
You got this: Your once-weekly Zepbound routine
You got this: Your once-weekly Zepbound routine
- Zepbound comes in a single-dose pen that requires no mixing. There's no need to see or handle the needle.
- You can take it right at home, with or without food.
Zepbound may be injected in your stomach or thigh, or the back of your upper arm with another person’s help. Don’t use the exact same spot week-to-week. Ask your healthcare provider to help you choose an injection site if you are not sure.

Prep for Zepbound
Getting started with once-weekly Zepbound injections? See how it’s done in this video.
Please also read the full Instructions for Use that come with your Zepbound pen.
00:00-00:06
[The Zepbound logo and title animate on screen. “Indications and Safety Summary with Warnings”
disclaimer sits
below.]
CAPTION: How to Use | once weekly Zepbound® (tirzepatide) injection 0.5 mL 2.5 mg | 5 mg
| 7.5 mg |
10 mg | 12.5 mg | 15 mg / A Lilly Medicine / See Indications and Safety Summary with Warnings at the end of this video.
00:06-00:35
[“Indications and Safety Summary with Warnings” disclaimer fades off screen. Indications and Limitations
of Use
fades on screen.]
CAPTION: How to Use | once weekly Zepbound® (tirzepatide) injection 0.5
mL 2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg / Lilly Medicine / Indications and Limitations of Use
NARRATOR: Indications and Limitations of Use. Zepbound is an injectable prescription medicine
that may help
adults with moderate-to-severe obstructive sleep apnea (OSA) and obesity to improve their OSA.
Zepbound should be
used with a reduced-calorie diet and increased physical activity.
Zepbound contains tirzepatide and should not be used with other tirzepatide-containing products or any GLP-1 receptor agonist medicines. It is not known if Zepbound is safe and effective for use in children.
00:35-01:10
[Select Safety Information animates on screen.]
CAPTION: How to Use | once weekly Zepbound® (tirzepatide) injection 0.5
mL 2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg / A Lilly Medicine /
Select Safety Information
NARRATOR: Select Safety Information. Tell your healthcare provider if you get a lump or swelling
in your
neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer.
In studies
with rats, Zepbound and medicines that work like Zepbound caused thyroid tumors, including thyroid
cancer. It is
not known if Zepbound will cause thyroid tumors, or a type of thyroid cancer called medullary thyroid
carcinoma
(MTC) in people. Do not take Zepbound if you or any of your family have ever had MTC or if you have an
endocrine
system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
01:10-01:15
CAPTION: Prepare for your injection / Zepbound pen and packaging / Always read the Instructions for Use and the
Medication Guide
carefully. / The 2.5 mg dose is for treatment initiation and is not intended to be a maintenance dose.
NARRATOR: Always read the Instructions for Use and the Medication Guide carefully.
01:15-01:25
[Title card swipes to reveal Alan. He is welcomingly standing in front of his home office.]
CAPTION: Actor portrayal throughout. / You got this / Please read the full Instructions
for Use
included with your Zepbound Pen.
ALAN: Hey there! I get it. A once-weekly injection is probably not you’re idea of fun, but we’ll
get through
it. You got this!
01:25-01:28
[Alan enters his home kitchen. He stands behind the kitchen counter and confidently rests his hands on
the
countertop.]
CAPTION: Storing the pen
ALAN: We can get started right over here.
01:28-01:33
[Alan turns to open his refrigerator, where the Zepbound box is stored, and removes the box from the
refrigerator.]
CAPTION: 36ºF to 46ºF
ALAN: Store your Zepbound pen in the refrigerator, at 36 to 46 degrees Fahrenheit.
01:33-01:40
[Alan places Zepbound box on kitchen counter, opens it, and removes 1 of his 4 Zepbound pens, and places
it on the
countertop, and then closes the box.]
ALAN: There are four in each box, but you’ll only use one each week.
01:40-01:55
[Alan puts the Zepbound box back in the refrigerator and confidently returns to the kitchen counter to
continue with
his instruction.]
CAPTION: Store your pen in the original carton to protect your pen from light / You can
store your
pen at room temperature up to 86°F (30°C) for up to 21 days. If you store the pen at room temperature,
do not return
the pen to the refrigerator.
ALAN: You can also store your pens at room temperature up to 86 degrees Fahrenheit for up to 21
days. If you
do that, though, make sure you don’t return the pen to the refrigerator.
1:55-02:03
[Alan warmly holds his Zepbound pen up at chest height. Zoom in on Zepbound pen.]
