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Tips, tools, and all things Zepbound

Support is here

Tips, tools, and all things Zepbound

Resources to guide you on your Zepbound journey—from start to finish

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Zepbound tips

Timely tips, facts, and inspiration

Get emails or texts about all things Zepbound to help you take on your obstructive sleep apnea (OSA) with greater confidence and support.

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Doctor discussion guide

A guide to help get the conversation started

With a little prep, you can make the most of your time with your doctor. That’s the idea behind our Doctor Discussion Guide. Click the button below, and take a few minutes to consider your responses to this short list of questions.

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The Lilly Health™ app

The Lilly Health app* is a no-cost companion to support you on your journey with Zepbound.
The Lilly Health app offers personalized information, education, and insights to help you feel supported throughout your treatment journey, including:

  • Access to savings card information
  • Dose tracking and progress visualization
  • Ability to sync smart devices and apps for your convenience

*Lilly Health is not intended to provide treatment decisions or replace the care and advice of a licensed healthcare provider (HCP). All medical analysis and treatment plans should be performed by a licensed HCP.

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The 2.5 mg dose is for treatment initiation and is not intended to be a maintenance dose.

Prep for Zepbound

Learn how to use the Zepbound pen

Want to learn about injecting, storing, and disposing of Zepbound? Take a look at our quick video or read step-by-step instructions. You got this!

How to use Zepbound

Please also read the full Instructions for Use that come with your Zepbound pen.

To learn how to store and dispose of your Zepbound pen, click here .

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Finding out your insurance coverage doesn’t have to be complicated

Quickly check your coverage for Zepbound, discover which savings options may be available to you, and understand what your estimated cost could be.

Discover your options

Please have your insurance prescription card ready. The information from your prescription card is needed to use the tool.

This evaluation is based on the details you provide and is not a guarantee of coverage or available savings options. Please contact your insurance provider directly to confirm the accuracy of all coverage details obtained through this tool.

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Digital starter kit

Get resources for your Zepbound journey directly to your mobile device

Text the letters "ZO" to 85099 to access your kit and learn about starting on Zepbound.

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Getting the care you need can be quick and accessible

Explore speed, convenience, and access to focused care with independent telehealth or in-person providers through LillyDirect.

In-person care Telehealth

LillyDirect® is a registered trademark owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates. PP-LX-US-0052 03/2024 ©Lilly USA, LLC 2024. All rights reserved.

Advocacy & support

For additional support, information, and resources—including tools to advocate for improved access to care—visit the websites of these leading OSA and sleep advocacy organizations.

Logo of Project Sleep

The mission of Project Sleep is to educate the public about sleep health, sleep equity, and sleep disorders. Project Sleep's Sleep Apnea Squad program explores different aspects of living with sleep apnea through live educational broadcasts, podcasts, PDF toolkits, and social media shareables. It provides much-needed resources to help patients and families navigate the journey from diagnosis to treatment. To learn more, visit project-sleep.com/sleep-apnea-squad

Logo of Obesity Action Coalition (OAC)

The Obesity Action Coalition (OAC) is dedicated to uplifting and empowering individuals living with obesity through education, advocacy, and support. The organization aims to foster a society where:

  • Everyone is treated with respect, free from discrimination or bias, regardless of their size or weight.
  • Individuals with obesity have the right to access safe and effective treatment options.
  • Everyone understands that when it comes to health, "Your Weight Matters."
Additionally, the OAC offers a variety of free resources to help you learn more about the connection between obesity and obstructive sleep apnea. These include:
Logo of Alliance of Sleep Apnea Partners (ASAP)

Alliance of Sleep Apnea Partners (ASAP) is dedicated to educating patients and providers on sleep apnea and advocating on their behalf to ensure they have access to therapies that work for them. As a patient-led group, patient-centered care comes first to us. Our mission is to promote and advocate for equitable diagnosis and treatment of sleep to ensure optimal health of those who suffer from sleep apnea. For more information, please visit apneapartners.org where you can find educational resources and other relevant information. For resources and toolkits specific to women, visit apneapartners.org/free-resources .

Logo of the American Academy of Sleep Medicine (AASM)

Across the country, there are 2,300 sleep centers that are accredited by the American Academy of Sleep Medicine, ensuring that people who have obstructive sleep apnea and other sleep disorders receive the highest quality of care. To learn more, visit sleepeducation.org/sleep-center .

SAFETY SUMMARY WITH WARNINGS

Warning:

Warnings - Zepbound may cause tumors in the thyroid, including thyroid cancer. Watch for possible symptoms, such as a lump or swelling in the neck, hoarseness, trouble swallowing, or shortness of breath. If you have any of these symptoms, tell your healthcare provider.

  • Do not use Zepbound if you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC).
  • Do not use Zepbound if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
  • Do not use Zepbound if you have had a serious allergic reaction to tirzepatide or any of the ingredients in Zepbound.

Zepbound may cause serious side effects, including:

Severe stomach problems. Stomach problems, sometimes severe, have been reported in people who use Zepbound. Tell your healthcare provider if you have stomach problems that are severe or will not go away.

Kidney problems (kidney failure). Diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration), which may cause kidney problems. It is important for you to drink fluids to help reduce your chance of dehydration.

Gallbladder problems. Gallbladder problems have happened in some people who use Zepbound. Tell your healthcare provider right away if you get symptoms of gallbladder problems, which may include pain in your upper stomach (abdomen), fever, yellowing of skin or eyes (jaundice), or clay-colored stools.

