For adults with obesity or with excess weight and weight-related medical problems
Change starts with Zepbound*
*Along with reduced-calorie diet and increased physical activity.
For adults with obesity or with excess weight and weight-related medical problems
Change starts with Zepbound*
*Along with reduced-calorie diet and increased physical activity.
People taking
Zepbound 15 mg lost
up to
(~21% weight loss)*
Zepbound helps adults with obesity lose weight and keep it off. It is proven to deliver significant and sustained weight loss.*†
Zepbound is not for cosmetic weight loss.
*Along with diet and exercise.
†In a 72-week study of adults without diabetes, average weight loss was 15.0% (34 lbs) for 5 mg, 19.5% (44 lbs) for 10 mg, 20.9% (48 lbs) for 15 mg, and 3.1% (7 lbs) for placebo. Average starting weights were 226.8 lbs for 5 mg, 233.3 lbs for 10 mg, 232.8 lbs for 15 mg, and 231.0 lbs for placebo. In a 72-week study of adults with diabetes, average weight loss was 12.8% (28 lbs) for 10 mg, 14.7% (33 lbs) for 15 mg, and 3.2% (7 lbs) for placebo. Average starting weights were 222.4 lbs for 10 mg, 219.6 lbs for 15 mg, and 224.2 lbs for placebo.
4-6x more weight loss with Zepbound*
than diet and exercise alone
In a 72 week study, weight loss was 15% for 5 mg dose, 20.9% for 15 mg dose compared to 3.1% for placebo
*Along with diet and exercise.
Average percent weight loss observed across different doses at 17 months
Select Safety Information
Zepbound can cause serious side effects, including:
Severe stomach problems. Stomach problems, sometimes severe, have been reported in people who use Zepbound. Tell your healthcare provider if you have stomach problems that are severe or will not go away.
Additional health measures
In a 17-month clinical trial, people who dieted, exercised, and took Zepbound experienced improvements in:‡§
Some people taking Zepbound also experienced an increase in resting heart rate.
‡Zepbound is not for the treatment of cholesterol or blood pressure.
§Diet and exercise included a reduced-calorie meal plan and increased physical activity.
Waist size=waist circumference.
Select Safety Information
Zepbound can cause serious side effects, including:
Kidney problems (kidney failure). Diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration), which may cause kidney problems. It is important for you to drink fluids to help reduce your chance of dehydration.
What is Zepbound?
Zepbound is an injectable prescription medicine that may help adults with obesity, or some adults with overweight who also have weight-related medical problems, to lose excess body weight and keep the weight off. Zepbound should be used with a reduced-calorie diet and increased physical activity.
- Zepbound contains tirzepatide and should not be used with other tirzepatide-containing products or any GLP-1 receptor agonist medicines.
- It is not known if Zepbound is safe and effective for use in children.
Finally, there’s Zepbound—the first and only weight loss treatment of its kind||
||Zepbound activates the receptors of 2 hormones: glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1).
Zepbound tackles an underlying cause of excess weight.
It reduces appetite and how much you eat.
Zepbound works differently than other anti-obesity medications by activating 2 hormone
receptors.¶
It reduces appetite and food intake.
Getting the care you need can be quick and accessible
Explore speed, convenience, and access to focused care with independent telehealth or in-person providers through LillyDirect.
Zepbound does not sponsor or organize 5k running events. Running is shown only as an example of exercise.