CAPTION: Top | Purple injection button | Lock ring | Indicator | Lock or unlock |
Medicine | Clear
base | Gray base cap | Bottom and needle end
ALAN: Here, take a look at the pen.
02:03-02:24
[Alan returns to home office enthusiastically holding his Zepbound pen. A checklist animates on screen
as Alan
describes how to properly inspect the pen.]
CAPTION: CORRECT DOSE | NOT EXPIRED | NOT DAMAGED | NOT FROZEN | COLORLESS TO SLIGHTLY
YELLOW | NOT
CLOUDY | NO PARTICLES / Always inspect your pen prior to injection.
ALAN: Before you inject, wash your hands, and check the pen label to make sure that you have the
right
medicine and dose, and that it hasn’t expired. Also, inspect the pen to make sure that it isn’t
damaged, and that
the medicine isn’t frozen. The medicine should be colorless to slightly yellow—not cloudy, and there
should be no
particles.
02:24-02:28
[The checklist animates off screen as Alan wholesomely introduces us to the 4 steps for how to use
Zepbound.]
CAPTION: 4 steps / These 4 steps are not the complete instructions for using Zepbound.
Before
starting Zepbound, your healthcare provider should show you how to use the Zepbound pen. Please read the
full
Instructions for Use included with your pen.
ALAN: So far, so good? I’ve got four steps for you.
02:28-02:47
[Step 1 graphic animates on screen. The graphic highlights the stomach, thighs, and back of the upper
arms on a
silhouette. Alan delivers the first step.]
CAPTION: 1 CHOOSE YOUR INJECTION SITE / Please read the full Instructions for Use
included with your
Zepbound pen.
ALAN: First, choose your injection site. If you like, your doctor can help you with your choice.
You can
inject in your stomach or your thighs yourself, or the back of your upper arms with someone’s help.
It’s okay to
use the same area every week, but avoid injecting in the exact same spot. Today, I’ll go with my
stomach.
02:47-02:55
[Close up of Alan holding his Zepbound pen just below chest height. The Step 2 graphic animates on
screen. The
graphic displays the Zepbound pen in the locked position and the gray base cap being removed.]
CAPTION: 2 PULL OFF THE CAP / Please read the full Instructions for Use included with
your Zepbound
pen.
ALAN: And we’re already at Step 2. Make sure the pen is locked. Leave it locked until you place
it on
your skin to
inject.
02:55-03:03
[Alan turns away to throw the gray base cap into his household trash. He turns back to resume his
position by the
Step 2 graphic.]
CAPTION: 2 PULL OFF THE CAP / Please read the full Instructions for Use included with
your Zepbound
pen.
ALAN: Pull the gray base cap straight off and throw it away in your household trash. Don’t touch
the needle
or put the gray base cap back on.
03:03-03:10
[Alan lifts his shirt to expose his stomach. The Step 3 graphic animates on screen. The graphic displays
how to
place the Zepbound pen against one’s stomach and how to unlock it. Alan places his Zepbound pen on his
stomach and
turns the lock ring.
CAPTION: 3. PLACE AND UNLOCK / Please read the full Instructions for Use included with
your Zepbound
pen.
ALAN: Step 3. Place the clear base flat against your skin and unlock the pen by turning the lock
ring.
03:10-03:30
[Close up of Alan holding Zepbound pen against his stomach. Step 4 graphic animates on screen. The
graphic displays
how to press the purple button when the pen is unlocked. Alan presses the purple button of his Zepbound
pen.]
CAPTION: 4 PRESS AND HOLD UP TO 10 SECONDS / Please read the full Instructions for Use
included with
your Zepbound pen
ALAN: And we’re at Step 4. Press and hold the purple button for up to 10 seconds. You’ll hear
the first
click when it starts. Keep holding until you hear the second click, which means you’re done. Even if
you don’t
feel a poke, if you hear two clicks and see the gray plunger, the injection is complete.
03:30-03:34
[Alan is confidently standing behind his kitchen counter with his used Zepbound pen. An empty detergent
bottle that
has been labeled “SHARPS” and an FDA-cleared sharps container rest on the countertop in front of him.]
CAPTION: That’s it / Safely dispose of the used pen immediately after use. Do not throw
away pens in
the household trash. Please read the full Instructions for Use included with your Zepbound pen.
ALAN: And that’s it! The steps are the same for any dose.
03:34-03:39
[Alan securely disposes of his used Zepbound pen with the FDA-approved sharps container.]
