
that my body did wanna lose weight. I would
eat
half
03:37—03:38
[Noelle is on screen talking to camera.]
NOELLE: of what I used to
eat
03:38—03:41
[Noelle is in backyard, holding a coffee mug looking out at the
sky.]
NOELLE: and
feel satisfied.
03:41—03:43
[Noelle is doing Tai Chi alone on the beach.]
NOELLE: I feel the
best
03:43—03:45
[Noelle is doing Zumba in the backyard.]
NOELLE: part of this
03:45—03:46
[Noelle looks out up and around on the beach.]
NOELLE: journey is
that
03:46—03:47
[Noelle is hiking alone on a trail, smiling.]
NOELLE: I am
03:47—03:49
[Noelle is on screen talking to camera.]
NOELLE: a role model to my
child.
03:49—03:52
Noelle and her son are hiking and talking.]
NOELLE: You’re always looking for a new goal to
hit
03:52—03:54
[Noelle and her son are hiking and talking.]
NOELLE:
knock
that off my bucket list, you
know?
03:54—03:59
[Noelle and her son look at each other during a pause on the
hike.]
NOELLE: I think
he’s very proud of me. I think he looks at me as inspiration and he knows
I’m
03:59—04:02
[Noelle and her son pause to take a selfie on their hike.]
NOELLE:
doing it for him
too.
04:02—04:04
[We see the selfie Noelle took of her and her son.]
Noelle: I’m
proud of
myself right now and I
04:04—04:06
[Noelle and her son are talking and hiking.]
NOELLE: look back at my
past self and
say, “you go
04:06—04:13
[Noelle is standing on the beach and turns to look at the camera.]
NOELLE: girl.” I’m bound for new ways to celebrate the love I have for
myself.
04:13-04:15
[Animated Zepbound logo appears on screen]
CAPTION: once weekly
Zepbound® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5 mg| 15mg
A Lilly
Medicine visit
www.zepbound.lilly.com or call 1-800-LillyRX for pricing
information
04:15-04:17
[Animated Lilly
Medicine logo appears on screen]
CAPTION: Lilly
A MEDICINE COMPANY
04:17-05:09
[Animated data and safety claims appear on screen]
CAPTION: INDICATION AND
SAFETY
SUMMARY
WITH WARNINGS
once weekly Zepbound® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg
| 10mg |
12.5 mg|
15mg
NARRATOR: Indication and Safety Summary with Warnings.
Zepbound® is an injectable prescription medicine that may help
adults with
obesity, or with excess weight (overweight) who also have weight-related medical problems, lose weight
and keep it
off. It should be used with a reduced-calorie diet and increased physical activity. Zepbound contains
tirzepatide
and should not be used with other tirzepatide-containing products or any GLP-1 receptor agonist
medicines. It is
not known if Zepbound is safe and effective when taken with other prescription, over-the-counter, or
herbal weight
loss products. It is not known if Zepbound can be used in people who have had pancreatitis. It is not
known if
Zepbound is safe and effective for use in children under 18 years of age.
05:09-06:26
CAPTION: INDICATION AND SAFETY SUMMARY WITH WARNINGS
once weekly
Zepbound® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5 mg|
15mg
NARRATOR:
Warnings. Zepbound may cause tumors in the thyroid, including thyroid cancer. Watch for possible
symptoms, such as
a lump or swelling in the neck, hoarseness, trouble swallowing, or shortness of breath. If you have
any of these
symptoms, tell your healthcare provider. Do not use Zepbound if you or any of your family have ever
had a type of
thyroid cancer called medullary thyroid carcinoma (MTC). Do not use Zepbound if you have Multiple
Endocrine
Neoplasia syndrome type 2 (MEN 2). Do not use Zepbound if you have had a serious allergic reaction to
tirzepatide
or any of the ingredients in Zepbound. Zepbound may cause serious side effects, including, severe
stomach
problems. Stomach problems, sometimes severe, have been reported in people who use Zepbound. Tell your
healthcare
provider if you have stomach problems that are severe or will not go away. Kidney problems (kidney
failure).
Diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration), which may cause kidney
problems. It is
important for you to drink fluids to help reduce your chance of dehydration.
06:26-08:03
CAPTION: INDICATION AND SAFETY SUMMARY WITH WARNINGS
once
weekly
Zepbound® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5 mg|
15mg
NARRATOR:
Gallbladder problems. Gallbladder problems have happened in some people who use
Zepbound. Tell
your healthcare provider right away if you get symptoms of gallbladder problems, which may include
pain in your
upper stomach (abdomen), fever, yellowing of skin or eyes (jaundice), or clay-colored stools.
Inflammation of the
pancreas (pancreatitis). Stop using Zepbound and call your healthcare provider right away if you have
severe pain
in your stomach area (abdomen) that will not go away, with or without vomiting. You may feel the pain
from your
abdomen to your back. Serious allergic reactions. Stop using Zepbound and get medical help right away
if you have
any symptoms of a serious allergic reaction, including swelling of your face, lips, tongue or throat,
problems
breathing or swallowing, severe rash or itching, fainting or feeling dizzy, or very rapid heartbeat.
Low blood
sugar (hypoglycemia). Your risk for getting low blood sugar may be higher if you use Zepbound with
medicines that
can cause low blood sugar, such as a sulfonylurea or insulin. Signs and symptoms of low blood sugar
may include
dizziness or light-headedness, sweating, confusion or drowsiness, headache, blurred vision, slurred
speech,
shakiness, fast heartbeat, anxiety, irritability, mood changes, hunger, weakness or feeling
jittery.