Inflammation of the pancreas (pancreatitis). Stop using Zepbound and call your healthcare provider right away if you have severe pain in your stomach area (abdomen) that will not go away, with or without vomiting. You may feel the pain from your abdomen to your back.

Serious allergic reactions. Stop using Zepbound and get medical help right away if you have any symptoms of a serious allergic reaction, including swelling of your face, lips, tongue or throat, problems breathing or swallowing, severe rash or itching, fainting or feeling dizzy, or very rapid heartbeat.

Low blood sugar (hypoglycemia). Your risk for getting low blood sugar may be higher if you use Zepbound with medicines that can cause low blood sugar, such as a sulfonylurea or insulin. Signs and symptoms of low blood sugar may include dizziness or light-headedness, sweating, confusion or drowsiness, headache, blurred vision, slurred speech, shakiness, fast heartbeat, anxiety, irritability, mood changes, hunger, weakness or feeling jittery.

Changes in vision in patients with type 2 diabetes. Tell your healthcare provider if you have changes in vision during treatment with Zepbound.

Depression or thoughts of suicide. You should pay attention to changes in your mood, behaviors, feelings or thoughts. Call your healthcare provider right away if you have any mental changes that are new, worse, or worry you.

Food or liquid getting into the lungs during surgery or other procedures that use anesthesia or deep sleepiness (deep sedation). Zepbound may increase the chance of food getting into your lungs during surgery or other procedures. Tell all your healthcare providers that you are taking Zepbound before you are scheduled to have surgery or other procedures.

Common side effects

The most common side effects of Zepbound include nausea, diarrhea, vomiting, constipation, stomach (abdominal) pain, indigestion, injection site reactions, feeling tired, allergic reactions, belching, hair loss, and heartburn. These are not all the possible side effects of Zepbound. Talk to your healthcare provider about any side effect that bothers you or doesn’t go away.

Tell your doctor if you have any side effects. You can report side effects at 1-800-FDA-1088 or www.fda.gov/medwatch.

Before using Zepbound

  • Your healthcare provider should show you how to use Zepbound before you use it for the first time.
  • Tell your healthcare provider if you are taking medicines to treat diabetes including an insulin or sulfonylurea which could increase your risk of low blood sugar. Talk to your healthcare provider about low blood sugar levels and how to manage them.
  • If you take birth control pills by mouth, talk to your healthcare provider before you use Zepbound. Birth control pills may not work as well while using Zepbound. Your healthcare provider may recommend another type of birth control for 4 weeks after you start Zepbound and for 4 weeks after each increase in your dose of Zepbound.

Review these questions with your healthcare provider:

❑ Do you have other medical conditions, including problems with your pancreas or kidneys, or severe problems with your stomach, such as slowed emptying of your stomach (gastroparesis) or problems digesting food?

❑ Do you take diabetes medicines, such as insulin or sulfonylureas?

❑ Do you have a history of diabetic retinopathy?

❑ Are you scheduled to have surgery or other procedures that use anesthesia or deep sleepiness (deep sedation)?

❑ Do you take any other prescription medicines or over-the-counter drugs, vitamins, or herbal supplements?

❑ Are you pregnant, plan to become pregnant, breastfeeding, or plan to breastfeed? Zepbound may harm your unborn baby. Tell your healthcare provider if you become pregnant while using Zepbound. It is not known if Zepbound passes into your breast milk. You should talk with your healthcare provider about the best way to feed your baby while using Zepbound.

  • Pregnancy Exposure Registry: There will be a pregnancy exposure registry for women who have taken Zepbound during pregnancy. The purpose of this registry is to collect information about the health of you and your baby. Talk to your healthcare provider about how you can take part in this registry, or you may contact Lilly at 1-800-LillyRx (1-800-545-5979).

How to take

  • Read the Instructions for Use that come with Zepbound.
  • Use Zepbound exactly as your healthcare provider says.
  • Use Zepbound with a reduced-calorie diet and increased physical activity.
  • Zepbound is injected under the skin (subcutaneously) of your stomach (abdomen), thigh, or upper arm.
  • Use Zepbound 1 time each week, at any time of the day.
  • Change (rotate) your injection site with each weekly injection. Do not use the same site for each injection.
  • If you take too much Zepbound, call your healthcare provider, seek medical advice promptly, or contact a Poison Center expert right away at 1-800-222-1222.

Zepbound injection is approved as a 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, or 15 mg per 0.5 mL in single-dose pen or single-dose vial.

Learn more

Zepbound is a prescription medicine. For more information, call 1-800-LillyRx (1-800-545-5979).

This summary provides basic information about Zepbound but does not include all information known about this medicine. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your healthcare provider. Be sure to talk to your healthcare provider about Zepbound and how to take it. Your healthcare provider is the best person to help you decide if Zepbound is right for you.

ZP CON BS 20DEC2024

Zepbound® and its delivery device base are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.

INDICATIONS

Zepbound® (ZEHP-bownd) is an injectable prescription medicine that may help adults with:

  • obesity, or some adults with overweight who also have weight-related medical problems to lose excess body weight and keep the weight off.
  • moderate-to-severe obstructive sleep apnea (OSA) and obesity to improve their OSA.

It should be used with a reduced-calorie diet and increased physical activity.

Zepbound contains tirzepatide and should not be used with other tirzepatide-containing products or any GLP-1 receptor agonist medicines. It is not known if Zepbound is safe and effective for use in children.