ALAN: Afterward, safely dispose of the used pen in an FDA-cleared sharps container.
03:39-03:59
[Alan turns his attention to the empty detergent bottle that has been labeled “SHARPS.”]
ALAN: If you don’t have one, you can use a heavy-duty plastic household container, like an empty
detergent
bottle, that’s upright and stable. Make sure it can be closed with a tight-fitting, puncture-resistant
lid, is
leak-resistant, and is properly labeled as hazardous waste. And keep your Zepbound pen and all
medicines out of
the reach of children.
03:59-04:09
[Swipe to reveal Alan back in his home office. He is standing enthusiastically in front of his desk with
an assured
smile.]
ALAN: Once you get the hang of weekly injections, they’ll become a part of your routine. If you
need
more support,
just talk to your doctor or explore Zepbound.com.
04:09-04:13
[Swipe to white as the Zepbound logo animates in.]
CAPTION: once weekly Zepbound® (tirzepatide) injection 0.5 mL 2.5 mg | 5 mg | 7.5 mg |
10 mg | 12.5
mg | 15 mg
04:13-11:32
[The Zepbound logo fades out before Indications and Safety Summary with Warnings fades in and begins to
scroll.]
CAPTION: once weekly Zepbound® (tirzepatide) injection 0.5 mL 2.5 mg | 5
mg | 7.5 mg
| 10 mg | 12.5 mg | 15 mg / INDICATIONS AND SAFETY SUMMARY WITH WARNINGS
NARRATOR: INDICATIONS AND SAFETY SUMMARY WITH WARNINGS. Zepbound® is an injectable prescription
medicine that may
help adults with:
• obesity, or some adults with overweight who also have weight-related medical problems to lose excess
body weight
and keep the weight off.
• moderate-to-severe obstructive sleep apnea (OSA) and obesity to improve their OSA.
It should be used with a reduced-calorie diet and increased physical activity.
Zepbound contains tirzepatide and should not be used with other tirzepatide-containing products or any GLP-1 receptor agonist medicines. It is not known if Zepbound is safe and effective for use in children.
Warnings. Zepbound may cause tumors in the thyroid, including thyroid cancer. Watch for possible symptoms, such as a lump or swelling in the neck, hoarseness, trouble swallowing, or shortness of breath. If you have any of these symptoms, tell your healthcare provider.
Do not use Zepbound if you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC). Do not use Zepbound if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Do not use Zepbound if you have had a serious allergic reaction to tirzepatide or any of the ingredients in Zepbound.
Zepbound may cause serious side effects, including:
Severe stomach problems. Stomach problems, sometimes severe, have been reported in people who use Zepbound. Tell your healthcare provider if you have stomach problems that are severe or will not go away.
Kidney problems (kidney failure). Diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration), which may cause kidney problems. It is important for you to drink fluids to help reduce your chance of dehydration.
Gallbladder problems. Gallbladder problems have happened in some people who use Zepbound. Tell your healthcare provider right away if you get symptoms of gallbladder problems, which may include pain in your upper stomach (abdomen), fever, yellowing of skin or eyes (jaundice), or clay-colored stools.
Inflammation of the pancreas (pancreatitis). Stop using Zepbound and call your healthcare provider right away if you have severe pain in your stomach area (abdomen) that will not go away, with or without vomiting. You may feel the pain from your abdomen to your back.
Serious allergic reactions. Stop using Zepbound and get medical help right away if you have any symptoms of a serious allergic reaction, including swelling of your face, lips, tongue or throat, problems breathing or swallowing, severe rash or itching, fainting or feeling dizzy, or very rapid heartbeat.
Low blood sugar (hypoglycemia). Your risk for getting low blood sugar may be higher if you use Zepbound with medicines that can cause low blood sugar, such as a sulfonylurea or insulin. Signs and symptoms of low blood sugar may include dizziness or light-headedness, sweating, confusion or drowsiness, headache, blurred vision, slurred speech, shakiness, fast heartbeat, anxiety, irritability, mood changes, hunger, weakness or feeling jittery.
Changes in vision in patients with type 2 diabetes. Tell your healthcare provider if you have changes in vision during treatment with Zepbound.
Depression or thoughts of suicide. You should pay attention to changes in your mood, behaviors, feelings or thoughts. Call your healthcare provider right away if you have any mental changes that are new, worse, or worry you.