08:03-08:57
CAPTION: INDICATION AND SAFETY SUMMARY WITH WARNINGS
once weekly
Zepbound® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5 mg|
15mg
NARRATOR:
Changes in vision in patients with type 2 diabetes. Tell your healthcare provider if you have changes
in vision
during treatment with Zepbound. Depression or thoughts of suicide. You should pay attention to changes
in your
mood, behaviors, feelings or thoughts. Call your healthcare provider right away if you have any mental
changes
that are new, worse, or worry you. Common side effects. The
most common
side effects of Zepbound include nausea, diarrhea, vomiting, constipation, stomach (abdominal) pain,
indigestion,
injection site reactions, feeling tired, allergic reactions, belching, hair
loss, and heartburn. These are not all the
possible
side effects of Zepbound. Talk to your healthcare provider about any side effect that bothers you or
doesn’t
go away.
08:57-10:01
CAPTION: INDICATION AND SAFETY SUMMARY WITH WARNINGS
once
weekly
Zepbound® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5 mg|
15mg
NARRATOR: Tell
your healthcare provider if you have any side effects. You can report side effects at 1-800-FDA-1088
or
www.fda.gov/medwatch. Before
using
Zepbound. Your healthcare provider should show you how to use Zepbound before you use it for the first
time. Tell
your healthcare provider if you are taking medicines to treat diabetes including insulin or
sulfonylureas which
could increase your risk of low blood sugar. Talk to your healthcare provider about low blood sugar
levels and how
to manage them. If you take birth control pills by mouth, talk to your healthcare provider before you
use
Zepbound. Birth control pills may not work as well while using Zepbound. Your healthcare provider may
recommend
another type of birth control for 4 weeks after you start Zepbound and for 4 weeks after each increase
in your
dose of Zepbound.
10:01-10:54
CAPTION: INDICATION AND SAFETY SUMMARY WITH WARNINGS
once weekly
Zepbound® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5 mg|
15mg
NARRATOR:
Review these questions with your healthcare provider. Do you have other medical conditions, including
problems
with your pancreas or kidneys, or severe problems with your stomach, such as slowed emptying of your
stomach
(gastroparesis) or problems digesting food? Do you take diabetes medicines, such as insulin or
sulfonylureas? Do
you have a history of diabetic retinopathy? Do you take any other prescription medicines or
over-the-counter
drugs, vitamins, or herbal supplements? Are you pregnant, plan to become pregnant, breastfeeding, or
plan to
breastfeed? Zepbound may harm your unborn baby. Tell your healthcare provider if you become pregnant
while using
Zepbound. It is not known if Zepbound passes into your breast milk. You should talk with your
healthcare provider
about the best way to feed your baby while using Zepbound.
10:54-12:08
CAPTION: INDICATION AND SAFETY SUMMARY WITH WARNINGS
once
weekly
Zepbound® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5 mg|
15mg
NARRATOR:
Pregnancy Exposure Registry. There will be a pregnancy exposure registry for women who have taken
Zepbound during
pregnancy. The purpose of this registry is to collect information about the health of you and your
baby. Talk to
your healthcare provider about how you can take part in this registry, or you may contact Lilly at
1-800-LillyRx
(1-800-545-5979). How to take. Read the Instructions for Use that come with Zepbound. Use Zepbound
exactly as your
healthcare provider says. Zepbound is injected under the skin (subcutaneously) of your stomach
(abdomen), thigh,
or upper arm. Use Zepbound 1 time each week, at any time of the day. Change (rotate) your injection
site with each
weekly injection. Do not use the same site for each injection. If you take too much Zepbound, call
your healthcare
provider, seek medical advice promptly, or contact a Poison Center expert right away at
1-800-222-1222.
12:08-12:54
CAPTION: INDICATION AND SAFETY SUMMARY WITH WARNINGS
once weekly
Zepbound® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5 mg|
15mg
NARRATOR: Learn
more. Zepbound is a prescription medicine. For more information, call 1-800-LillyRx (1-800-545-5979)
[or go to
www.zepbound.lilly.com].
This summary
provides basic information about Zepbound but does not include all information known about this
medicine. Read the
information that comes with your prescription each time your prescription is filled. This information
does not
take the place of talking with your healthcare provider. Be sure to talk to your healthcare provider
about
Zepbound and how to take it. Your healthcare provider is the best person to help you decide if
Zepbound is right
for you.
12:54 –12:58
CAPTION: INDICATION AND SAFETY SUMMARY WITH WARNINGS
once
weekly
Zepbound® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5 mg|
15mg
CAPTION:
ZP CON CBS 08NOV2023. Zepbound® and its delivery device base are registered trademarks
owned or
licensed by Eli
Lilly and Company, its subsidiaries, or affiliates.
12:59-13:00
[Animated Zepbound logo appears on screen]
CAPTION: once weekly
Zepbound® (tirzepatide) injection 0.5 mL 2.5mg | 5mg | 7.5mg | 10mg | 12.5 mg| 15mg
A
Lilly
Medicine
visit www.zepbound.lilly.com or call 1-800-LillyRX for pricing
information
13:00-13:02
[Animated Lilly Medicine logo appears on
screen]
CAPTION:
Lilly
A MEDICINE COMPANY