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For adults with obesity or with excess weight and
weight-related medical
problems
See the Zepbound experience
Individual results may vary
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Throughout a 17-month clinical trial, people who dieted, exercised,* and took Zepbound sustained weight loss—whether taking the 5-mg, 10-mg, or 15-mg dose.†
*Reduced-calorie diet and increased physical activity.
†Individual results may vary. In a 72-week study of adults without diabetes, average weight loss was 15.0% (34 lbs) for 5 mg, 19.5% (44 lbs) for 10 mg, 20.9% (48 lbs) for 15 mg, and 3.1% (7 lbs) for placebo. In a 72-week study of adults with diabetes, average weight loss was 12.8% (28 lbs) for 10 mg, 14.7% (33 lbs) for 15 mg, and 3.2% (7 lbs) for placebo.
Average starting weight was 231 lbs in adults without diabetes and 222 lbs in adults with diabetes.
Average percent weight loss observed across different doses at 17 months
Overall change in body weight after 17 months in adults without diabetes was a loss of 15.0% (34 lbs) for 5 mg, 19.5% (44 lbs) for 10 mg, 20.9% (48 lbs) for 15 mg, and 3.1% (7 lbs) for placebo. Average starting weight was 231 lbs.
Zepbound should not be used for cosmetic weight loss.
Select Safety Information
Zepbound can cause serious side effects, including:
Severe stomach problems. Stomach problems, sometimes severe, have been reported in people who use Zepbound. Tell your healthcare provider if you have stomach problems that are severe or will not go away.
Additional health measures
In a 17-month clinical trial, people who dieted, exercised, and took Zepbound observed changes inǁ¶:
ǁZepbound is not for the treatment of cholesterol or blood pressure.
¶Diet and exercise included a reduced-calorie meal plan and increased physical activity.
Waist size=waist circumference.
Select Safety Information
Zepbound can cause serious side effects, including:
Kidney problems (kidney failure). Diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration), which may cause kidney problems. It is important for you to drink fluids to help reduce your chance of dehydration.
What is Zepbound?
Zepbound is an injectable prescription medicine that may help adults with obesity, or with excess weight (overweight) who also have weight-related medical problems, lose weight and keep it off. Zepbound should be used with a reduced-calorie diet and increased physical activity.
- Zepbound contains tirzepatide and should not be used with other tirzepatide-containing products or any GLP-1 receptor agonist medicines.
- It is not known if Zepbound is safe and effective when taken with other prescription, over-the-counter, or herbal weight loss products.
- It is not known if Zepbound can be used in people who have had pancreatitis.
- It is not known if Zepbound is safe and effective for use in children under 18 years of age.
Zepbound tackles an underlying cause of excess weight
Zepbound works differently by activating 2 hormone receptors.** It reduces appetite, food intake, body fat, and body weight.
**GIP=glucose-dependent insulinotropic polypeptide and GLP-1=glucagon-like peptide-1.
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