Food or liquid getting into the lungs during surgery or other procedures that use anesthesia or deep sleepiness (deep sedation). Zepbound may increase the chance of food getting into your lungs during surgery or other procedures. Tell all your healthcare providers that you are taking Zepbound before you are scheduled to have surgery or other procedures.
Common side effects. The most common side effects of Zepbound include nausea, diarrhea, vomiting, constipation, stomach (abdominal) pain, indigestion, injection site reactions, feeling tired, allergic reactions, belching, hair loss, and heartburn. These are not all the possible side effects of Zepbound. Talk to your healthcare provider about any side effect that bothers you or doesn’t go away.
Tell your doctor if you have any side effects. You can report side effects at 1-800-FDA-1088 or www.fda.gov/medwatch.
Before using Zepbound. Your healthcare provider should show you how to use Zepbound before you use it for the first time. Tell your healthcare provider if you are taking medicines to treat diabetes including an insulin or sulfonylurea which could increase your risk of low blood sugar. Talk to your healthcare provider about low blood sugar levels and how to manage them. If you take birth control pills by mouth, talk to your healthcare provider before you use Zepbound. Birth control pills may not work as well while using Zepbound. Your healthcare provider may recommend another type of birth control for 4 weeks after you start Zepbound and for 4 weeks after each increase in your dose of Zepbound.
Review these questions with your healthcare provider. Do you have other medical conditions, including problems with your pancreas or kidneys, or severe problems with your stomach, such as slowed emptying of your stomach (gastroparesis) or problems digesting food? Do you take diabetes medicines, such as insulin or sulfonylureas? Do you have a history of diabetic retinopathy? Are you scheduled to have surgery or other procedures that use anesthesia or deep sleepiness (deep sedation)? Do you take any other prescription medicines or over-the-counter drugs, vitamins, or herbal supplements? Are you pregnant, plan to become pregnant, breastfeeding, or plan to breastfeed? Zepbound may harm your unborn baby. Tell your healthcare provider if you become pregnant while using Zepbound. It is not known if Zepbound passes into your breast milk. You should talk with your healthcare provider about the best way to feed your baby while using Zepbound.
Pregnancy Exposure Registry: There will be a pregnancy exposure registry for women who have taken Zepbound during pregnancy. The purpose of this registry is to collect information about the health of you and your baby. Talk to your healthcare provider about how you can take part in this registry, or you may contact Lilly at 1-800-LillyRx (1-800-545-5979).
How to take. Read the Instructions for Use that come with Zepbound. Use Zepbound exactly as your healthcare provider says. Use Zepbound with a reduced-calorie diet and increased physical activity. Zepbound is injected under the skin (subcutaneously) of your stomach (abdomen), thigh, or upper arm. Use Zepbound 1 time each week, at any time of the day. Change (rotate) your injection site with each weekly injection. Do not use the same site for each injection. If you take too much Zepbound, call your healthcare provider, seek medical advice promptly, or contact a Poison Center expert right away at 1-800-222-1222.
Zepbound injection is approved as a 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, or 15 mg per 0.5 mL in single-dose pen or single-dose vial.
Learn more. Zepbound is a prescription medicine. For more information, call 1-800-LillyRx (1-800-545-5979) or go to www.zepbound.lilly.com.
This summary provides basic information about Zepbound but does not include all information known about this medicine. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your healthcare provider. Be sure to talk to your healthcare provider about Zepbound and how to take it. Your healthcare provider is the best person to help you decide if Zepbound is right for you.
ZP CON BS 20DEC2024
Zepbound® and its delivery device base are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.
11:32-11:35
[Dissolve to red screen as the Lilly: A Medicine Company logo fades in.]
CAPTION: Lilly
A MEDICINE COMPANY
PP-ZP-US-1049 01/2025 ©Lilly USA, LLC 2025. All rights reserved.
Zepbound® and its delivery device base are registered trademarks owned or licensed by Eli
Lilly and
Company, its
subsidiaries, or affiliates.
This injection guide can help too*
After you inspect your pen, follow these 4 steps to use Zepbound:
- Choose your injection site.
- Pull off the cap.
- Place and unlock.
- Press and hold up to 10 seconds.
Even if you don’t feel a poke, if you hear 2 clicks, the injection is complete! You will know you are done when the gray plunger is visible.
*These 4 steps are not the complete instructions for using Zepbound. Before starting Zepbound, your healthcare provider should show you how to use the Zepbound pen. Always inspect your pen prior to injection and read the full Instructions for Use included with your Zepbound pen or scroll up to watch the How to Use Zepbound video.
Check the authenticity of your medicine
Click the button below to check the authenticity of your medicine and see what genuine Zepbound looks like.
Check authenticityPRO TIP: Set a reminder on your phone so you don’t miss your weekly dose.
How to store Zepbound
- Store the pen in its original carton to protect it from light.
- Keep the pen in the refrigerator (at 36°F to 46°F).
- You may also store Zepbound at room temperature (up to 86°F) for up to 21 days. Do not return the pen to the refrigerator after removing it.
- If the pen hasn’t been used within 21 days after removing from the refrigerator, discard the pen.
- Don’t freeze the pen. If it has been frozen, throw it away and use a new pen instead.
- The pen has glass parts. Handle it carefully. If you drop it on a hard surface, discard it and use a new pen.
- Keep your Zepbound pen and all medicines out of the reach of children.
Disposing after use
It’s important to dispose of used Zepbound pens safely:
- Place your used pen in an FDA-cleared sharps disposal container after use. Don’t throw pens in the household trash.
- If you don’t have an FDA-cleared sharps container, there are other options. You can use a heavy-duty plastic household container, such as an empty laundry detergent bottle. Make sure it has a tight-fitting, puncture-resistant lid. It must also be stable, leak-resistant, and stand upright. Don’t forget to add a label that says “Sharps” or “Biohazard” to make it clear that it’s hazardous waste.
- Either way, keep the container out of the reach of children. Don’t recycle a sharps container. Check and follow your community’s guidelines for disposing of a sharps container.
Safe sharps containers:
FDA-cleared sharps container
Detergent bottles†
†Make sure these bottles are cleaned, emptied, and labeled before use.
Find the dose that's right for you
With multiple options, you and your doctor can work together to find the once-weekly dose of Zepbound that fits your body's changing needs.
Zepbound dosing is increased gradually over time
- The starting dose is 2.5 mg.‡
- After 4 weeks, your doctor will increase the dose to 5 mg.
- After at least another 4 weeks, your dose will increase by 2.5 mg increments until you find the dose that is right for you.
- The recommended maintenance dosage for OSA is 10 mg or 15 mg once weekly.§
‡2.5 mg is not intended for maintenance use.
§The maximum dosage is 15 mg under the skin (subcutaneously)
once weekly.
Keep up with your plan
You’ll work with your doctor to follow this step-by-step dosing process.

The starting dose is 2.5 mg once weekly. After 4 weeks, the dose will be increased to 5 mg. Your dose will be increased in 2.5 mg increments after at least 4 weeks on the current dose. The recommended maintenance dosage for OSA is 10 mg or 15 mg once weekly. The maximum dosage is 15 mg once weekly.
What if I miss a dose or want to change my schedule?
If you miss a dose of Zepbound, take it as soon as possible—within 4 days (96 hours) of your scheduled dosing. If more than 4 days have passed, skip the missed dose. Take your next dose on your regularly scheduled day. Do not take 2 doses of Zepbound within 3 days (72 hours) of each other.
If you want to change the day of the week you take Zepbound, make sure there are at least 3 days (72 hours) between doses.
Managing possible side effects
If you experience any side effects that are bothersome or persistent, talk to your doctor.
The most common side effects reported by people taking Zepbound were:
- Nausea
- Diarrhea
- Vomiting
- Constipation
- Stomach (abdominal) pain
- Indigestion
- Injection site reactions
- Fatigue
- Allergic reactions
- Belching
- Hair loss
- Heartburn
Side effects over time
In studies, most nausea, diarrhea, and vomiting occurred when people increased their dose—but the effects generally decreased over time.
In studies, gastrointestinal (GI) side effects were more common in people taking Zepbound than people taking placebo, and people taking Zepbound were more likely to stop treatment because of these side effects.
Select Safety Information
Zepbound can cause serious side effects, including:
Severe stomach problems. Stomach problems, sometimes severe, have been reported in people who use Zepbound. Tell your healthcare provider if you have stomach problems that are severe or will not go away.
Kidney problems (kidney failure). Diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration), which may cause kidney problems. It is important for you to drink fluids to help reduce your chance of dehydration.
Tips that may help with nausea
If you experience nausea, talk to your doctor. In the meantime, it may help to:
Eat smaller meals—try splitting 3 daily meals into 4 or more smaller ones
Stop eating when you feel full
Avoid fatty foods like butter or cheese
Try eating bland foods like toast, crackers, or rice